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Ras and Cancer in the 21st Century

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell Biology

Edited by Linda Van Aelst, Cold Spring Harbor Laboratory; Julian Downward, The Francis Crick Institute; Frank McCormick, University of California, San Francisco

Due May 2018 • 250 pages (approx.), illustrated, index
Hardcover • $135 94.50 (click here to price in UK Pounds)
ISBN  978-1-621822-21-9
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  •     Description    
  •     Contents    


Ras proteins are critical molecular switches in signaling mechanisms that control cell behavior and are frequently mutated in cancer. This volume examines the functions of Ras, how its activation leads to tumorigenesis, and ways in which excessive Ras signaling may be targeted therapeutically.


The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants
Jillian A. Parker and Carla Mattos
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
Andrew M. Waters and Channing J. Der
Ras and MAPK
Neal Rosen
P13K: A Crucial Piece in the RAS Signaling Puzzle
Agata Adelajda Krygowska and Esther Castellano
From Ras to Rap and Back, A Journey of 35 Years
Johannes L. Bos
Targeting Ras with Macromolecules
Dehua Pei, Kuangyu Chen, and Hui Liao
Post-Translational Modifications of RAS Proteins
Ian Ahearn, Mo Zhou, and Mark Philips
Targeting the MAPK Pathway in RAS Mutant Cancers
Sarah G. Hymowitz and Shiva Malek
Ras-Mediated Activation of the Raf Family Kinases
Elizabeth M. Terrell and Deborah K. Morrison
GAP Structure
Klaus Scheffzek
Synthetic Lethal Vulnerabilities in KRAS-mutant Cancers
Andrew J. Aguirre and William C. Hahn
Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras
Anica Wandler and Kevin Shannon
The Interdependent Activation of SOS and Ras
Pradeep Bandaru, Yasushi Kondo, and John Kuriyan
Genetically Engineered Mouse Models of K-RAS Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets
Matthias Drosten, Carmen Guerra, and Mariano Barbacid
Kras in Organoids
Derek Cheng and David Tuveson
Ras and the Plasma Membrane: A Complicated Relationship
Yong Zhou, Priyanka Prakash, Alemayehu A. Gorfe, and John F. Hancock
Kras and Tumor Immunity: Friend or Foe?
Jane Cullis, Shipra Das, and Dafna Bar-Sagi
Efforts to Develop KRAS Inhibitors
Matthew Holderfield
Nf1 Therapy
Karen Cichowski
MRAS: A Close but Understudied Member of the Ras family
Lucy C. Young and Pablo Rodriguez-Viciana