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T-Cell Memory

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyImmunology and VaccinesCytology

Edited by David Masopust, University of Minnesota School of Medicine; Rafi Ahmed, Emory University School of Medicine

Due August 2021 • 400 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621821-55-7
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  •     Description    
  •     Contents    


T cells are a major component of adaptive immunity, differentiating to form distinct subsets that directly attack pathogens, promote the activity of antibody-producing cells, and regulate other components of the immune system. This volume discusses the roles of these different subsets and how they are generated.


Topic I. Memory T-cell heterogeneity and classification: How should we name our T-cells?
Memory T-Cell Heterogeneity and Terminology
Yuki Muroyama and E. John Wherry
The Naming of Memory T-Cell Subsets
Stephen C. Jameson
How to Reliably Define Human CD8+ T-Cell Subsets: Markers Playing Tricks
Michiel C. van Aalderen, Rene A.W. van Lier, and Pleun Hombrink
Formation of Tissue-Resident CD8+ T-Cell Memory
Feline E. Dijkgraaf, Lianne Kok, and Ton N.M. Schumacher
CD8+ T Cell Memory: The Why, The When, and The How
Stephen J. Turner Taylah J. Bennett, and Nicole L. La Gruta
Topic II. Memory T-cell differentiation models
A Regenerative Perspective on Successful and Failed T-Cell Immunity
Steven L. Reiner
Motility Matters: How CD8+ T-Cell Trafficking Influences Effector and Memory Cell Differentiation
Susan M. Kaech, Bryan McDonald, and Yagmur Farsakoglu
Transcriptional Control of Cell Fate Determination in Antigen-Experienced CD8 T Cells
Shanel Tsuda and Matthew E. Pipkin
Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory
Tasha A. Morrison, William H. Hudson, Danielle A. Chisolm, Yuka Kanno, Han-Yu Shih, Rafi Ahmed, Jorge Henao-Mejia, Markus Hafner, and John J. O’Shea
Temporal and Epigenetic Control of Plasticity and Fate Decision During CD8+ T-Cell Memory Differentiation
Luigia Pace
Metabolic Control of Memory T-Cell Generation and Stemness
Jana L. Raynor, Nicole M. Chapman, and Hongbo Chi
A Single-Cell Perspective on Memory T-Cell Differentiation
Lorenz Kretschmer, Dirk H. Busch, and Veit R. Buchholz
Topic III. Tissue memory
T-Cell Memory: Tissue Memory
Simone L. Park and Laura K. Mackay
Divergence of Tissue-Memory T Cells: Distribution and Function-Based Classification
Shiki Takamura
Influenza-Specific Lung-Resident Memory CD8+ T Cells
Stephanie van de Wall, Vladimer P. Badovinac, and John T. Harty
Long-Lived Skin Resident Memory T-Cells Contribute to Concomitant Immunity in Cutaneous Leishmaniasis
Phillip Scott
Area Under Immunosurveillance: Dedicated Roles of Memory CD8 T-Cell Subsets
Loreto Parga-Vidal and Klaas P.J.M. van Gisbergen
Topic IV. Memory T-cell homeostasis and durability
CD4+ Memory T-Cell Formation During Acute Infections
Peter Krueger, Kevin Osum, and Marc K. Jenkins
Defining the Molecular Hallmarks of T-Cell Memory
Caitlin Zebley, Rama Akondy, Benjamin Youngblood, and Haydn Kissick
Homeostasis of Naïve and Memory T Lymphocytes
Takeshi Kawabe, Jaeu Yi, and Jonathan Sprent
Homeostasis and Durability of T-Cell Memory—The Resting and the Restless T-Cell Memory
Andreas Radbruch, Mairi Anne McGrath, Francesco Siracusa, Ute Hoffmann, Özen Sercan-Alp, Andreas Hutloff, Koji Tokoyoda, Hyun-Dong Chang, and Jun Dong
Durable CD4 T-Cell Memory Generation Depends on Persistence of High Levels of Infection at an Effector Checkpoint that Determines Multiple Fates
Susan L. Swain, Michael C. Jones, Priyadharshini Devarajan, Jingya Xia, Richard W. Dutton, Tara M. Strutt, and K. Kai McKinstry