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Synthetic Biology: Tools for Engineering Biological Systems


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyGenomicsMolecular BiologyGenetics

Edited by Daniel G. Gibson, J. Craig Venter Institute; Clyde A. Hutchison III, J. Craig Venter Institute; Hamilton O. Smith, J. Craig Venter Institute; J. Craig Venter, J. Craig Venter Institute

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Preface
Minimal CellsóReal and Imagined
Index


Due June 2017 • 280 pages, illustrated (55 color, 9 B&W), index
Hardcover • £84 58.80 (click here to price in US Dollars)
ISBN  978-1-621821-18-2
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Description

Synthetic biology involves the rational design and construction of biological components and systems—from genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR–Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered.

The authors also explore ways to produce new organisms and products that have particular attributes—for example, microbial “molecular factories,” synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

Contents

Preface
DESIGN, SYNTHESIS, AND MANIPULATION OF GENOMES
Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology
Randall A. Hughes and Andrew D. Ellington
Minimal Cells–Real and Imagined
John I. Glass, Chuck Merryman, Kim S. Wise, Clyde A. Hutchison III, and Hamilton O. Smith
Genome-Editing Technologies: Principles and Applications
Thomas Gaj, Shannon J. Sirk, Sai-lan Shui, and Jia Liu
MODIFYING THE CENTRAL DOGMA
Alternative Watson–Crick Synthetic Genetic Systems
Steven A. Benner, Nilesh B. Karalkar, Shuichi Hoshika, Roberto Laos, Ryan W. Shaw, Mariko Matsuura, Diego Fajardo, and Patricia Moussatche
At the Interface of Chemical and Biological Synthesis: An Expanded Genetic Code
Han Xiao and Peter G. Schultz
EXPERIMENTAL AND COMPUTATIONAL APPROACHES TO THE DESIGN AND IMPROVEMENT OF BIOLOGICAL PROCESSES
Cell-Free Synthetic Biology: Engineering Beyond the Cell
Jessica G. Perez, Jessica C. Stark, and Michael C. Jewett
Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities
Jessica K. Polka, Stephanie G. Hays, and Pamela A. Silver
Design Automation in Synthetic Biology
Evan Appleton, Curtis Madsen, Nicholas Roehner, and Douglas Densmore
APPLICATIONS TO SMALL MOLECULE PRODUCTION
The Need for Integrated Approaches in Metabolic Engineering
Anna Lechner, Elizabeth Brunk, and Jay D. Keasling
Synthetic Biology of Natural Products
Rainer Breitling and Eriko Takano
APPLICATIONS TO HIGHER ORGANISMS
Engineering Gene Circuits for Mammalian Cell–Based Applications
Simon Ausländer and Martin Fussenegger
Synthetic Biology in Cell and Organ Transplantation
Sean Stevens
Synthetic Morphogenesis
Brian P. Teague, Patrick Guye, and Ron Weiss
Synthetic Botany
Christian R. Boehm, Bernardo Pollak, Nuri Purswani, Nicola Patron, and Jim Haseloff
Phage Therapy in the Era of Synthetic Biology
E. Magda Barbu, Kyle C. Cady, and Bolyn Hubby
Index