Contents

Preliminary

Preface

Bioelectronic Medicine: Principles and Mechanisms

Kevin J. Tracey

Restoring Movement in Paralyzed Limbs: Future Directions and Challenges

Chad E. Bouton

Recording and Decoding of Peripheral Neural Signals Related to Changes in Physiological Parameters and Biomarkers of Disease

Theodoros P. Zanos

Closed-Loop Neuromodulation in Physiological and Translational Research

Stavros Zanos

The Use of Bioelectronics in the Gastrointestinal Tract

Larry Miller, Aydin Farajidavar, and Anil Vegesna

Opportunities for Bioelectronics Medicine in the Setting of Acute Life-Threatening Deterioration and Emergencies

Lance Becker

Electromagnetic Regulation of Cell Activity

Sarah A. Stanley and Jeffrey M. Friedman

Empirically Based Guidelines for Selecting Vagus Nerve Stimulation Parameters in Epilepsy and Heart Failure

Eric D. Musselman, Nicole A. Pelot, and Warren M. Grill

Harnessing the Cholinergic Inflammatory Reflex with Neurostimulation

Mike Faltys and Yaakov Levine

The Vagus Nerve as a Sensor-Actuator Network: A Computer Science Perspective

Christopher I. Connolly, Matthew Crossley, Patrick D. Lincoln, Carolyn Talcott, and Maneesh Yadav

TBD

Peder Olofsson and Michael Eberhardson

Vagus Nerve Stimulation at the Interface of Brain–Gut Interactions

Bruno Bonaz, Valérie Sinniger, and Sonia Pellissier

Technobiology's Enabler: The Magnetoelectric Nanoparticle

Sakhrat Khizroev

Enteric Neuromodulation for the Gut and Beyond

Yogi A. Patel and Prankaj J. Pasricha

Alternative Methods for Noninvasive Neuromodulation of the Peripheral Nervous System Using Ultrasound

Christopher Puleo and Victoria Cotero

Bioelectronic Medicine—Ethical Concerns

Samuel Packer, Nicholas Mercado, and Anita Haridat

Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies

Jonathan B. Rothbard, Michael P. Kurnellas, Shalina S. Ousman, Sara Brownell, Jesse J. Rothbard, and Lawrence Steinman

Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury

Tsuyoshi Inoue, Shinji Tanaka, Diane L. Rosin, and Mark D. Okusa

Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light

Haifeng Ye and Martin Fussenegger

Microscale and Nanoscale Electrophotonic Diagnostic Devices

Kaiyu Fu, Wei Xu, Jenny Hu, Arielle Lopez, and Paul W. Bohn

Diabetes Technology: Monitoring, Analytics, and Optimal Control

Boris Kovatchev

Optogenetic Control of the Peripheral Nervous System

Rui B. Chang

Electrical Impedance Methods in Neuromuscular Assessment: An Overview

Seward Rutkove and Benjamin Sanchez

Index