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Calcium Signaling, Second Edition


Subject Area(s):  Cell BiologyBiochemistry

Edited by Geert Bultynck, KU Leuven; Martin D. Bootman, The Open University; Michael J. Berridge, The Babraham Institute; Grace E. Stutzmann, Rosalind Franklin University / The Chicago Medical School

Due September 2019 • 325 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621822-92-9
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  •     Description    
  •     Contents    

Description

Calcium signals—rapid changes in calcium ion concentration—are carefully orchestrated by a suite of proteins that transport and bind to calcium ions inside cells. These signals influence virtually all aspects of animal development and physiology, from fertilization and cell differentiation to muscle contraction and nerve impulses. Aberrant calcium signaling is associated with various pathologies (e.g., cancer and neurodegeneration) as well as aging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on all facets of calcium signaling. The contributors discuss the components and activities of the various calcium-sequestering organelles inside cells, the dynamic interactions that lead to spatiotemporally distinct signals in different circumstances, and the downstream effector mechanisms that translate the signals into biological outcomes. Recent advances in the field (e.g., structural insights into the functions of certain calcium channels) are emphasized throughout.

The authors also discuss normal and perturbed calcium signaling during fertilization, development, physiology, regeneration, aging, and disease. This volume is therefore an indispensable reference for biochemists, cell and developmental biologists, and physiologists seeking a comprehensive treatment of calcium signaling.

Contents

Preface
CALCIUM ENTRY
Transient Receptor Potential (TRP) Channels and Calcium Signaling
Laura Vangeel and Thomas Voets
SOC
Richard Lewis
ER-PM Junction: A hub for Agonist-Regulation of Ca2+ Entry
Hwei Ling Ong and Indu Suresh Ambudkar
CALCIUM RELEASE
Structure and Function of IP3 Receptors
David L. Prole and Colin W. Taylor
NAADP Receptors
Antony Galione
Calcium Leak Channels
Martin Bootman and Geert Bultynck
Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels
Pradeep Barak and Anant B. Parekh
CALCIUM STORES AND CALCIUM TRANSPORT MACHINES
Primary Active Ca2+ Transport Systems in Health and Disease
Jialin Chen, Aljona Sitsel, Veronick Benoy, M. Rosario Sepúlveda, and Peter Vangheluwe
The Roles of Mitochondria in Calcium Signaling: Molecules Involved in Mitochondrial Calcium Uptake
Rosario Rizzuto
Cytoplasmic and Mitochondrial Calcium Signaling: A Two-Way Relationship
Benjamin Wacquier, Laurent Combettes, and Geneviève Dupont
Lysosomal Calcium Signaling
Emry Lloyd-Evans
Cytosolic Ca2+ Buffers are Inherently Ca2+ Signal Modulators
Beat Schwaller
Organellar Calcium Handling in the Cellular Reticular Network
Wen-An Wang, Luis B. Agellon, and Marek Michalak
DOWNSTREAM EFFECTORS OF CALCIUM
Interplay Between Calcium and cAMP Signaling
Aldebaran Hofer
Structural Insights Into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII)
Moitrayee Bhattacharyya, Deepti Karandur, and John Kuriyan
Calcium Sensors in Neuronal Function and Dysfunction
Robert D. Burgoyne, Nordine Helassa, Hannah V. McCue, and Lee P. Haynes
Identifying New Substrates and Functions for an Old Enzyme: Calcineurin
Jagoree Roy and Martha S. Cyert
PHYSIOLOGICAL PROCESSES REGULATED BY CALCIUM
Calcium and Fertilization
Rafael Fissore
Role of Two-Pore Channels in Embryonic Development and Cellular Differentiation
Sarah E. Webb, Jeffrey J. Kelu, and Andrew L. Miller
Functional Consequences of Calcium-Dependent Synapse-to-Nucleus Communication: Focus on Transcription-Dependent Metabolic Plasticity
Anna M. Hagenston, Hilmar Bading, and Carlos Bas-Orth
Calcium Signaling in Cardiomyocyte Function
Guillaume Gilbert, Kateryna Demydenko, Eef Dries, Rosa DoƱate Puertas, Karin Sipido, and H. Llewelyn Roderick
Astroglial Calcium Signaling in Ageing and Alzheimer’s Disease
Alexei Verkhratsky
Ca2+ Signaling and Regeneration
Jonathan S. Marchant
CALCIUM AND DISEASE
Creating a New Cancer Therapeutic Agent by Targeting the Interaction Between Bcl-2 and IP3 Receptors
Clark W. Distelhorst and Martin D. Bootman
The Calcium Signaling Toolkit in Cancer: Remodeling and Targeting
Sarah J. Roberts-Thomson, Silke B. Chalmers, and Gregory R. Monteith
Calcium and Neuropathology
Grace E. Stutzman
Calcium Signaling and Tissue Calcification
Diane Proudfoot
Ca2+ Signaling in Exocrine Cells
Malini Ahuja, Woo Young Chung, Wei-Yin Lin, Beth A. McNally, and Shmuel Muallem
Index