Next-Generation Sequencing in Medicine

Click to Enlarge				Next-Generation Sequencing in Medicine Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Human Biology and Disease; Molecular Biology Edited by W. Richard McCombie, Cold Spring Harbor Laboratory; Elaine R. Mardis, Washington University School of Medicine; James A. Knowles, University of Southern California, Keck School of Medicine; John D. McPherson, Ontario Institute for Cancer Research *Download a Free Excerpt from Next-Generation Sequencing in Medicine:* Preface Next-Generation Sequencing Technologies Index

				© 2019 • 192 pages, illustrated (27 color), index Hardcover • ~~$135~~ 94.50 ISBN 978-1-621821-13-7 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description Next-generation sequencing technologies have the capacity to generate large numbers of DNA sequence reads at relatively high speed and low cost. These technologies have revolutionized biomedical research and are increasingly employed in clinical settings, where they can be used to detect inherited disorders, predict disease risk, and personalize therapies. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines next-generation sequencing technologies and their use, particularly in translational research. The contributors discuss the various sequencing platforms, their capabilities, and their applications in both research and clinical practice. The roles of next-generation sequencing in diagnosing autism and intellectual disabilities, monitoring cancers during disease progression, and determining the most appropriate drug treatments for patients are also covered. In addition, the authors consider the practical challenges (e.g., data storage) and ethical implications of using next-generation sequencing technologies. This volume is therefore an essential read for all scientists and physicians interested in these technologies and how they are impacting biomedicine. Contents Preface Next-Generation Sequencing Technologies W. Richard McCombie, John D. McPherson, and Elaine R. Mardis Next-Generation Sequencing Strategies Shawn E. Levy and Braden E. Boone Single-Cell Applications of Next-Generation Sequencing Naishitha Anaparthy, Yu-Jui Ho, Luciano Martelotto, Molly Hammell, and James Hicks Sequencing in High Definition Drives a Changing Worldview of the Epigenome Emily Hodges Clinical Versus Research Sequencing Yuriy Shevchenko and Sherri Bale High-Throughput Sequencing and Assessing Disease Risk Shannon M. Rego and Michael P. Snyder The Use of Next-Generation Sequencing for Research and Diagnostics for Intellectual Disability Ricardo Harripaul, Abdul Noor, Muhammad Ayub, and John B. Vincent Next-Generation Sequencing in Autism Spectrum Disorder Stephan J. Sanders The Role of Next-Generation Sequencing in Pharmacogenetics and Pharmacogenomics Ute I. Schwarz, Markus Gulilat, and Richard B. Kim Whole-Genome Sequencing in Cancer Eric Y. Zhao, Martin Jones, and Steven J.M. Jones Characterizing the Cancer Genome in Blood Sarah-Jane Dawson The Impact of Next-Generation Sequencing on Cancer Genomics: From Discovery to Clinic Elaine R. Mardis Next-Generation Sequencing and the Return of Results Bartha Maria Knoppers, Minh Thu Nguyen, Karine Sénécal, Anne Marie Tassé, and Ma’n H. Zawati Future Promises and Concerns of Ubiquitous Next-Generation Sequencing W. Richard McCombie and John D. McPherson Index

Next-Generation Sequencing in Medicine

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