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Prostate Cancer


Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseDiseasesCancer Biology

Edited by Michael M. Shen, Columbia University Medical Center; Mark A. Rubin, Cornell University

Due November 2018 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621821-64-9
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  •     Description    
  •     Contents    

Description

Prostate cancer is the most commonly diagnosed cancer in men and causes thousands of deaths annually. Many prostate tumors are slow growing and localized to the prostate, whereas others are more aggressive and spread to other areas of the body (e.g., bones). Work to better understand prostate cancer will lead to improved treatment options and more precise care for patients with this disease.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the recent progress that has been made in understanding the pathogenesis and treatment of prostate cancer. The contributors review the normal development, anatomy, and histology of the prostate; the genetic, lifestyle, and dietary factors associated with prostate cancer risk; and the alterations in the genome, epigenetic landscape, transcriptional networks, and metabolic and signaling pathways that drive oncogenesis. The role of the tumor microenvironment in prostate cancer pathogenesis is covered, as are the molecular mechanisms of metastasis. The authors also discuss how mouse models and patient-derived tissues can be used to study aspects of the disease and accelerate the development of appropriate therapies.

Other topics include methods for diagnosing and monitoring prostate cancer, such as biomarker (e.g., serum PSA) testing, histopathological grading, and anatomical and molecular imaging techniques, as well as treatment options that are currently available and under development. Strategies that may prevent prostate cancer altogether (e.g., chemoprevention) are also described. This volume is therefore a vital reference for all cancer biologists and clinician-scientists concerned with defeating this disease.

Contents

Preliminary
Foreword
Charles Sawyers
1. Introduction
Michael Shen and Mark Rubin
2. Anatomy and Histology of the Human and Murine Prostate
Michael Ittmann
3. Prostate Organogenesis
Jeffrey C. Francis and Amanda Swain
4. The Epidemiology of Prostate Cancer
Claire Pernar, Ericka Ebot, Kathryn M. Wilson, and Lorelei A. Mucci
5. Prostate Cancer Germline Variations and Implications for Screening and Treatment
Alexander Dias, Zsofia Kote-Jarai, Christos Mikropoulos, and Ros Eeles
6. Prostate Cancer Disparities by Race and Ethnicity: From Nucleotide to Neighborhood
Timothy R. Rebbeck
7. Stem Cells and Cancer Stem Cells
Michael Shen
8. Pre-neoplastic Lesions
Angelo DeMarzo
9. Histopathology of Prostate Cancer
Peter A. Humphrey
10. Genomics
Mark Rubin
11. Transcriptional Regulation in Prostate Cancer
David P. Labbé and Myles Brown
12. Epigenetics
Srinivasan Yegnasubramanian
13. Androgen signaling in prostate cancer
Charles Dai, Hannelore Heemers, and Nima Sharifi
14. New Opportunities for Targeting the Androgen Receptor in Prostate Cancer
Margaret M. Centenera, Luke A. Selth, Esmaeil Ebrahimie, Lisa M. Butler, and Wayne D. Tilley
15. DNA Damage Response in Prostate Cancer
Matthew J. Schiewer and Karen E. Knudsen
16. Chemoprevention in Prostate Cancer: Current Perspective and Future Directions
J. Ricardo Rivero Jr., Ian M. Thompson Jr., Michael A. Liss, and Dharam Kaushik
17. Cellular Constituents of the Prostate Stroma: Key Contributors to Prostate Cancer Progression and Therapy Resistance
Christine Levesque and Peter S. Nelson
18. Genetically Engineered Mouse Models of Prostate Cancer in the Post-Genomic Era
Juan M. Arriaga and Cory Abate-Shen
19. Pre-Clinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids and Other Explant Models
Gail P. Risbridger, Roxanne Toivanen, and Renea A. Taylor
20. Preclinical and Co-Clinical Studies in Prostate Cancer
Ming Chen and Pier Paolo Pandolfi
21.The Genomics of Prostate Cancer: An Historic Perspective
Mark A. Rubin and Francesca Demichelis
22. Metabolic Vulnerabilities of Prostate Cancer: Diagnostic and Therapeutic Opportunities
Giorgia Zadra and Massimo Loda
23. Metastases in Prostate Cancer
Federico La Manna, Sofia Karkampouna, Eugenio Zoni, Marta De Menna, Janine Hensel, George N. Thalmann, and Marianna Kruithof-de Julio
24. Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models and Therapy
Loredana Puca, Panagiotis J. Vlachosterogios, and Himisha Beltran
25. Molecular biomarkers in the clinical management of prostate cancer
Aaron M. Udager and Scott A. Tomlins
26. Anatomic and Molecular Imaging in Prostate Cancer
Eric T. Miller, Amirali Salmalsi, and Robert E. Reiter
27. Immunotherapy
Charles Drake
28. Treatment of Advanced Prostate Cancer; A Review of Current Therapies and Future Promise
Semini Sumanasuriya and Johann De Bono
Index