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The Biology of the TGF-β Family


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyCell BiologyImmunology and Vaccines

Edited by Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

Download a Free Excerpt from The Biology of the TGF-β Family:

Preface
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
Index


© 2017 • 1164 pages, illustrated (149 color and 8 B&W), index
Hardcover • $135 108.00 (click here to price in UK Pounds)
ISBN  978-1-621820-36-9
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  •     Description    
  •     Contents    

Description

The transforming growth factor β (TGF-β) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF-β family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF-β signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive view of the different members of the TGF-β family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF-β family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF-β and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF-β signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF-β signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered.

The authors also review TGF-β signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF-β and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF-β family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research.

Contents

Preface
The Discovery and Early Days of TGF-β: A Historical Perspective
Harold L. Moses, Anita B. Roberts, and Rik Derynck
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
Masato Morikawa, Rik Derynck, and Kohei Miyazono
Activins and Inhibins: Roles in Development, Physiology, and Disease
Maria Namwanje and Chester W. Brown
Bone Morphogenetic Proteins
Takenobu Katagiri and Tetsuro Watabe
Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
Ian B. Robertson and Daniel B. Rifkin
Agonists and Antagonists of TGF-β Family Ligands
Chenbei Chang
Signaling Receptors for TGF-β Family Members
Carl-Henrik Heldin and Aristidis Moustakas
Structural Biology and Evolution of theTGF-β Family
Andrew P. Hinck, Thomas D. Mueller, and Timothy A. Springer
TGF-β Signaling from Receptors to Smads
Akiko Hata and Ye-Guang Chen
Transcriptional Control by the SMADs
Caroline S. Hill
Posttranslational Regulation of Smads
Pinglong Xu, Xia Lin, and Xin-Hua Feng
Regulation of TGF-β Family Signaling by Inhibitory Smads
Keiji Miyazawa and Kohei Miyazono
Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads
Apirat Chaikuad and Alex N. Bullock
Non-Smad Signaling Pathways of the TGF-β Family
Ying E. Zhang
Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways
Kunxin Luo
TGF-β Family Signaling in the Control of Cell Proliferation and Survival
Yun Zhang, Peter B. Alexander, and Xiao-Fan Wang
TGF-β Family Signaling in Drosophila
Ambuj Upadhyay, Lindsay Moss-Taylor, Myung-Jun Kim, Arpan C. Ghosh, and Michael B. O’Connor
The TGF-β Family in Caenorhabditis elegans
Cathy Savage-Dunn and Richard W. Padgett
TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation
Alan C. Mullen and Jeffrey L. Wrana
TGF-β Family Signaling in Early Vertebrate Development
Joseph Zinski, Benjamin Tajer, and Mary C. Mullins
TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition
Kaoru Kahata, Mahsa Shahidi Dadras, and Aristidis Moustakas
TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis
Kaoru Kahata, Varun Maturi, and Aristidis Moustakas
TGF-β Family Signaling in Mesenchymal Differentiation
Ingo Grafe, Stefanie Alexander, Jonathan R. Peterson, Taylor Nicholas Snider, Benjamin Levi, Brendan Lee, and Yuji Mishina
TGF-β Family Signaling in Control of Cardiovascular Function
Marie-José Goumans and Peter ten Dijke
Bone Morphogenetic Proteins in Vascular Homeostasis and Disease
Marie-José Goumans, An Zwijsen, Peter ten Dijke, and Sabine Bailly
Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling Molecules
Kazuhito Naka and Atsushi Hirao
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
Shomyseh Sanjabi, Soyoung A. Oh, and Ming O. Li
TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function
Emily A. Meyers and John A. Kessler
The TGF-β Family in the Reproductive Tract
Diana Monsivais, Martin M. Matzuk, and Stephanie A. Pangas
TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Elena Gallo MacFarlane, Julia Haupt, Harry C. Dietz, and Eileen M. Shore
TGF-β1 Signaling and Tissue Fibrosis
Kevin K. Kim, Dean Sheppard, and Harold A. Chapman
TGF-β Family Signaling in Tumor Suppression and Cancer Progression
Joan Seoane and Roger R. Gomis
TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment
Michael W. Pickup, Philip Owens, and Harold L. Moses
Targeting TGF-β Signaling for Therapeutic Gain
Rosemary J. Akhurst
Bone Morphogenetic Protein–Based Therapeutic Approaches
Jonathan W. Lowery and Vicki Rosen
Index