` Translation Mechanisms and Control

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Translation Mechanisms and Control

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Molecular Biology

Edited by Michael B. Mathews, Rutgers - New Jersey Medical School Cancer Center; Nahum Sonenberg, McGill University; John W.B. Hershey, University of California, Davis

Due September 2018 • 300 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621821-86-1
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  •     Description    
  •     Contents    


Translation converts the genetic code in messenger RNA molecules copied from DNA into a specific sequence of amino acids in a protein. It occurs on ribosomes in the cell cytoplasm and is one of the most fundamental biological processes. This volume examines the detailed molecular machinery responsible for translation and the regulatory mechanisms that make the process a critical control point for the cell.


1. History of Protein Synthesis and Translational Control
Nahum Sonenberg, John W.B. Hershey, and Michael B. Mathews
2. Principles of Translational Control
Nahum Sonenberg, John W.B. Hershey, and Michael B. Mathews
3. Protein Synthesis Initiation in Eukaryotic Cells
William C. Merrick and Graham D. Pavitt
4. Translation Elongation and Recoding in Eukaryotes
Thomas E. Dever, Jonathan D. Dinman, and Rachel Green
5. Translation Termination and Ribosome Recycling in Eukaryotes
Christopher U.T. Hellen
6. Translation in Prokaryotes
Marina V. Rodnina
7. New Insights into Ribosome Structure and Function
Amy Jobe, Zheng Liu, Cristina Gutierrez-Vargas, and Joachim Frank
8. Ribosome Profiling
Jonathan Weissman and Nicholas Inglolia
9. Kinetics
Chris Fraser
10. Single Molecule
Jody Puglisi
11. Fluorescence Imaging Methods to Investigate Translation in Single Cells
Jeetayu Biswas, Yang Liu, Robert H. Singer, and Bin Wu
12. mRNA Modification and Function/Regulation
Dan Dominissini
13. 1nc, Circular, and Other RNAs
Nicholas Rajewsky and Marina Chekulaeva
14. mRNPs/RNA Binding Proteins
Markus Landthaler
15. Alternative Initiation in Eukaryotes
Sunnie Thompson
16. RAN Translation in Neurological Diseases
Tao Zu, Amrutha Pattamatta, and Laura P.W. Ranum
17. The Interplay Between the RNA Decay and Translation Machinery in Eukaryotes
Adam M. Heck and Jeffrey Wilusz
18. NMD Begins Where Translation Ends
Evangelos D. Karousis and Oliver Mühlemann
19. NMD Update
Ron Breaker
20. microRNAs
Marc Fabian
21. Stress Granules and Processing Bodies in Translational Control
Pavel Ivanov, Nancy Kedersha, and Paul Anderson
22. Role of elF2α Kinases in Translational Control and Adaptation to Cellular Stress
Ronald C. Wek
23. Signaling Pathways and the Regulation of mRNA Translation
Philippe P. Roux and Ivan Topisirovic
24. Cancer
Nahum Sonenberg
25. Development
Ruth Lehmann
26. Synaptic Plasticity and Memory
Mauro Costa-Mattioli
27. Translational Control in Virus-Infected Cells
Noam Stern-Ginossar, Sunnie R. Thompson, and Ian Mohr
28. Translating Therapeutics
Jennifer Chu and Jerry Pelletier