- Description
- Contents
- Reviews
Description
In this brief, readable, and revealing book, one of the pioneers of the now rapidly evolving field of DNA repair traces the history of the discovery of the more important mechanisms by which cells respond to DNA damage. Errol Friedberg has written an enjoyable and informative introduction to the study of DNA mutagenesis and re-pair that will interest students at an advanced undergraduate or graduate student level as well as investigators in fields as diverse as oncogenesis, cell cycle regulation, transcription and DNA replication.
Contents
CHAPTER 1: In the Beginning
CHAPTER 2: Let There Be Light: The Discovery of Enzymatic Photoreactivation
CHAPTER 3: The Emergence of Excision Repair
CHAPTER 4: New Mechanisms for Repairing DNA
CHAPTER 5: Mismatched Bases Are Repaired by Yet a Different Mode
CHAPTER 6: The Remarkable SOS Phenomenon
CHAPTER 7: Epilogue: Molecule of the Year 1994
Notes
Reviews
"Friedberg provides a real inspiration by recounting some of the rich experiences that the scientific life can offer. We are treated to descriptions of sudden flashes of insight over a dram of whisky at a conference in the Scottish highlands, pivotal blackboard discussions with students, and colleagues taking Sunday afternoon walks while planning experiments and searching for fossils
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For those currently investigating DNA repair, this fluent account is essential reading, and would also be a fine complement to courses on the history of molecular biology."
Nature