Click to Enlarge

Add To Cart

A Cure Within: Scientists Unleashing the Immune System to Kill Cancers


Subject Area(s):  Immunology and VaccinesDiseasesCancer Biology

By Neil Canavan

Due October 2017 • 230 pages (approx.), illustrated, index
Hardcover • $24 21.60 (click here to price in UK Pounds)
ISBN  978-1-621822-17-2
You save: 10%

  •     Description    
  •     Contents    

Description

The way we treat cancer is about to change forever. This revolution—and it is precisely that—was sparked not by the invention of a new drug, but by the evolution of an entirely new way of thinking about and managing cancer. Going forward, doctors will not use pharmaceuticals to attack tumors – not directly. Rather, the oncologist will treat the patient’s immune system with a drug, and then the patient will treat the tumor.

Based entirely on interviews with the investigators, this book is the story of the IO pioneers. It’s a story of failure, resurrection, and success. It’s a story about science, it’s a story about discovery, and intuition, and cunning. It’s a peek into the lives and thoughts of some of the most gifted medical scientists on the planet.

This is not a textbook. This is a life book. This technology will save/is saving lives, and the book will celebrate the living, breathing, thinking, charming, arrogant, funny, obstinate, drinking-too-much, not-drinking-enough, amazing human beings who are making IO happen.

Contents

(preliminary)
Acknowledgments
Introduction
SECTION I: CTLA-4
1. James Allison
2. Jedd Wolchok
3. Axel Hoos
SECTION II: PD-1
4. Tasuku Honjo
5. Gordon Freeman
6. Suzanne L. Topalian
7. Robert Schreiber, Cancer Immuno-Editing
SECTION III: Vaccines
8. Drew Pardoll
9. Elizabeth Jaffee
10. Ralph Steinman, Dendritic Cells (DCs)
11. Tak Mak, T-Cell Receptor (TCR)
12. Philip Greenberg, Adoptive Cell Therapy (ACT)
13. Steven Rosenberg, Interleukin-2 (IL-2)
SECTION IV: Chimeric Antigen Receptor – T Cells (CAR-Ts)
14. Zelig Eshhar
15. Patrick Hwu
16. Carl June
17. Michel Sadelain
18. Patrick Baeuerle, Bispecific Antibodies
19. Robert Coffin, Oncolytics
SECTION V: T Regulatory Cells (Tregs)
20. Shimon Sakaguchi
21. Jeff Bluestone
22. David Munn, Indoleamine 2,3-Dioxygenase (IDO)
23. Dmitry Gabrilovich, Myeloid Derived Suppressor Cells (MDSCs)
24. Tom Gajewski, Stimulator of Interferon Genes (STING)
25. Laurence Zitvogel, Microbiome
Epilogue
Glossary
Index