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The p53 Protein: From Cell Regulation to Cancer


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Guillermina Lozano, The University of Texas M.D. Anderson Cancer Center; Arnold J. Levine, Institute for Advanced Study

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Preface
Index


© 2016 • 504 pages, illustrated (69 color, 19 B&W), index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621821-33-5
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  •     Description    
  •     Contents    

Description

Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a “guardian of the genome,” protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in—and sometimes even promotes—human cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations.

Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.

Contents

Preface
I. THE STRUCTURE AND FUNCTIONS OF THE p53 PROTEIN
The Paradox of p53: What, How, and Why?
Yael Aylon and Moshe Oren
Structural Evolution and Dynamics of the p53 Proteins
Giovanni Chillemi, Sebastian Kehrloesser, Francesca Bernassola, Alessandro Desideri,
Volker Dötsch, Arnold J. Levine, and Gerry Melino
p53 Isoforms: Key Regulators of the Cell Fate Decision
Sebastien M. Joruiz and Jean-Christophe Bourdon
The Transactivation Domains of the p53 Protein
Nitin Raj and Laura D. Attardi
Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53
Neil T. Pfister and Carol Prives
Tumor-Suppressor Functions of the TP53 Pathway
Brandon J. Aubrey, Andreas Strasser, and Gemma L. Kelly
II. THE REGULATION OF CELLULAR FUNCTIONS BY THE p53 PROTEIN
p53 in the DNA-Damage-Repair Process
Ashley B. Williams and Björn Schumacher
Genome Stability Requires p53
Christine M. Eischen
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Jiandong Chen
Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres
Caitlin M. Roake and Steven E. Artandi
The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence
Crystal A. Tonnessen-Murray, Guillermina Lozano, and James G. Jackson
Autophagy and p53
Eileen White
The Evolution of the Ribosomal Protein–MDM2–p53 Pathway
Chad Deisenroth, Derek A. Franklin, and Yangping Zhang
Regulation of Cellular Metabolism and Hypoxia by p53
Timothy J. Humpton and Karen H. Vousden
The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation
Arnold J. Levine, Anna M. Puzio-Kuter, Chang S. Chan, and Pierre Hainaut
p53 and the Carcinogenicity of Chronic Inflammation
Andrei V Gudkov and Elena A. Komarova
III. p53 MUTATIONS IN HUMAN CANCERS
Somatic TP53 Mutations in the Era of Genome Sequencing
Pierre Hainaut and Gerd P. Pfeifer
The Inherited p53 Mutation in the Brazilian Population
Maria Isabel Achatz and Gerard P. Zambetti
Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation
Yoav Shetzer, Alina Molchadsky, and Varda Rotter
Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End
Amanda R. Wasylishen and Guillermina Lozano
Inherited TP53 Mutations and the Li–Fraumeni Syndrome
Tanya Guha and David Malkin
IV. THE p53 PATHWAY IN HUMAN CANCERS—CLINICAL MANIFESTATIONS
The Role of MDM2 Amplification and Overexpression in Tumorigenesis
Jonathan D. Oliner, Anne Y. Saiki, and Sean Caenepeel
MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond
Jean-Christophe Marine and Aart G. Jochemsen
Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges
Shaomeng Wang, Yujun Zhao, Angelo Aguilar, Denzil Bernard, and Chao-Yie Yang
TP53 Mutations in Breast and Ovarian Cancer
Laxmi Silwal-Pandit, Anita Langerød, and Anne-lise Børresen-Dale
p53 as an Effector or Inhibitor of Therapy Response
Julien Ablain, Brigitte Poirot, Cécile Esnault, Jacqueline Lehmann-Che, and Hugues de Thé
p53 and Medulloblastoma
Vijay Ramaswamy, Carolina Nör, and Michael D. Taylor
TP53 Mutations in Hypodiploid Acute Lymphoblastic Leukemia
Evan Q. Comeaux and Charles G. Mullighan
Clinical Outcomes of TP53 Mutations in Cancers
Ana I. Robles, Jin Jen, and Curtis C. Harris
Genetic Modifiers of the p53 Pathway
Subhasree Basu and Maureen E. Murphy
Exploiting the p53 Pathway for Therapy
Chit Fang Cheok and David Philip Lane
Index