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The Biology of Exercise

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and Disease

Edited by Juleen R. Zierath, Karolinska Institutet; Michael J. Joyner, Mayo Clinic; John A. Hawley, Australian Catholic University

Due August 2017 • 408 pages (approx.), illustrated, index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621821-65-6
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Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered.

The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health.


Physiological Redundancy and the Integrative Responses to Exercise
Michael J. Joyner and Jerome A. Dempsey
The Bioenergetics of Exercise
P. Darrell Neufer
Health Benefits of Exercise
Gregory N. Ruegsegger and Frank W. Booth
Theoretical and Biologic Evaluation of the Link Between Low Exercise Capacity and Disease Risk
Lauren Gerard Koch and Steven L. Britton
Exercise Metabolism: Fuels for the Fire
Mark Hargreaves and Lawrence L. Spriet
Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge and future challenges.
Christopher G.R. Perry and John A. Hawley
Rate Coding and the Control of Muscle Force
Roger M. Enoka and Jacques Duchateau
Molecular Basis for Exercise-Induced Fatigue; The Importance of Strictly Controlled Cellular Ca2+
Arthur J. Cheng, Nicolas Place, and HÃ¥kan Westerblad
Performance Fatigability: Mechanisms and Task Specificity
Sandra K. Hunter
Molecular Regulation of Exercise-Induced Muscle Fiber Hypertrophy
Marcas M. Bamman, Brandon M. Roberts, and Gregory R. Adams
Adaptations to Endurance and Strength Training
David C. Hughes, Stian Ellefsen, and Keith Baar
Autophagy-Dependent Beneficial Effects of Exercise
Jens Frey Halling and Henriette Pilegaard
Effects of Exercise and Aging on Skeletal Muscle
Giovanna Distefano and Bret H. Goodpaster
On the Run for Hippocampal Plasticity
C’iana Cooper, Hyo Youl Moon, and Henriette van Praag
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
Christoph Hoffmann and Cora Weigert
Muscle-Adipose Tissue Crosstalk
Kristin I. Stanford and Laurie J. Goodyear
Effects of Exercise on Vascular Function, Structure, and Health in Humans
Daniel J. Green and Kurt J. Smith
Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise
Adeel Safdar and Mark A. Tarnopolsky
Role of Nuclear Receptors in Exercise-Induced Muscle Adaptations
Barbara Kupr, Svenia Schnyder, and Christoph Handschin
Control of Muscle Metabolism by the Mediator Complex
Leonela Amoasil, Eric N. Olson, and Rhonda Bassel-Duby
The Role of MicroRNAs in the Cardiac Response to Exercise
Xiaojun Liu, Colin Platt, and Anthony Rosenzweig
Exercise and the Skeletal Muscle Epigenome
Sean L. McGee and Ken R. Walder
Omics and Exercise: Global Approaches for Mapping Exercise Biological Networks
Nolan J. Hoffman