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Type 1 Diabetes: Advances in Understanding and Treatment 100 Years After the Discovery of Insulin, Second Edition


Subject Area(s):  Human Biology and DiseaseBiochemistryBiophysics

Edited by Jeffrey A. Bluestone, Sonoma Biotherapeutics; Kevan C. Herold, Yale School of Medicine; Lori Sussel, University of Colorado Anschutz Medical Center

Due January 2025 • 350 pages (approx.), illustrated, index
Hardcover • $79
ISBN  978-1-621825-07-4

  •     Description    
  •     Contents    

Description

Type 1 diabetes is caused by destruction of pancreatic cells that produce insulin and affects millions of individuals worldwide. Celebrating the 100th year of the discovery of insulin, this book reviews advances, our understanding of the pathology of type 1 diabetes and its environmental and genetic triggers, the role of the immune system, and novel therapeutic approaches.

Contents

Preliminary
1. The Pathogenesis of Type 1 Diabetes
Kevan C. Herold and Jeffrey P. Krischer
2. Environmental Factors in Type 1 Diabetes
Heikki Hyöty, Jutta E. Laiho, and Suvi M. Virtanen
3. Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes
Gerald T. Nepom
4. Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes
Chester Chamberlain, Mike German, Lou Phillipson, and Mark S. Anderson
5. Advancing Animal Models of Human Type 1 Diabetes
David V. Serreze, Jennifer R. Dwyer, and Jeremy J. Racine
6. Cross-Talk Between β Cells and Immune Cells: What We Know, What We Think We Know, and What We Should Learn
Fatoumata Samassa, Capucine Holtzmann, and Roberto Mallone
7. Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes
Anil Bhushan and Peter J. Thompson
8. The Chicken or the Egg Dilemma: Understanding the Interplay between the Immune System and the β Cell in Type 1 Diabetes
Maria Skjøtt Hansen, Pravil Pokharel, Jon Piganelli, and Lori Sussel
9. The Human Pancreas in Type 1 Diabetes: Lessons Learned from the Network of Pancreatic Organ Donors with Diabetes
Irina Kusmartseva, Amanda Posgai, Mingder Yang, Richard Oram, Mark Atkinson, Alberto Pugliese, and Carmella Evans-Molina
10. The Role of B Lymphocytes in Type 1 Diabetes
Mia J. Smith, Joanne Boldison, and F. Susan Wong
11. Innate Immunity in Type 1 Diabetes
Léo Bertrand, Alexander V. Chervonsky, and Agnès Lehuen
12. T Cell Differentiation in Autoimmune Type 1 Diabetes
Andrea Schietinger, Ian McBain, Katrina M. Hawley, and Svetlana Miakicheva
13. Genetics and Epigenetics of Type 1 Diabetes Self-Reactive T Cells
Tae Gun Kang and Benjamin Youngblood
14. Epitope Hierarchy in Type 1 Diabetes Pathogenesis
Thomas Delong and Maki Nakayama
15. Integrating Omics into Functional Biomarkers of Type 1 Diabetes
S. Alice Long and Peter S. Linsley
16. Checkpoint Inhibitor-Induced Autoimmune Diabetes: An Autoinflammatory Disease
Zoe Quandt, Ana Perdigoto, Mark S. Anderson, and Kevan C. Herold
17. Rebalancing the Immune System to Treat Type 1 Diabetes
Yannick D. Muller, Patrick Ho, Jeffrey A. Bluestone, Qizhi Tang
18. Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes: Challenges, Choice and Timing of Immunomodulators
Danijela Tatovic and Colin Dayan
19. Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes
Mark Peakman and Pere Santamaria
20. The Teplizumab Saga: The Challenge of Not Getting Lost in Clinical Translation
Lucienne Chatenoud, Kevan C. Herold, Jean-François Bach, and Jeffrey A. Bluestone
21. Advances in Islet Transplantation and the Future of Stem Cell–Derived Islets to Treat Diabetes
Timothy J. Kieffer, Corinne A. Hoesli, and A.M. James Shapiro
Index