Contents

Symposium Participants

Foreword

Psychiatric Neuroscience



Challenges and Opportunities in Psychiatric Neuroscience

Joshua A. Gordon, Julie A. Frost Bellgowan, Collene Lawhorn, and Rachel B. Scheinert



The Neurobiology of Confidence: From Beliefs to Neurons

Torben Ott, Paul Masset, and Adam Kepecs



Causal Inference on Pathophysiological Mediators in Psychiatry

Ho Namkung, Brian J. Lee, and Akira Sawa

Neurodevelopment and Synapses



Parvalbumin Interneuron Plasticity for Consolidation of Reinforced Learning

Matteo Tripodi, Komal Bhandari, Ananya Chowdhury, Arghya Mukherjee, and Pico Caroni



Adolescence and “Late Blooming” Synapses of the Prefrontal Cortex

Kristen Delevich, A. Wren Thomas, and Linda Wilbrecht



The Synaptomic Theory of Behavior and Brain Disease

Seth G.N. Grant



Sleep and Neuromodulation



Genetic Mechanisms Underlying Sleep

Hirofumi Toda, Mi Shi, Julie A. Williams, and Amita Sehgal



Brain Circuitry for Arousal from Apnea

Clifford B. Saper and Satvinder Kaur



Computational Underpinnings of Neuromodulation in Humans

P. Read Montague and Kenneth T. Kishida



Multiple Dopamine Systems: Weal and Woe of Dopamine

Mitsuko Watabe-Uchida and Naoshige Uchida



Social Behavior



Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress

Moriel Zelikowsky, Keke Ding, and David J. Anderson



The Hippocampus and Social Impairment in Psychiatric Disorders

Matthew Schafer and Daniela Schiller



Nucleus Accumbens Modulation in Reward and Aversion

Anna M. Klawonn and Robert C. Malenka



Neurological Health



Epigenetic Priming in Drug Addiction

Philipp Mews, Deena M. Walker, and Eric J. Nestler



Decoding Depression: Insights from Glial and Ketamine Regulation of Neuronal Burst Firing in Lateral Habenula

Yihui Cui, Yan Yang, Yiyan Dong, and Hailan Hu



Improving Mouse Models for Dementia. Are All the Effects in Tau Mouse Models Due to Overexpression?

Zelah Joel, Pablo Izquierdo, Dervis A. Salih, Jill C. Richardson, Damian M. Cummings, and Frances A. Edwards



Distinct Conformers of Assembled Tau in Alzheimer’s and Pick’s Diseases

Michel Goedert, Benjamin Falcon, Wenjuan Zhang, Bernardino Ghetti, and Sjors H.W. Scheres



Treatments



Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction

Graziella Madeo and Antonello Bonci



Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Cell (iPSC)-Based Model of Dravet Syndrome

Yishan Sun and Ricardo E. Dolmetsch



A Network Explanation of Alzheimer’s Regional Vulnerability

Scott A. Small and Larry W. Swanson



Current Status of Deep Brain Stimulation for Alzheimer’s Disease: From Chance Observation to Clinical Trials

Darrin J. Lee and Andres M. Lozano



Benefits of Enhancing Nicotinamide Adenine Dinucleotide Levels in Damaged or Diseased Nerve Cells

Andrew A. Pieper and Steven L. McKnight



Summary



Order and Disorder in Brains and Behavior

Adam Kepecs



Dorcas Cummings Lecture



P. Read Montague

Conversations at the Symposium



Edward Boyden



Yang Dan



Ricardo Dolmetsch



Paul Glimcher



Michel Goedert



Joshua A. Gordon



Adam Kepecs



Robert C. Malenka



Helen Mayberg



P. Read Montague



Michael Platt



Daniela Schiller



Scott Small



Beth Stevens



Li-Huei Tsai



Kay Tye



Mehmet Faith Yanik



Huda Zoghbi



Author Index

Subject Index