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Essentials of Glycobiology, Third Edition

Subject Area(s):  Cell BiologyMolecular BiologyBiochemistry

Edited by Ajit Varki, University of California, San Diego; Richard D. Cummings, Harvard Medical School, Boston, MA; Jeffrey D. Esko, University of California, San Diego; Pamela Stanley, Albert Einstein College of Medicine, New York; Gerald Hart, Johns Hopkins University, Baltimore, Maryland; Markus Aebi, ETH Zürich, Switzerland; Alan Darvill, University of Georgia, Athens; Taroh Kinoshita, Osaka University, Japan; Nicolle H. Packer, Macquarie University, Sydney, Australia; James H. Prestegard, University of Georgia, Athens; Ronald L. Schnaar, Johns Hopkins University, Baltimore, Maryland; Peter H. Seeberger, Max-Planck-Institute of Colloids and Interfaces, Potsdam-Golm, Germany

Due August 2017 • 823 pages, illustrated (223 color and 62 B&W), index
Hardcover • $165 132.00 (click here to price in UK Pounds)
ISBN  978-1-621821-32-8
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  •     Description    
  •     Contents    


Defined in the broadest sense, Glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in nature in all living life forms. Glycobiology is now one of the more rapidly growing fields in the natural sciences, with broad relevance to many areas of basic research, biomedicine, and biotechnology. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, roles of glycans in complex biological systems, and their analysis or manipulation by various techniques. The third edition of this primary textbook in the field continues in the prior tradition, seeking to provide basic overview of Glycobiology, directed towards the advanced undergraduate or the beginning graduate-level student of molecular and cellular biology and biomedicine. While efforts have been made to avoid a major increase in overall length of the text, substantial changes and improvements include the following:

  • Broader focus on all lineages of life forms in nature.
  • Wider range of topics, ranging from biology and medicine to chemistry and materials science.
  • Expanded international editorial board representing a wider range of expertise.
  • Wider range of contributing authors with expertise in specific areas.
  • Greatly expanded monosaccharide symbol nomenclature for the representation of glycans.
  • Greater attention to informatics, and integration with databases on other classes of molecules.

Advance Comments on the Third Edition of Essentials of Glycobiology

"The field of glycobiology has matured. The comments of Nobel Laureates on the previous editions reflect the long-held belief that central functional roles played by the diversity of glycan chains would be revealed by research in this field. Now, as the result of advances in analytical chemistry and much deeper understanding of genomes, cell and tissue organization, this field has arrived. The third edition of Essentials of Glycobiology stands as the authoritative treatise on the subject, covering all aspects of the field and written by the world leaders in current research."

—James E. Rothman, Nobel Laureate in Medicine, 2013

"Difficult to analyze and synthesize artificially, glycans are often simply ignored. To do so is to avert one's gaze from an important part of life. More than mere decoration, glycans magnify the diversity of the already diverse molecules to which they are attached, affect protein folding and stability, direct traffic within cells, serve as signposts of self vs. non-self, create barriers that protect us, and conversely, defend microbes, making some of them the pathogens they are. It is hard to imagine a world without complex sugars, but if such a world existed, it would be much diminished. The third edition of Essentials of Glycobiology may be life changing for scientists who have not yet engaged with glycobiology and will certainly be a treasured resource for those who already have."

—Bruce Beutler, Nobel Laureate in Medicine, 2011

"The importance of glycans has long been recognized and great advances have been reported on the synthesis and chemical analysis of this class of natural compounds. In my field, structural biology, carbohydrate moieties in glycoproteins and in complex multi-component macromolecular systems have been and continue to be difficult to handle. I greatly welcome the effort made in this multiauthor volume to present results obtained with methods of structural biology in the context of the wealth of currently available chemical and biological data. I recommend the third edition of Essentials of Glycobiology as a highly useful reference on the current state of the field."

—Kurt Wuethrich, Nobel Laureate in Chemistry, 2002

"We think conventionally of the immune system as having evolved to deal with invading pathogens that express "foreign" proteins (and peptides), targeted via specific recognition units, particularly secreted antibodies and cell-bound T lymphocyte receptors. As the molecular revolution has unfolded, such science that relies on a reasonably direct correlation between genotype and phenotype has been relatively straightforward. Much more difficult to assess is the part played by glycosylation profiles in immune recognition and pathogen elimination. Perhaps even more intriguing is the issue of glycan abnormalities and recognition in cancer and many other disease processes. Now, in a third edition of Essentials of Glycobiology written by authoritative leaders in the field, we learn how this knowledge has been rapidly advancing, and see possibilities for real breakthroughs in understanding and therapy."

—Peter C. Doherty, Nobel Laureate in Medicine 1996


Consultant Reviewers
Classic Books and Monographs
1 Historical Background and Overview
Ajit Varki and Stuart Kornfeld
2 Monosaccharide Diversity
Peter H. Seeberger
3 Oligosaccharides and Polysaccharides
James H. Prestegard, Jian Liu, and Göran Widmalm
4 Cellular Organization of Glycosylation
Karen J. Colley, Ajit Varki, and Taroh Kinoshita
5 Glycosylation Precursors
Hudson H. Freeze, Gerald W. Hart, and Ronald L. Schnaar
6 Glycosyltransferases and Glycan-Processing Enzymes
James M. Rini and Jeffrey D. Esko
7 Biological Functions of Glycans
Ajit Varki and Pascal Gagneux
8 A Genomic View of Glycobiology
Bernard Henrissat, Avadesha Surolia, and Pamela Stanley
9 N-Glycans
Pamela Stanley, Naoyuki Taniguchi, and Markus Aebi
10 O-GalNAc Glycans
Inka Brockhausen and Pamela Stanley
11 Glycosphingolipids
Ronald L. Schnaar and Taroh Kinoshita
12 Glycosylphosphatidylinositol Anchors
Michael A.J. Ferguson, Gerald W. Hart, and Taroh Kinoshita
13 Other Classes of Eukaryotic Glycans
Robert S. Haltiwanger, Lance Wells, Hudson H. Freeze, and Pamela Stanley
14 Structures Common to Different Glycans
Pamela Stanley and Richard D. Cummings
15 Sialic Acids and Other Nonulosonic Acids
Ajit Varki, Ronald L. Schnaar, and Roland Schauer
16 Hyaluronan
Vincent Hascall and Jeffrey D. Esko
17 Proteoglycans and Sulfated Glycosaminoglycans
Ulf Lindahl, John Couchman, Koji Kimata, and Jeffrey D. Esko
18 Nucleocytoplasmic Glycosylation
Christopher M. West and Gerald W. Hart
19 The O-GlcNAc Modification
Natasha Zachara, Yoshihiro Akimoto, and Gerald W. Hart
20 Evolution of Glycan Diversity
Pascal Gagneux, Markus Aebi, and Ajit Varki
21 Eubacteria
Chris Whitfield, Christine M. Szymanski, and Markus Aebi
22 Archaea
Sonja Albers, Jerry Eichler, and Markus Aebi
23 Fungi
Tamara L. Doering, Richard D. Cummings, and Markus Aebi
24 Viridiplantae and Algae
Malcolm A. O'Neill, Alan G. Darvill, Marilynn E. Etzler, Debra Mohnen, and Serge Perez
25 Nematoda
Iain B.H. Wilson, Richard D. Cummings, and Markus Aebi
26 Arthropoda
Michael Tiemeyer, Hiroshi Nakato, and Jeffrey D. Esko
27 Deuterostomes
Michael Pierce and Pamela Stanley
28 Discovery and Classification of Glycan-Binding Proteins
Maureen E. Taylor, Kurt Drickamer, Ronald L. Schnaar, Marilynn E. Etzler, and Ajit Varki
29 Principles of Glycan Recognition
Richard D. Cummings, Ronald L. Schnaar, Jeffrey D. Esko, Kurt Drickamer, and Maureen E. Taylor
30 Structural Biology of Glycan Recognition
Anne Imberty and James H. Prestegard
31 R-Type Lectins
Richard D. Cummings and Ronald L. Schnaar
32 L-Type Lectins
Richard D. Cummings, Marilynn E. Etzler, and Avadhesha Surolia
33 P-Type Lectins
Ajit Varki and Stuart Kornfeld
34 C-Type Lectins
Richard D. Cummings and Rodger P. McEver
35 I-Type Lectins
Ajit Varki, Ronald L. Schnaar, and Paul R. Crocker
36 Galectins
Richard D. Cummings, Fu-Tong Liu, and Gerardo R. Vasta
37 Microbial Lectins: Hemagglutinins, Adhesins, and Toxins
Victor Nizet, Ajit Varki, and Markus Aebi
38 Proteins That Bind Sulfated Glycosaminoglycans
Jeffrey D. Esko, James H. Prestegard, and Robert J. Linhardt
39 Glycans in Glycoprotein Quality Control
Armando Parodi, Richard D. Cummings, and Markus Aebi
40 Free Glycans as Signaling Molecules
Malcolm A. O'Neill, Alan G. Darvill, Marilynn E. Etzler, and Jeffrey D. Esko
41 Glycans in Systemic Physiology
Hudson H. Freeze, Linda Baum, and Ajit Varki
42 Bacterial and Viral Infections
Christine M. Szymanski, Ronald L. Schnaar, and Markus Aebi
43 Parasitic Infections
Richard D. Cummings and Irma van Die
44 Genetic Disorders of Glycan Degradation
Hudson H. Freeze, Taroh Kinoshita, and Ronald L. Schnaar
45 Genetic Disorders of Glycosylation
Hudson H. Freeze, Harry Schachter, and Taroh Kinoshita
46 Glycans in Acquired Human Diseases
Hudson H. Freeze, Taroh Kinoshita, and Ajit Varki
47 Glycosylation Changes in Cancer
Ajit Varki, Reiji Kannagi, Bryan Toole, and Pamela Stanley
48 Glycan-Recognizing Probes as Tools
Richard D. Cummings, Alan G. Darvill, Marilynn E. Etzler, and Michael G. Hahn
49 Glycosylation Mutants of Cultured Mammalian Cells
Jeffrey D. Esko and Pamela Stanley
50 Structural Analysis of Glycans
Barbara Mulloy, Anne Dell, Pamela Stanley, and James H. Prestegard
51 Glycomics and Glycoproteomics
Pauline Rudd, Niclas G. Karlsson, Kay-Hooi Khoo, and Nicolle H. Packer
52 Glycoinformatics
Matthew P. Campbell, Kiyoko F. Aoki-Kinoshita, Frederique Lisacek, William S. York, and Nicolle H. Packer
53 Chemical Synthesis of Glycans and Glycoconjugates
Peter H. Seeberger and Hermen S. Overkleeft
54 Chemoenzymatic Synthesis of Glycans and Glycoconjugates
Hermen S. Overkleeft and Peter H. Seeberger
55 Chemical Tools for Inhibiting Glycosylation
Jeffrey D. Esko, Carolyn Bertozzi, and Ronald L. Schnaar
56 Glycosylation Engineering
Henrik Clausen, Hans H. Wandall, Catharina Steentoft, Pamela Stanley, and Ronald L. Schnaar
57 Glycans in Biotechnology and the Pharmaceutical Industry
Peter H. Seeberger and Richard D. Cummings
58 Glycans in Nanotechnology
Soledad Penadés, Benjamin G. Davis, and Peter H. Seeberger
59 Glycans in Bioenergy and Materials Science
Malcolm A. O'Neill, Robert J. Moon, William S. York, and Alan G. Darvill
60 Future Directions in Glycosciences
Gerald W. Hart and Ajit Varki
Study Guide