Today, most scientists regard the term mutation as a description of a change in an individual gene, and more precisely as some minute alteration of the DNA of that gene, especially a nucleotide substitution. But the idea of mutation has changed considerably from the pre-Mendelian concepts of Darwins generation, who viewed fluctuating variations as the raw material on which evolution acted, to todays up-to-the-minute genomic context of mutation. Mutation: The History of an Idea from Darwin to Genomics explores six generations of mutation research, providing the backgroundthe people and the ideasfor this biological journey.
After exploring Darwins and Francis Galtons concepts of mutation, Carlson shows how the 1900 rediscovery of Gregor Mendels experiments let to a discontinuous model of evolution by mutation and how cytological investigations led to the chromosome theory of heredity of classical genetics in which there was random mutation in genes. Carlson details how Mendelian and biometric approaches to heredity and evolution were closely tied and how induction of mutations by radiation and chemical mutagens led to biochemical investigations of gene action, shifting attention to the chemistry of the gene. The interpretation of the gene as DNA and the deciphering of the genetic code then gave rise to molecular interpretations of mutation, views that also impacted evolutionary biology, population genetics, commercial development of plants and animals, and human genetics.
This book shows how generational definitions or assessments of mutation have responded to the technologies added to science and the experiments that abounded with the inquiries of each successive generation. These observations are combined with an exploration of how the nonscientific public has shifted its understanding and concern about mutations over the past 150 or more years. Carlsons historical approach in this bookexamining the evolution of a conceptreveals the way science works, incrementally by small steps of additions and replacements rather than by dramatic, and rare, paradigm shifts.
...the idea of mutation has meant different things over time, changing greatly how Darwin perceived it to how it is used in the context of the genome. It is the evolution of the concept of mutation that drives Elof Axel Carlsons new book...Beginning with Darwin and pre-Mendelian ideas of what mutation was, continuing through to the ideas of mutagenesis,...and mutation in relation to evolution, Carlson admirably straddles the very fine line between losing the reader in overly detailed explanations or by being so vague as to say nothing at all. The book is a quick read. It doesnt seek so much to re-educate readers on what mutation is, as it does construct a timeline of how scientists have perceived it through the past couple of centuries....Carlsons book presents a history of the concept of mutation, but also a history of how science itself has changed because of that words evolution....In seeking to lend a sense of history to a word that is used often in todays science, Carlson succeeds.
Genome Web Daily News
Carlson trained as a Drosophila geneticist with Hermann Muller surely the person who has done more than any other in advancing our understanding of mutation. But he is also a historian, as witnessed by his previous books...Altogether Carlsons account of the story of mutation is well told...Genetics has been fortunate in having such a wide-range and thoughtful person as Carlson to examine the topic of mutation from a broad perspective, and I greatly hope that this book will not only be enjoyed by geneticists of all kinds, but that it will lead them to Carlson’s other equally enjoyable historical books on genetics.
This book provides an excellent view of mutation theories from a historical perspective, and it gives the reader an appreciation for those involved in the process and the difficulty some theories faced in gaining acceptance by the scientific community....It is an easy read for scientists and nonscientists alike, and a valuable resource for genetics or history of science courses.
Because Carlson has been directly involved in some of the research, there are details and insights one is unlikely to find in any other public reference source....Mutation: The History of an Idea from Darwin to Genomics tells this story in an engaging narrative....
Biologists conceptions of hereditary variation and mutation have undergone considerable shifts since the days of Darwin. In Mutation:The History of an Idea from Darwin to Genomics, Carlson traces those changes in the meaning of the term from genetics at the turn of the 20th century to the emergence of genomics, identifying the researchers involved and how ideas evolved....Carlson includes commentary on human genetics, concern for genetic effects [of] radiation with the development of atomic weapons, and the use of radiation in medicine and industry. He argues that the deployment of new techniques has resulted in the changed meaning of mutation, and in this regard, all readers will agree.
The Quarterly Review of Biology