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RNA Control and Regulation

(Cold Spring Harbor Symposia on Quantitative Biology LXXXIV)

Subject Area(s):  BiotechnologyMolecular BiologyGeneticsBiochemistry

Edited by Terri Grodzicker, Cold Spring Harbor Laboratory; David Stewart, Cold Spring Harbor Laboratory; Bruce Stillman, Cold Spring Harbor Laboratory

Due August 2020 • Pages TBD, illustrated, index
Hardcover • $155
ISBN  978-1-621823-95-7

This title also available in: Paperback

  •     Description    
  •     Contents    

Description

Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA’s influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators in many fields. The topics covered at the meeting included: RNA-Based Structures; RNA Modifications; Nuclear Localization of RNA; Quality Control & Editing; RNA & Gene Regulation; Cotranscriptional Splicing; Intron/Exon Boundaries; Alternative Polyadenylation; Transposon Control; Small Noncoding RNAs; Long Noncoding RNAs; RNA & Development; Membrane-Less Organelles; Phase Separation; RNA-Based Diseases; and Novel RNA Functions. Numerous speakers participated in interviews during the course of the Symposium week and this volume includes transcripts of those discussions and the Dorcas Cummings lecture, for the general public, which was given by Dr. Jennifer Doudna.

Contents

Preliminary
INTRODUCTION
RNP Granules in Health and Disease
Roy Parker
3′UTRs Regulate Protein Functions by Providing a Nurturing Niche during Protein Synthesis
Christine Mayr
GLOBAL ANALYSES AND STRUCTURES
Zipcode Binding Protein 1 (ZBP1; IGF2BP1): A Model for Sequence Specific RNA Regulation
Jeetayu Biswas, Leti Nunez, Sulagna Das, Young J. Yoon, Carolina Eliscovich, and Robert H. Singer
Coordination of RNA Processing Events In Vivo
Karla M. Neugebauer
The Intrinsic Structure of poly(A) RNA Determines the Specificity of Deadenylation
Lori A. Passmore
Genome Regulation by Long Noncoding RNAs
Furqan M. Fazal, Howard Y. Chang
REGULATION OF RNA FUNCTIONS
The THO Complex as a Paradigm for the Prevention of co-Transcriptional R-Loops
Rosa Luna, Ana G. Rondón, Carmen Pérez-Calero, Irene Salas-Armenteros, and Andrés Aguilera
LSM2-8 and XRN-2 Contribute to the Silencing of H3K27me3-Marked Genes through Targeted RNA Decay
Susan M. Gasser
Telescripting⎯U1 snRNP Suppression of Premature Transcription Termination as a New Layer of Gene Regulation
Gideon Dreyfuss
Nonsense-mediated mRNA Decay in Health and Disease
Lynn E. Maquat
GENE REGULATION
Mechanistic Dissection of RNA Binding Proteins in Regulated Gene Expression at Chromatin Levels
Jia-Yu Chen, Do-Hwan Lim, and Xiang-Dong Fu
Linking RNA Processing and Function
Run-Wen Yao, Chu-Xiao Liu, and Ling-Ling Chen
Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination
Deirdre C. Tatomer and Jeremy E. Wilusz
RNA AND DISEASE
Functional and Mechanistic Interplay of Host and Viral Alternative Splicing Regulation during Influenza Infection
Matthew G. Thompson and Kristen W. Lynch
Cell-specific RNA CLIP
Robert B. Darnell
SMALL RNAs AND DEFENSE SYSTEMS
How Complementary Targets Expose the MicroRNA 3′ End for Tailing and Trimming during Target-Directed MicroRNA Degradation
Paulina Pawlica, Jessica Sheu-Gruttadauria, Ian J. MacRae, and Joan A. Steitz
Dicer's Helicase Domain: A Meeting Place for Regulatory Proteins
Sarah R. Hansen, Adedeji M. Aderounmu, Helen M. Donelick, and Brenda L. Bass
Molecular and Structural Basis of the Interaction of Gtsf1/arx with tRNA in the piRNA Pathway
Leemor Joshua-Tor
Mechanisms of RNA Channeling from DNA Transcription to Argonaute Loading in the siRNA-directed DNA Methylation
Craig S. Pikaard
DEVELOPMENTAL REGULATION
Transposable Elements in Early Mammalian Development-Do They Burst?
Maria-Elena Torres-Padilla
CONDENSATES AND PHASE SEPARATION
Regulation of Heterochromatin Condensates by RNA and DNA
G.J. Narlikar
Architectural RNAs for Membraneless Nuclear Body Formation
Tomohiro Yamazaki, Shinichi Nakagawa, and Tetsuro Hirose
RNA Organization within Phase Transitioned Germ Granules
Ruth Lehmann
CHROMATIN AND RNA
The Chromosomal Impact of small RNAs
Robert A. Martienssen
Molecular Mechanisms of poly(A) Tail Length Regulation
Elena Conti
Long Noncoding RNAs in Development and Regeneration of the Neural Lineage
Hadas Nezroni, Rotem Ben Tov Perry, and Igor Ulitsky
SUMMARY Gideon Dreyfuss
Index