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The Digital Cell: Cell Biology as a Data Science


Subject Area(s):  BioinformaticsCell BiologyMolecular BiologyHandbooks

By Stephen J. Royle, University of Warwick Medical Center

© 2020 • 137 pages, illustrated (2 color and 26 B&W), index
Hardcover • $61 48.80
ISBN  978-1-621822-78-3
You save: 20%
You will receive free shipping on this item at checkout.
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Print Book + eBook
    Best value!
$116.51 $54.90 Add To Cart
Print Book$61 $48.80 Add To Cart
eBook$55.51 $41.63 Add To Cart

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eBooks use Adobe Digital Editions software. Click here for more information.

  •     Description    
  •     Contents    

Description

Cell and molecular biology are becoming increasingly data driven. Technological advances and increased computing power mean that researchers now increasingly quantify experimental results, rather than simply report qualitative, representative observations. The Digital Cell provides a comprehensive guide for scientists seeking to make this transition. It describes how data should be generated and processed, discussing research workflows, pipelines, and storage solutions. A key focus of the book is imaging—image types and formats are explained, as is software for image processing and analysis, along with techniques such as segmentation analysis and automated particle tracking.

The book examines the wide variety of statistical approaches that can be used for data analysis, emphasizing concepts such as significance and reproducibility. It also includes an introduction to coding, including examples of how to write and use R scripts to analyze results. In addition, there is useful advice on how to plot and present data to convey results most effectively. The Digital Cell is thus an essential resource for all cell and molecular biologists—from students embarking on research for the first time to experienced scientists who need to acquire, process, and present their data accurately and efficiently.

Contents

Preface
Acknowledgments
1. The Digital Cell Philosophy
Workflows and Pipelines
Using Spreadsheets for Experimental Data
Software for Digital Cell Biology
Focusing on Imaging
Golden Rules
2. Dealing with Data
Why Is Organization So Important?
Getting Organized
Experiment-Based Organization
Databases for Resources
Electronic Lab Notebooks (ELNs)
Databases for Imaging Data
Sharing Your Data Externally
Backing Up Your Data
Golden Rules

3. Imaging Data
Software Selection
Fiji
RStudio
What Is an Image?
Image Formats
Image Types
Multidimensional Image Files
Metadata
Image Transformation
Imaging Information
Trade-Offs in Imaging
Focus and Dealing with Drift
Phototoxicity and Photobleaching
Choice of Fluorophores
Dynamic Range
Golden Rules
4. Image Processing and Analysis
How to Analyze an Image
Tutorial: Quantifying Cell Protein Levels from Immunofluorescence Images
Segmentation
Further Segmentation Approaches
Image Filters
Gel Densitometry
Tutorial: Quantifying Bands on a Gel
How to Analyze a Movie
Tutorial: Counting Vesicles in Cells
Particle Tracking
Tutorial: Manual Particle Tracking
Tutorial: Automated Particle Tracking
Kymographs
Tutorial: Generating a Kymograph
Colocalization
Tutorial: Using R to Measure Colocalization over Time
Getting the Right Data Out of the Image
Validation
Back to Square One
Golden Rules
5. Statistics
Designing an experiment
What Is n?
Golden Rules
Why Does n Matter?
Power Analysis for Cell Biologists
Basic Statistics That You Will Need
A Refresher of Summary Statistics
Always Plot Out Your Data
Descriptive Statistics
Statistical Tests
Compare One Group to a Value
Compare Two Groups
Comparing Three or More Groups
More Complicated Experimental Designs
Problems with Data
The p-Value
What It Really Means
Statistically Significant versus Biologically Significant
Effect Size
Golden Rules
6. Coding
Where to Start
Basic Principles: Workflow, Reproducibility, and Benefits
Mastering the Command Line
Getting Started with Coding
Variables and Strings
Arrays and Vectors
Loops
How to Write a Basic ImageJ Macro
Working on All Files in a Directory
Tutorial: Blinding Files for Manual Image Analysis
How to Write a Basic R Script for Analysis
What Can Go Wrong?
How to Validate and Check Your Data
Debugging
Getting Help
Getting Good
Ugly Code
Write Modular Code
Version Control and git
Sharing Your Code
Golden Rules
7. Putting It Together
Plotting Data
Best Practice
Making Figures
Best Practice
Making Figures That Look Great
Color Blindness
Contrast Adjustments
Crops and Expansion
Scale Bars
Movie Files
Unacceptable Manipulation in Figures
Golden Rules
Appendix: List of Software Featured in This Book
Bibliography
Index
Add To Cart  Add this Title to Order List 
   
Click to Enlarge

The Digital Cell: Cell Biology as a Data Science

Cell and molecular biology are becoming increasingly data driven. Technological advances and increased computing power mean that researchers now increasingly quantify experimental results, rather than simply report qualitative, representative observations. The Digital Cell provides a comprehensive guide for scientists seeking to make this transition. It describes how data should be generated and processed, discussing research workflows, pipelines, and storage solutions. A key focus of the book is imaging—image types and formats are explained, as is software for image processing and analysis, along with techniques such as segmentation analysis and automated particle tracking.

The book examines the wide variety of statistical approaches that can be used for data analysis, emphasizing concepts such as significance and reproducibility. It also includes an introduction to coding, including examples of how to write and use R scripts to analyze results. In addition, there is useful advice on how to plot and present data to convey results most effectively. The Digital Cell is thus an essential resource for all cell and molecular biologists—from students embarking on research for the first time to experienced scientists who need to acquire, process, and present their data accurately and efficiently.

More INFO Below
Description
Contents
   

© 2020 • 137 pages, illustrated (2 color and 26 B&W), index
Hardcover • $55.51 • ISBN 978-1-621822-78-3


 

Description

Cell and molecular biology are becoming increasingly data driven. Technological advances and increased computing power mean that researchers now increasingly quantify experimental results, rather than simply report qualitative, representative observations. The Digital Cell provides a comprehensive guide for scientists seeking to make this transition. It describes how data should be generated and processed, discussing research workflows, pipelines, and storage solutions. A key focus of the book is imaging—image types and formats are explained, as is software for image processing and analysis, along with techniques such as segmentation analysis and automated particle tracking.

The book examines the wide variety of statistical approaches that can be used for data analysis, emphasizing concepts such as significance and reproducibility. It also includes an introduction to coding, including examples of how to write and use R scripts to analyze results. In addition, there is useful advice on how to plot and present data to convey results most effectively. The Digital Cell is thus an essential resource for all cell and molecular biologists—from students embarking on research for the first time to experienced scientists who need to acquire, process, and present their data accurately and efficiently.

 
Add To Cart  Add this Title to Order List 
 

Contents

Preface
Acknowledgments
1. The Digital Cell Philosophy
Workflows and Pipelines
Using Spreadsheets for Experimental Data
Software for Digital Cell Biology
Focusing on Imaging
Golden Rules
2. Dealing with Data
Why Is Organization So Important?
Getting Organized
Experiment-Based Organization
Databases for Resources
Electronic Lab Notebooks (ELNs)
Databases for Imaging Data
Sharing Your Data Externally
Backing Up Your Data
Golden Rules

3. Imaging Data
Software Selection
Fiji
RStudio
What Is an Image?
Image Formats
Image Types
Multidimensional Image Files
Metadata
Image Transformation
Imaging Information
Trade-Offs in Imaging
Focus and Dealing with Drift
Phototoxicity and Photobleaching
Choice of Fluorophores
Dynamic Range
Golden Rules
4. Image Processing and Analysis
How to Analyze an Image
Tutorial: Quantifying Cell Protein Levels from Immunofluorescence Images
Segmentation
Further Segmentation Approaches
Image Filters
Gel Densitometry
Tutorial: Quantifying Bands on a Gel
How to Analyze a Movie
Tutorial: Counting Vesicles in Cells
Particle Tracking
Tutorial: Manual Particle Tracking
Tutorial: Automated Particle Tracking
Kymographs
Tutorial: Generating a Kymograph
Colocalization
Tutorial: Using R to Measure Colocalization over Time
Getting the Right Data Out of the Image
Validation
Back to Square One
Golden Rules
5. Statistics
Designing an experiment
What Is n?
Golden Rules
Why Does n Matter?
Power Analysis for Cell Biologists
Basic Statistics That You Will Need
A Refresher of Summary Statistics
Always Plot Out Your Data
Descriptive Statistics
Statistical Tests
Compare One Group to a Value
Compare Two Groups
Comparing Three or More Groups
More Complicated Experimental Designs
Problems with Data
The p-Value
What It Really Means
Statistically Significant versus Biologically Significant
Effect Size
Golden Rules
6. Coding
Where to Start
Basic Principles: Workflow, Reproducibility, and Benefits
Mastering the Command Line
Getting Started with Coding
Variables and Strings
Arrays and Vectors
Loops
How to Write a Basic ImageJ Macro
Working on All Files in a Directory
Tutorial: Blinding Files for Manual Image Analysis
How to Write a Basic R Script for Analysis
What Can Go Wrong?
How to Validate and Check Your Data
Debugging
Getting Help
Getting Good
Ugly Code
Write Modular Code
Version Control and git
Sharing Your Code
Golden Rules
7. Putting It Together
Plotting Data
Best Practice
Making Figures
Best Practice
Making Figures That Look Great
Color Blindness
Contrast Adjustments
Crops and Expansion
Scale Bars
Movie Files
Unacceptable Manipulation in Figures
Golden Rules
Appendix: List of Software Featured in This Book
Bibliography
Index
 

$49.96
This bundle includes the following products:

The Digital Cell: Cell Biology as a Data Science
Add To Cart  Add this Title to Order List 
   
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Metastasis: Mechanism to Therapy

Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations—will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.

Download a Free Excerpt from Metastasis: Mechanism to Therapy:

Preface
Normal Aging and Its Role in Cancer Metastasis
Index

More INFO Below
Description
Contents
   

© 2020 • 326 pages, illustrated (45 color), index
Hardcover • $75.00 • ISBN 978-1-621823-24-7


 

Description

Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations—will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.

 
Add To Cart  Add this Title to Order List 
 

Contents

Preface
Cancer Cell Dormancy in Metastasis
Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher
Premetastasis
Yoshiro Maru
Brain Metastasis Organotropism
Arseniy E. Yuzhalin and Dihua Yu
Bone Tropism in Cancer Metastases
Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-F. Zhang
Liver Tropism in Cancer: The Hepatic Metastatic Niche
Ainhoa Mielgo and Michael C. Schmid
Normal Aging and Its Role in Cancer Metastasis
Mitchell Fane and Ashani T. Weeraratna
The Immune Microenvironment and Cancer Metastasis
Asmaa El-Kenawi, Kay Hänggi, and Brian Ruffell
Myeloid Cells in Metastasis
Agnieszka Swierczak and Jeffrey W. Pollard
Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages
Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mazzone
Extracellular Vesicles and Metastasis
Shizhen Emily Wang
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
Toni Celià-Terrassa and Mohit Kumar Jolly
Clinical Perspectives in Brain Metastasis
Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and Josh Neman
New Approaches on Cancer Immunotherapy
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and Mien-Chie Hung
The Etiology and Impact of Muscle Wasting in Metastatic Cancer
Anup K. Biswas and Swarnali Acharyya
The Different Facets of Liquid Biopsy: A Kaleidoscopic View
Zahra Eslami-S, Luis Enrique Cortés-Hernández, Laure Cayrefourcq, and Catherine Alix-Panabières
Zebrafish In Vivo Models of Cancer and Metastasis
Katy R. Astell and Dirk Sieger
Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy
Andreia S. Margarido, Laura Bornes, Claire Vennin, and Jacco van Rheenen
Index
 

$67.50
This bundle includes the following products:

Metastasis: Mechanism to Therapy
   

Click to Enlarge

Metastasis: Mechanism to Therapy


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Jeffrey W. Pollard, The University of Edinburgh; Yibin Kang, Princeton University

Download a Free Excerpt from Metastasis: Mechanism to Therapy:

Preface
Normal Aging and Its Role in Cancer Metastasis
Index


© 2020 • 326 pages, illustrated (45 color), index
Hardcover • $135 94.50
ISBN  978-1-621823-24-7
You save: 30%
You will receive free shipping on this item at checkout.
Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Print Book + eBook
    Best value!
$210 $121.50 Add To Cart
Print Book$135 $94.50 Add To Cart
eBook$75 $60.00 Add To Cart

Bulk discounts available for your lab or class. Click here to inquire.

eBooks use Adobe Digital Editions software. Click here for more information.

  •     Description    
  •     Contents    

Description

Nearly all types of cancer have the ability to metastasize, or spread from one organ or tissue in the body to another. Metastatic disease is responsible for the majority of cancer deaths and, therefore, is a critical area of research. Work to better understand the metastatic cascade—how cells detach from a primary tumor, migrate through the body, and seed secondary tumors at distant locations—will lead to improved treatment options for patients with cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the molecular mechanisms underlying metastasis and how this knowledge is paving the way for new therapeutic targets. The contributors discuss progress in defining mutations that might be driving metastasis, the formation of a premetastatic niche and how it enhances the establishment of a secondary tumor, and how changes that occur during aging increase the metastatic capacity of tumor cells. They also consider the selection and colonization of common target organs (e.g., brain, liver, and bones) during metastasis and the roles of immune cells and extracellular vesicles at different steps of the metastatic cascade. Cellular plasticity—including evidence for metastatic stem cells and the role of tumor cell dormancy in recurrent metastasis—is also covered.

In addition, the authors describe the development of in vivo models and techniques for studying metastasis, methods for monitoring tumor progression and metastatic spread (e.g., intravital microscopy and liquid biopsy), and immunotherapies that can potentially target cancer metastasis. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating cancer.

Contents

Preface
Cancer Cell Dormancy in Metastasis
Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher
Premetastasis
Yoshiro Maru
Brain Metastasis Organotropism
Arseniy E. Yuzhalin and Dihua Yu
Bone Tropism in Cancer Metastases
Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-F. Zhang
Liver Tropism in Cancer: The Hepatic Metastatic Niche
Ainhoa Mielgo and Michael C. Schmid
Normal Aging and Its Role in Cancer Metastasis
Mitchell Fane and Ashani T. Weeraratna
The Immune Microenvironment and Cancer Metastasis
Asmaa El-Kenawi, Kay Hänggi, and Brian Ruffell
Myeloid Cells in Metastasis
Agnieszka Swierczak and Jeffrey W. Pollard
Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages
Nina C. Flerin, Sotiria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mazzone
Extracellular Vesicles and Metastasis
Shizhen Emily Wang
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
Toni Celià-Terrassa and Mohit Kumar Jolly
Clinical Perspectives in Brain Metastasis
Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and Josh Neman
New Approaches on Cancer Immunotherapy
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and Mien-Chie Hung
The Etiology and Impact of Muscle Wasting in Metastatic Cancer
Anup K. Biswas and Swarnali Acharyya
The Different Facets of Liquid Biopsy: A Kaleidoscopic View
Zahra Eslami-S, Luis Enrique Cortés-Hernández, Laure Cayrefourcq, and Catherine Alix-Panabières
Zebrafish In Vivo Models of Cancer and Metastasis
Katy R. Astell and Dirk Sieger
Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy
Andreia S. Margarido, Laura Bornes, Claire Vennin, and Jacco van Rheenen
Index
Add To Cart  Add this Title to Order List 
   
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Genetic Counseling: Clinical Practice and Ethical Considerations

Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.

This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.

Download a Free Excerpt from Genetic Counseling: Clinical Practice and Ethical Considerations:

Genetic Counseling and the Central Tenets of Practice
Index

More INFO Below
Description
Contents
   

© 2020 • 304 pages, illustrated (11 color and 1 B&W), index
Paperback • $75.00 • ISBN 978-1-621823-96-4


 

Description

Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.

This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.

 
Add To Cart  Add this Title to Order List 
 

Contents

Genetic Counseling and the Central Tenets of Practice
Barbara Biesecker
PRENATAL
Supporting Patient Autonomy and Informed Decision-Making in Prenatal Genetic Testing
Katie Stoll and Judith Jackson
Impact of Emerging Technologies in Prenatal Genetic Counseling
Blair Stevens
NEUROLOGY
Predictive Genetic Counseling and Testing for Neurodegenerative Diseases: Past, Present, and Future
Jill S. Goldman
Genetic Counseling in Neurodevelopmental Disorders
Alyssa Blesson and Julie S. Cohen 
CANCER
Cancer Genetic Counseling—Current Practice and Future Challenges
Jaclyn Schienda and Jill Stopfer
Tumor-Based Genetic Testing and Familial Cancer Risk
Andrea Forman and Jilliane Sotelo
PSYCHIATRY
Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map
Jehannine C. Austin
Genetic Risk Assessment in Psychiatry
Holly Landrum Peay
CARDIOLOGY
Psychological Issues in Managing Families with Inherited Cardiovascular Diseases
Jodie Ingles
A Person-Centered Approach to Cardiovascular Genetic Testing
Julia Platt
PEDIATRICS
Genetic Counseling for Genome Sequencing in Pediatric Rare Disease
Alison M. Elliott
Bridging the Gap between Scientific Advancement and Real-World Application: Pediatric Genetic Counseling for Common Syndromes and Single-Gene Disorders
Julie A. McGlynn and Elinor Langfelder-Schwind
INFERTILITY
Genetic Counseling and Assisted Reproductive Technologies
Debra Lilienthal and Michelle Cahr
ETHICAL, LEGAL AND SOCIAL ISSUES
Discouraging Elective Genetic Testing of Minors: A Norm under Siege in a New Era of Genomic Medicine
Laura Hercher
Legal Challenges in Genetics, Including Duty to Warn, and Genetic Discrimination
Sonia Suter
Birds of a Feather? Genetic Counseling, Genetic Testing, and Humanism
Robert Resta
Regulating Preimplantation Genetic Testing across the World: A Comparison of International Policy and Ethical Perspectives
Margaret E.C. Ginoza and Rosario Isasi
GENOMICS
Evolving Roles of Genetic Counselors in the Clinical Laboratory
Megan T. Cho and Carrie Guy
Informed Consent in the Genomics Era
Shannon Rego, Megan E. Grove, Mildred K. Cho, and Kelly E. Ormond
THE FUTURE OF THE PROFESSION
Genetic Counseling, Personalized Medicine, and Precision Health
Erica Ramos
Index
 

$67.50
This bundle includes the following products:

Genetic Counseling: Clinical Practice and Ethical Considerations
Add To Cart  Add this Title to Order List 
   
Click to Enlarge

Genetic Counseling: Clinical Practice and Ethical Considerations

Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.

This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseGenetics

Download a Free Excerpt from Genetic Counseling: Clinical Practice and Ethical Considerations:

Genetic Counseling and the Central Tenets of Practice
Index

More INFO Below
Description
Contents
   

© 2020 • 304 pages, illustrated (11 color and 1 B&W), index
Hardcover • $75.00 • ISBN 978-1-621823-47-6


 

Description

Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.

This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.

 
Add To Cart  Add this Title to Order List 
 

Contents

Genetic Counseling and the Central Tenets of Practice
Barbara Biesecker
PRENATAL
Supporting Patient Autonomy and Informed Decision-Making in Prenatal Genetic Testing
Katie Stoll and Judith Jackson
Impact of Emerging Technologies in Prenatal Genetic Counseling
Blair Stevens
NEUROLOGY
Predictive Genetic Counseling and Testing for Neurodegenerative Diseases: Past, Present, and Future
Jill S. Goldman
Genetic Counseling in Neurodevelopmental Disorders
Alyssa Blesson and Julie S. Cohen 
CANCER
Cancer Genetic Counseling—Current Practice and Future Challenges
Jaclyn Schienda and Jill Stopfer
Tumor-Based Genetic Testing and Familial Cancer Risk
Andrea Forman and Jilliane Sotelo
PSYCHIATRY
Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map
Jehannine C. Austin
Genetic Risk Assessment in Psychiatry
Holly Landrum Peay
CARDIOLOGY
Psychological Issues in Managing Families with Inherited Cardiovascular Diseases
Jodie Ingles
A Person-Centered Approach to Cardiovascular Genetic Testing
Julia Platt
PEDIATRICS
Genetic Counseling for Genome Sequencing in Pediatric Rare Disease
Alison M. Elliott
Bridging the Gap between Scientific Advancement and Real-World Application: Pediatric Genetic Counseling for Common Syndromes and Single-Gene Disorders
Julie A. McGlynn and Elinor Langfelder-Schwind
INFERTILITY
Genetic Counseling and Assisted Reproductive Technologies
Debra Lilienthal and Michelle Cahr
ETHICAL, LEGAL AND SOCIAL ISSUES
Discouraging Elective Genetic Testing of Minors: A Norm under Siege in a New Era of Genomic Medicine
Laura Hercher
Legal Challenges in Genetics, Including Duty to Warn, and Genetic Discrimination
Sonia Suter
Birds of a Feather? Genetic Counseling, Genetic Testing, and Humanism
Robert Resta
Regulating Preimplantation Genetic Testing across the World: A Comparison of International Policy and Ethical Perspectives
Margaret E.C. Ginoza and Rosario Isasi
GENOMICS
Evolving Roles of Genetic Counselors in the Clinical Laboratory
Megan T. Cho and Carrie Guy
Informed Consent in the Genomics Era
Shannon Rego, Megan E. Grove, Mildred K. Cho, and Kelly E. Ormond
THE FUTURE OF THE PROFESSION
Genetic Counseling, Personalized Medicine, and Precision Health
Erica Ramos
Index
 

$67.50
This bundle includes the following products:

Genetic Counseling: Clinical Practice and Ethical Considerations
   

Click to Enlarge

Genetic Counseling: Clinical Practice and Ethical Considerations


Subject Area(s):  Human Biology and DiseaseGenetics

Edited by Laura Hercher, Sarah Lawrence College; Barbara Biesecker, Research Triangle Institute (RTI) International; Jehannine C. Austin, University of British Columbia

Download a Free Excerpt from Genetic Counseling: Clinical Practice and Ethical Considerations:

Genetic Counseling and the Central Tenets of Practice
Index


© 2020 • 304 pages, illustrated (11 color and 1 B&W), index
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ISBN  978-1-621823-96-4
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  •     Description    
  •     Contents    

Description

Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.

This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.

Contents

Genetic Counseling and the Central Tenets of Practice
Barbara Biesecker
PRENATAL
Supporting Patient Autonomy and Informed Decision-Making in Prenatal Genetic Testing
Katie Stoll and Judith Jackson
Impact of Emerging Technologies in Prenatal Genetic Counseling
Blair Stevens
NEUROLOGY
Predictive Genetic Counseling and Testing for Neurodegenerative Diseases: Past, Present, and Future
Jill S. Goldman
Genetic Counseling in Neurodevelopmental Disorders
Alyssa Blesson and Julie S. Cohen 
CANCER
Cancer Genetic Counseling—Current Practice and Future Challenges
Jaclyn Schienda and Jill Stopfer
Tumor-Based Genetic Testing and Familial Cancer Risk
Andrea Forman and Jilliane Sotelo
PSYCHIATRY
Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map
Jehannine C. Austin
Genetic Risk Assessment in Psychiatry
Holly Landrum Peay
CARDIOLOGY
Psychological Issues in Managing Families with Inherited Cardiovascular Diseases
Jodie Ingles
A Person-Centered Approach to Cardiovascular Genetic Testing
Julia Platt
PEDIATRICS
Genetic Counseling for Genome Sequencing in Pediatric Rare Disease
Alison M. Elliott
Bridging the Gap between Scientific Advancement and Real-World Application: Pediatric Genetic Counseling for Common Syndromes and Single-Gene Disorders
Julie A. McGlynn and Elinor Langfelder-Schwind
INFERTILITY
Genetic Counseling and Assisted Reproductive Technologies
Debra Lilienthal and Michelle Cahr
ETHICAL, LEGAL AND SOCIAL ISSUES
Discouraging Elective Genetic Testing of Minors: A Norm under Siege in a New Era of Genomic Medicine
Laura Hercher
Legal Challenges in Genetics, Including Duty to Warn, and Genetic Discrimination
Sonia Suter
Birds of a Feather? Genetic Counseling, Genetic Testing, and Humanism
Robert Resta
Regulating Preimplantation Genetic Testing across the World: A Comparison of International Policy and Ethical Perspectives
Margaret E.C. Ginoza and Rosario Isasi
GENOMICS
Evolving Roles of Genetic Counselors in the Clinical Laboratory
Megan T. Cho and Carrie Guy
Informed Consent in the Genomics Era
Shannon Rego, Megan E. Grove, Mildred K. Cho, and Kelly E. Ormond
THE FUTURE OF THE PROFESSION
Genetic Counseling, Personalized Medicine, and Precision Health
Erica Ramos
Index
   

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Genetic Counseling: Clinical Practice and Ethical Considerations


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseGenetics

Edited by Laura Hercher, Sarah Lawrence College; Barbara Biesecker, Research Triangle Institute (RTI) International; Jehannine C. Austin, University of British Columbia

Download a Free Excerpt from Genetic Counseling: Clinical Practice and Ethical Considerations:

Genetic Counseling and the Central Tenets of Practice
Index


© 2020 • 304 pages, illustrated (11 color and 1 B&W), index
Hardcover • $135 94.50
ISBN  978-1-621823-47-6
You save: 30%
You will receive free shipping on this item at checkout.
Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

This title also available in: Paperback

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    Best value!
$210 $121.50 Add To Cart
Print Book$135 $94.50 Add To Cart
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  •     Description    
  •     Contents    

Description

Genetic counselors advise patients and families affected by or at risk of genetic disorders. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions. The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice.

This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age. The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different counseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues (e.g., genetic testing of minors, genetic discrimination, and obtaining informed consent for genomic testing), as well as the future of the profession. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.

Contents

Genetic Counseling and the Central Tenets of Practice
Barbara Biesecker
PRENATAL
Supporting Patient Autonomy and Informed Decision-Making in Prenatal Genetic Testing
Katie Stoll and Judith Jackson
Impact of Emerging Technologies in Prenatal Genetic Counseling
Blair Stevens
NEUROLOGY
Predictive Genetic Counseling and Testing for Neurodegenerative Diseases: Past, Present, and Future
Jill S. Goldman
Genetic Counseling in Neurodevelopmental Disorders
Alyssa Blesson and Julie S. Cohen 
CANCER
Cancer Genetic Counseling—Current Practice and Future Challenges
Jaclyn Schienda and Jill Stopfer
Tumor-Based Genetic Testing and Familial Cancer Risk
Andrea Forman and Jilliane Sotelo
PSYCHIATRY
Evidence-Based Genetic Counseling for Psychiatric Disorders: A Road Map
Jehannine C. Austin
Genetic Risk Assessment in Psychiatry
Holly Landrum Peay
CARDIOLOGY
Psychological Issues in Managing Families with Inherited Cardiovascular Diseases
Jodie Ingles
A Person-Centered Approach to Cardiovascular Genetic Testing
Julia Platt
PEDIATRICS
Genetic Counseling for Genome Sequencing in Pediatric Rare Disease
Alison M. Elliott
Bridging the Gap between Scientific Advancement and Real-World Application: Pediatric Genetic Counseling for Common Syndromes and Single-Gene Disorders
Julie A. McGlynn and Elinor Langfelder-Schwind
INFERTILITY
Genetic Counseling and Assisted Reproductive Technologies
Debra Lilienthal and Michelle Cahr
ETHICAL, LEGAL AND SOCIAL ISSUES
Discouraging Elective Genetic Testing of Minors: A Norm under Siege in a New Era of Genomic Medicine
Laura Hercher
Legal Challenges in Genetics, Including Duty to Warn, and Genetic Discrimination
Sonia Suter
Birds of a Feather? Genetic Counseling, Genetic Testing, and Humanism
Robert Resta
Regulating Preimplantation Genetic Testing across the World: A Comparison of International Policy and Ethical Perspectives
Margaret E.C. Ginoza and Rosario Isasi
GENOMICS
Evolving Roles of Genetic Counselors in the Clinical Laboratory
Megan T. Cho and Carrie Guy
Informed Consent in the Genomics Era
Shannon Rego, Megan E. Grove, Mildred K. Cho, and Kelly E. Ormond
THE FUTURE OF THE PROFESSION
Genetic Counseling, Personalized Medicine, and Precision Health
Erica Ramos
Index
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Genes & Development

Edited By T. Grodzicker, Cold Spring Harbor Laboratory Press

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© 2019 • ISSN 0890-9369; Volume 33 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2019, 24 semimonthly issues
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Description

Genes & Development publishes high-quality research papers of broad general interest and biological significance in the areas of molecular biology, molecular genetics, and related fields. G&D publishes two research formats; Research papers and short Research Communications, in addition to Review Articles and Perspectives. G&D consistently ranks in the top 10 among primary research journals in all fields of science.
This journal is published in association with The Genetics Society.
Subscription to the print journal includes full access to the online edition (online-only subscriptions are available upon request).

 
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Genome Research

Edited By Hillary Sussman, Cold Spring Harbor Laboratory Press; Aravinda Chakravarti, Johns Hopkins School of Medicine; Richard Gibbs, Baylor College of Medicine; Eric Green, Bethesda, MD; Richard Myers, HudsonAlpha Institute for Biotechnology; William Pavan, Derwood, MD

Online Features: Internet edition – Genome Research Online at Stanford University Libraries' HighWire Press; Electronic supplementary material – auxiliary data available only via the journal's online edition

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© 2019 • ISSN: 1088-9051; Volume 29 includes full online access
FREE TRIAL ACCESS offer for libraries! Contact cironek@cshl.edu.
January - December 2019, 12 monthly issues
Journal Subscription

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Description

In August 1995, Cold Spring Harbor Laboratory Press began publication of a new, monthly, international, peer-reviewed journal, Genome Research. The journal focuses on genome studies in all species, and presents research that provides or aids in genome-based analyses of biological processes. The journal represents a nexus point where genomic information, applications, and technology come together with biological information to create a more global understanding of all biological systems.

Among the research considered by the journal are novel reports on gene discovery, comparative genome analyses, evolution studies, informatics, genome structure and function, technological innovations and applications, statistical and mathematical methods, cutting-edge genetic and physical mapping and DNA sequencing, and other reports that present data where sequence information is used to address biological concerns.

New data in these areas are published as research papers in the form of articles and letters, or methods and resource reports that provide novel information on methodologies or resources that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides review articles, perspectives, and Insight/Outlook articles, which presents commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.

Subscription to the print journal includes full access to the online edition (online-only subscriptions are not available).

 
 

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