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Download a Free Excerpt from Next-Generation DNA Sequencing Informatics, Second Edition: Preface and Contents Chapter 13: RNA Sequencing with Next-Generation Sequencing Index
Download a Free Excerpt from Next-Generation DNA Sequencing Informatics, Second Edition:
Preface and Contents Chapter 13: RNA Sequencing with Next-Generation Sequencing Index
402 pages, illustrated (81 color, 20 B&W), index
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Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applications including variant (mutation) discovery, gene expression, transcription factor analysis, metagenomics, and epigenetics. Bioinformatics methods to support DNA sequencing have become and remain a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This new edition provides a thorough, plain-language introduction to the necessary informatics methods and tools for analyzing NGS data and provides detailed descriptions of algorithms, strengths and weaknesses of specific tools, pitfalls, and alternative methods. Four new chapters cover experimental design, sample preparation, and quality assessment of NGS data; public databases for DNA sequencing data; de novo transcript assembly; proteogenomics; and emerging sequencing technologies. The remaining chapters from the first edition have been updated with the latest information. This book also provides extensive reference to best-practice bioinformatics methods for NGS applications and tutorials for common workflows. This edition addresses the informatics needs of students, laboratory scientists, and computing specialists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.
“Next-Generation DNA Sequencing Informatics (2nd edition)...is a book to get you well and truly started in Bioinformatics....the chapters appear to flow well internally and cover the main aspects of the methods presented. Certainly the QC and RNA-seq chapters will point students or new bioinformaticians in the right direction....this book is likely to be a good one to have on your shelf.”
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