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Parkinson's Disease, Second Edition


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Neurobiology

Edited by Stanley Fahn, Vagelos College of Physicians and Surgeons, Columbia University; Serge Przedborksi, Vagelos College of Physicians and Surgeons, Columbia University

Due October 2025 • 400 pages (approx.), illustrated, index
Hardcover •
ISBN  978-1-621825-03-6

  •     Description    
  •     Contents    

Description

Parkinson’s Disease is a progressive neurodegenerative disorder whose underlying causes have proven difficult to establish. This second edition of the Cold Spring Harbor volume reviews recent progress in our understanding of the underlying biology, genetic and environmental contributions, and progress in development of new therapies for the condition.

Contents

Preliminary
Preface
Neuropathology of Parkinson’s Disease and Parkinsonism
Dennis W. Dickson
T Cell Dynamics and Implications in Parkinson's Disease Pathogenesis
Wassim Elyaman
Innate Immunity and Parkinson’s Disease
Davina D. Oludipe, Xiaoqing Du, Samia Akter, Chen Zhang, R. Lee Mosley, Howard E. Gendelman, and Susmita Sil
Exploring Parkinson’s Through the Lens of Genomics and Bioinformatics
Vilas Menon
Dopamine Cell-Based Replacement Therapies
Saeed Kayhanian and Roger A. Barker
Modelling Parkinson’s Disease in Primates
Erwan Bezard, Margaux Teil, Marie-Laure Arotcarena, Gregory Porras, Qin Li, and Benjamin Dehay
Lipid Alterations and Pathogenic Roles in Synucleinopathies
Estela Area-Gómez, Saranna Fanning, and Ulf Dettmer
Pathophysiology of Motor Control Abnormalities in Parkinson’s Disease
Thomas Wichmann
Functional Neuroanatomy of the Normal and Pathological Basal Ganglia
José L. Lanciego and José A. Obeso
The Gut-Brain Axis in Parkinson’s Disease
Virginia Gao, Carl V. Crawford, and Jacqueline Burré
Autophagy and Protein Quality Control in Parkinson’s Disease
Marta Martinez-Vicente and Miquel Vila
Leucine Rich Repeat Kinase 2: Pathways to Parkinson’s Disease
Suzanne R. Pfeffer and Dario R. Alessi
Clinical Management of Parkinson’s Disease: Features, Diagnosis, and Principles of Treatment
Bhavana Patel, Ashley Rawls, Tracy Tholanikunnel, Michael S. Okun
Progression in Parkinson’s Disease
Krithi Irmady and Serge Przedborski
Historical Perspectives of Parkinson’s Disease: Early Clinical Descriptions and Neurological Therapies
Christopher G. Goetz
Toxin-Induced Animal Models of Parkinson’s Disease
Kim Tieu, Said S. Salehe, and Harry J. Brown
Animal Models of Parkinson’s Disease: Vertebrate Genetics
Ted Dawson and Valina Dawson
Alpha-Synuclein in Parkinson’s Disease: 12 Years Later
Kostas Vekrellis, Evangelia Emmanouilidou, Maria Xilouri, and Leonidas Stefanis
Genetics of Parkinson’s Disease: From Causes to Treatment
Ana Westenberger, Norbert Brüggemann, and Christine Klein
Imaging of Disease-Related Networks in Parkinson’s Disease
Martin Niethammer, Yoshikazu Nakano, and David Eidelberg
Biomarkers
Julian Agin-Liebes and Lexie Lodge
The Mitochondrial Connection in Parkinson’s Disease
Eric Schon, Diana Matheoud, and Serge Przedborski
Index