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Malaria: Biology in the Era of Eradication

Subject Area(s):  Human Biology and Disease

Edited by Dyann Wirth, Harvard School of Public Health; Pedro Alonso, University of Barcelona

© 2017 • 312 pages, illustrated (33 color, 3 B&W), index
Hardcover • $68 47.60
ISBN  978-1-621821-22-9
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A renewed global effort in malaria control and elimination over the past decade has led to a substantial increase in basic research and significant advances in our understanding of the mechanisms underlying this complex disease. However, it is not always clear how such gains in knowledge will translate into improved strategies for the fight against malaria.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine explores recent developments in our understanding of malaria biology and their potential to influence malaria elimination/eradication strategies. The authors describe recent developments in their respective research areas and suggest both how these insights could guide intervention strategy and where critical knowledge gaps remain. Contributors discuss the unique features and challenges presented at key stages of the malaria life cycle and by different Plasmodium species, malaria transmission and its interruption, the challenge of drug resistance, the future of malaria vaccine strategies, epigenetic regulation of malaria-associated genes, and new approaches in malaria research, including genomics and modeling. They describe complex interactions of the malaria parasite with the human host, including disease pathogenesis, immune responses, and malaria in pregnancy. They also explore critical developments in vector biology, control, and insecticide resistance and in vector–parasite interactions, including the relationship between mosquito reproduction and parasite development.

The current state of each of these fields, their potential for impact on malaria elimination strategy and critical knowledge gaps, and next steps to achieve this are discussed. This volume is therefore a valuable reference for all scientists, clinicians, and public health professionals interested in understanding the state-of-the-art of malaria biology research and its critical role in our collective ambition to end this devastating disease.


Malaria Transmission and Prospects for Malaria Eradication: The Role of the Environment
Marcia C. Castro
Determinants of Malaria Transmission at the Population Level
Teun Bousema and Chris Drakeley
Biology of Malaria Transmission
Elamaran Meibalan and Matthias Marti
The Biology of Plasmodium vivax
John H. Adams and Ivo Mueller
Anopheline Reproductive Biology: Impacts on Vectorial Capacity and Potential Avenues for Malaria Control
Sara N. Mitchell and Flaminia Catteruccia
Modern Vector Control
Neil F. Lobo, Nicole L. Achee, John Greico, and Frank H. Collins
Current and Future Prospects for Preventing Malaria Transmission via the Use of Insecticides
Hilary Ranson
Plasmodium Sporozoite Biology
Friedrich Frischknecht and Kai Matuschewski
Malaria Parasite Liver Infection and Exoerythrocytic Biology
Ashley M. Vaughan and Stefan H.I. Kappe
Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes
Shailja Singh and Chetan E. Chitnis
Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination
Caeul Lim, Selasi Dankwa, Aditya S. Paul, and Manoj T. Duraisingh
Immune Responses in Malaria
Carole A. Long and Fidel Zavala
Malaria Pathogenesis
Danny A. Milner, Jr.
Malaria during Pregnancy
Michal Fried and Patrick E. Duffy
Malaria Genomics in the Era of Eradication
Daniel E. Neafsey and Sarah K. Volkman
Malaria Epigenetics
Alfred Cortés and Kirk W. Deitsch
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Didier Menard and Arjen Dondorp
Vaccines to Accelerate Malaria Elimination and Eventual Eradication
Julie Healer, Alan F. Cowman, David C. Kaslow, and Ashley J. Birkett
Malaria Modeling in the Era of Eradication
Thomas A. Smith, Nakul Chitnis, Melissa Penny, and Marcel Tanner

Latest advances in malaria research in free eBook by Cold Spring Harbor Laboratory Press

J.C. Flowers Foundation grant gives practitioners in malaria-endemic areas access to a critical resource

Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press (CSHLP) today announced a grant from the J.C. Flowers Foundation (JCFF) to support the free eBook distribution of the research monograph, Malaria: Biology in the Era of Eradication. JCFF funding enables this newly published title to reach scientists, clinicians and care-givers throughout malaria-endemic areas such as Africa, Southeast Asia, and South America.

"As malaria is a global health priority that continues to affect millions of people worldwide, there is an urgent need for readily accessible research on the disease, especially when working with 'last mile' communities where it is often logistically or financially difficult to apply current research,"says Chris Flowers, founder of JCFF. “We are pleased to join with Cold Spring Harbor's publishing initiatives to further the efforts to eliminate this disease."

Malaria: Biology in the Era of Eradication is a new, critically important collection of papers edited by Dyann Wirth, Harvard School of Public Health, and Pedro Alonso, Director of the WHO Global Malaria Programme in Geneva, Switzerland. With contributions from more than two dozen scientists worldwide, the book brings together in a single volume the latest advances and emerging strategies in the fight against malaria. The eBook is available at no charge for download and unrestricted sharing via the CSHLP website in an interactive PDF format, which includes links to cited research and additional online resources. “The JCFF's invaluable support is making this important collection available to researchers and clinicians who are most in need of it,"says Dr. John Inglis, Executive Director and Publisher of CSHL Press. “Cold Spring Harbor Laboratory is grateful to partners such as JCFF for their help in advancing both biological research and the sharing of new knowledge with scientific and medical communities worldwide."

To access the free eBook of Malaria: Biology in the Era of Eradication, or for more information on this title, please visit:

About J.C. Flowers Foundation - Partners for the Last Mile

The J.C. Flowers Foundation addresses critical health and social problems affecting vulnerable and hard to reach populations often overlooked by traditional donors. The Foundation works closely with other funding organizations, governments and local grassroots organizations in “last mile"communities to eliminate malaria in sub-Saharan Africa and support recent parolees in Harlem, New York with returning to their communities. Sponsorship for distribution of Malaria: Biology in the Era of Eradication is a part of the Isdell:Flowers Cross Border Malaria Initiative

The J.C. Flowers Foundation provides these last-mile communities with the financial, technical and operational support needed to achieve their own locally determined solutions. The Foundation brings to the table access to partnerships and advocacy at national and international levels.

About Cold Spring Harbor Laboratory Press

Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. Since 1933, it has furthered the advance and spread of scientific knowledge in all areas of genetics and molecular biology, including cancer biology, plant science, bioinformatics, and neurobiology. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. About Cold Spring Harbor Laboratory

Founded in 1890, Cold Spring Harbor Laboratory has shaped contemporary biomedical research and education with programs in cancer, neuroscience, plant biology and quantitative biology. Home to eight Nobel Prize winners, the private, not-for-profit Laboratory employs 1,100 people including 600 scientists, students and technicians. The Meetings & Courses Program hosts more than 12,000 scientists from around the world each year on its campuses in Long Island and in Suzhou, China. The Laboratory's education arm also includes an academic publishing house, a graduate school and programs for middle and high school students and teachers. For more information, visit


Robert Redmond
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