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Glia, Second Edition


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  NeurobiologyCytology

Edited by Beth Stevens, Boston Children's Hospital; Kelly R. Monk, OHSU -Vollum Institute; Marc R. Freeman, OHSU -Vollum Institute

Download a Free Excerpt from Glia, Second Edition:

Preface
Glia Development and Function in the Nematode Caenorhabditis elegans
Index


© 2025 • 686 pages, illustrated (94 color), index
Hardcover • $79
ISBN  978-1-621824-64-0

  •     Description    
  •     Contents    

Description

Glia represent the majority of cells in the nervous system. Originally believed to be passive cells that support the neurons that transmit electrical signals, glial cells are now known to play a far more active part in neural development and function than previously appreciated.

Written and edited by experts in the field, this new collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of the major classes of glial cells—astrocytes, oligodendrocytes, Schwann cells, and microglia. The contributors review how technical advances and the use of worm, fly, and fish model systems are providing fascinating insights in their roles in normal physiology and disease. They discuss how glia control synapse formation and plasticity, regulate blood flow, and organize axonal domains. They describe how glia are formed and generated from precursor cells during development. Other chapters tackle the roles of glial cells in myelination, connections with the lymphatic system, and neuroimmune interactions.

The authors also discuss the functions of glia in tissue repair and regeneration, as well as disease processes such as glioma, demyelinating diseases, and neurodegenerative conditions. This volume is therefore a valuable reference for neuroscientists and biologists wishing to understand how these pathologies arise.

Contents

Preface
SECTION 1. NONMAMMALIAN MODELS FOR STUDYING GLIAL BIOLOGY
Glia Development and Function in the Nematode Caenorhabditis elegans
Aakanksha Singhvi, Shai Shaham, and Georgia Rapti
Glial Regulation of Circuit Wiring, Firing, and Expiring in the Drosophila Central Nervous System
Jaeda Coutinho-Budd, Marc R. Freeman, and Sarah Ackerman
Glia as Functional Barriers and Signaling Intermediaries
Vilaiwan M. Fernandes, Vanessa Auld, and Christian Klämbt
Glial Cell Development and Function in the Zebrafish Central Nervous System
Tim Czopka, Kelly Monk, and Francesca Peri
SECTION 2. ASTROCYTES
Generation of Mammalian Astrocyte Functional Heterogeneity
Theresa Bartels, David H. Rowitch, and Omer Ali Bayraktar
Astrocyte Regulation of Synapse Formation, Maturation, and Elimination
Won-Suk Chung, Katherine T. Baldwin, and Nicola J. Allen
Astrocyte Calcium Signaling
Misha B. Ahrens, Baljit S. Khakh, and Kira E. Poskanzer
Astrocyte Regulation of Cerebral Blood Flow in Health and Disease
Anusha Mishra, Grant R. Gordon, Brian A. MacVicar, and Eric A. Newman
The Astrocyte: Metabolic Hub of the Brain
L. Felipe Barros, Stefanie Schirmeier, and Bruno Weber
Reactive Astrocytes and Emerging Roles in Central Nervous System (CNS) Disorders
Shane A. Liddelow, Michelle L. Olsen, and Michael V. Sofroniew
SECTION 3. OLIGODENDROCYTES AND MYELINATION
Features, Fates, and Functions of Oligodendrocyte Precursor Cells
Robert A. Hill, Akiko Nishiyama, and Ethan G. Hughes
Regulators of Oligodendrocyte Differentiation
Ben Emery and Teresa L. Wood
Oligodendrocytes: Myelination, Plasticity, and Axonal Support
Mikael Simons, Erin M. Gibson, and Klaus-Armin Nave
SECTION 4. SCHWANN CELLS
Schwann Cell Development and Myelination
James Salzer, M. Laura Feltri, and Claire Jacob
The Nodes of Ranvier: Mechanisms of Assembly and Maintenance
Matthew N. Rasband and Elior Peles
Perisynaptic Schwann Cells: Guardians of Neuromuscular Junction Integrity and Function in Health and Disease
Thomas W. Gould, Chien-Ping Ko, Hugh Willison, and Richard Robitaille
Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and Pathologies
Ruth M. Stassart, Jose A. Gomez-Sanchez, and Alison C. Lloyd
SECTION 5. MICROGLIA
Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)
Amanda Sierra, Veronique E. Miron, Rosa C. Paolicelli, and Richard M. Ransohoff
Role of Microglia in Central Nervous System Development and Plasticity
Dorothy P. Schafer, Beth Stevens, Mariko L. Bennett, and Frederick C. Bennett
SECTION 6. NEUROIMMUNE INTERACTIONS AND GLIA AT THE BORDERS OF NEURAL TISSUES
The Blood–Brain Barrier: Composition, Properties, and Roles in Brain Health
Baptiste Lacoste, Alexandre Prat, Moises Freitas-Andrade, and Chenghua Gu
Satellite Glial Cells: No Longer the Most Overlooked Glia
Susan J. Birren, Lisa V. Goodrich, and Rosalind A. Segal
Enteric Glia
Meenakshi Rao and Brian D. Gulbransen
Glia at Transition Zones
Sarah Kucenas, Pernelle Pulh, Piotr Topilko, and Cody J. Smith
Cellular Contributions to Glymphatic and Lymphatic Waste Clearance in the Brain
Leon C.D. Smyth, Natalie Beschorner, Maiken Nedergaard, and Jonathan Kipnis
SECTION 7. DISEASE AND REPAIR
Remyelination in the Central Nervous System
Robin J.M. Franklin, Benedetta Bodini, and Steven A. Goldman
Glial Malignancies
Suzanne J. Baker, Hui Zong, and Michelle Monje
Glia in Neurodegenerative Disease
Gerard Crowley, David Attwell, Hemali Phatnani, Harald Sontheimer, and Soyon Hong
Multiple Sclerosis and Other Acquired Demyelinating Diseases of the Central Nervous System
Michael D. Kornberg and Peter A. Calabresi
Glial Origins of Inherited White Matter Disorder
Anjana Sevagamoorthy, Adeline Vanderver, Jamie L. Fraser, and Jennifer Orthmann-Murphy
Peripheral Nervous System (PNS) Myelin Diseases
Steven S. Scherer and John Svaren
Index