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Molecular Approaches to Reproductive and Newborn Medicine


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Biology in SocietyGenomicsGenetics

Edited by Diana W. Bianchi, Tufts University School of Medicine; Errol Norwitz, Tufts University School of Medicine

Molecular Approaches to Reproductive and Newborn Medicine

Download Free Excerpts from Molecular Approaches to Reproductive and Newborn Medicine:

Preface

Index


© 2015 • 416 pages, illustrated (51 color, 12 B&W), index
Hardcover • £84 (click here to price in US Dollars)
ISBN  978-1-621820-89-5

  •     Description    
  •     Contents    

Description

The development of an infant, from conception to the postnatal period, involves the dynamic coordination of numerous biological factors in the mother, father, and fetus. The use of rapid and sensitive methods to probe these factors has made a remarkable impact on reproductive and neonatal medicine.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our current understanding of the molecular mechanisms involved in conception, pregnancy, placental development, labor, and birth, and how molecular techniques are being applied to reproductive and newborn health. The contributors discuss the gene expression profiles and epigenetic characteristics of sperm, the ovary, the endometrium, and the placenta, as well as the molecules involved in feto-maternal communication, including various endocrine, vascular, and immune factors. They also consider how we can harness this knowledge to improve fertility, conception rates, and embryo implantation success, and reduce pregnancy complications such as recurrent loss, preterm birth, and preeclampsia, thus leading to healthy, full-term pregnancies.

The authors also review innovative technologies to screen for and diagnose genetic disorders in fetuses and neonates and the social and ethical dilemmas these pose. The volume is therefore an indispensable reference for all scientists and physicians interested in deepening our understanding of human reproductive biology and translating that knowledge to improve the care of pregnant women and their newborns.

Contents

Preface
MOLECULAR ASPECTS OF REPRODUCTIVE DEVELOPMENT AND GAMETOGENESIS
MicroRNA in Ovarian Biology and Disease
Lynda K. McGinnis, Lacey J. Luense, and Lane K. Christenson
Confrontation, Consolidation, and Recognition: The Oocyte’s Perspective on the Incoming Sperm
David Miller
Intergenerational Transfer of Epigenetic Information in Sperm
Oliver J. Rando
The Role of HOX Genes in Female Reproductive Tract Development, Adult Function, and Fertility
Hongling Du and Hugh S. Taylor
MOLECULAR ASPECTS OF FERTILIZATION AND IMPLANTATION
Human Endometrial Transcriptomics: Implications for Embryonic Implantation
Eva Gómez, Maria Ruíz-Alonso, Jose Miravet, and Carlos Simón
A Molecular Perspective on Procedures and Outcomes with Assisted Reproductive Technologies
Monica A. Mainigi, Carmen Sapienza, Samantha Butts, and Christos Coutifaris
MOLECULAR ASPECTS OF PLACENTAL DEVELOPMENT
Molecular Cross-Talk at the Feto-Maternal Interface
Gendie E. Lash
Placental Extracellular Vesicles and Feto-Maternal Communication
Mancy Tong and Lawrence (Larry) W. Chamley
The Function of TrophomiRs and Other MicroRNAs in the Human Placenta
Yoel Sadovsky, Jean-Francois Mouillet, Yingshi Ouyang, Avraham Bayer, and Carolyn B. Coyne
The Human Placental Methylome
Wendy P. Robinson and E. Magda Price
MOLECULAR ASPECTS OF NORMAL PREGNANCY AND DELIVERY
The Perinatal Microbiome and Pregnancy: Moving Beyond the Vaginal Microbiome
Amanda L. Prince, Derrick M. Chu, Maxim D. Seferovic, Kathleen M. Antony, Jun Ma,
and Kjersti M. Aagaard
Molecular Regulation of Parturition: A Myometrial Perspective
Nora E. Renthal, Koriand’r C. Williams, Alina P. Montalbano, Chien-Cheng Chen, Lu Gao,
and Carole R. Mendelson
Molecular Regulation of Parturition: The Role of the Decidual Clock
Errol R. Norwitz, Elizabeth A. Bonney, Victoria V. Snegovskikh, Michelle A. Williams, Mark Phillippe,
Joong Shin Park, and Vikki M. Abrahams
MOLECULAR ASPECTS OF ABNORMAL PREGNANCY
Genetic Considerations in Recurrent Pregnancy Loss
Kassie J. Hyde and Danny J. Schust
Genomics of Preterm Birth
Kayleigh A. Swaggart, Mihaela Pavlicev, and Louis J. Muglia
Molecular Mechanisms of Preeclampsia
Tammy Hod, Ana Sofia Cerdeira, and S. Ananth Karumanchi
Effects of Maternal Obesity on Fetal Programming: Molecular Approaches
Caterina Neri and Andrea G. Edlow
PRENATAL MOLECULAR SCREENING AND DIAGNOSIS
Noninvasive Prenatal Screening for Genetic Diseases Using Massively Parallel Sequencing of Maternal Plasma DNA
Lyn S. Chitty and Y.M. Dennis Lo
Noninvasive Antenatal Determination of Fetal Blood Group Using Next-Generation Sequencing
Klaus Rieneck, Frederik Banch Clausen, and Morten Hanefeld Dziegiel
Genome-Wide Sequencing for Prenatal Detection of Fetal Single-Gene Disorders
Ignatia B. Van den Veyver and Christine M. Eng
The Amniotic Fluid Transcriptome as a Guide to Understanding Fetal Disease
Lillian M. Zwemer and Diana W. Bianchi
MOLECULAR APPROACHES TO DIAGNOSIS OF DISEASE IN THE NEONATE
Potential Uses and Inherent Challenges of Using Genome-Scale Sequencing to Augment Current Newborn Screening
Jonathan S. Berg and Cynthia M. Powell
Whole-Exome Sequencing and Whole-Genome Sequencing in Critically III Neonates Suspected to Have Single-Gene Disorders
Laurie D. Smith, Laurel K. Willig, and Stephen F. Kingsmore
The Neonatal Salivary Transcriptome
Jill L. Maron
Index