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Cytokines: From Basic Mechanisms of Cellular Control to New Therapeutics

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell Biology

Edited by Warren J. Leonard, Bethesda MD; Robert D. Schreiber, St. Louis MO

© 2018 • 325 pages (approx.), illustrated, index
Hardcover • $135 108.00
ISBN  978-1-621821-25-0
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Cytokines (e.g., interleukins and interferons) are small signaling proteins that are essential for communication between cells. They are important regulators of the immune system, helping to control lymphocyte development and function, orchestrate inflammation, and defeat microbial and viral invaders. But they also play important roles in the nervous system, embryonic development, and diseases such as cancer.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the spectrum of cytokines that are produced and their roles in normal physiology and disease. The contributors examine the numerous cytokines and their cognate receptors, the downstream signaling mechanisms (e.g., JAK-STAT pathways) that mediate the effects of cytokines on cells, and the regulators that keep them in check (e.g., long noncoding RNAs and the SOCS and IRF protein families). These molecular interactions are discussed in the context of their physiological effects; the roles of cytokines in the development and activities of the immune system are emphasized.

The authors also explore how the actions of cytokines may be modulated for treating patients with autoimmune disorders, immunodeficiency, infections, allergies, and cancer. Thus, this volume is an indispensable reference not only for cell biologists and immunologists but for all who are interested in targeting cytokine signaling for therapeutic purposes.


Structure of Cytokines
J. Fernando Bazan
Alex Kallies and Ajithkumar Vasanthakumar
GC Family Cytokines
Warren J. Leonard
Role of the β Common (βc) Family of Cytokines in Health and Disease
Timothy R. Hercus, Winnie L.T. Kan, Sophie E. Broughton, Denis Tvorogov, Hayley S. Ramshaw, Jarrod J. Sandow, Tracy L. Nero, Urmi Dhagat, Emma J. Thompson, Karen S. Cheung Tung Shing, Duncan R. McKenzie, Nicholas J. Wilson, Catherine M. Owczarek, Gino Vairo, Andrew D. Nash, Vinay Tergaonkar, Timothy Hughes, Paul G. Ekert, Michael S. Samuel, Claudine S. Bonder, Michele A. Grimbaldeston, Michael W. Parker, and Angel F. Lopez
IL-6 Family Cytokines
Stefan Rose-John
IL-17 Family Cytokines Show Some Skin
Leticia Monin and Sarah L. Gaffen
IL-12 and IL-23 and Their Conflicting Roles in Cancer
Juming Yan, Mark J. Smyth, and Michele W.L. Teng
Targeting IL-10 Family Cytokines for the Treatment of Human Diseases
Xiaoting Wang, Kit Wong, Wenjun Ouyang, and Sascha Ruiz
The Interferon Class of Cytokines and the IRF Transcription Factor Family
Hideo Negishi, Tadatsugu Tanigushi, and Hideyuki Yanai
The Tumor Necrosis Factor (TNF) Family: Family Conventions and Private Idiosyncrasies
David Wallach
Responses to Cytokines and Interferons that Depend of JAKs and STATs
George R. Stark, HyeonJoo Cheon, and Yuxin Wang
Inflammasome-Dependent Cytokines at the Crossroads of Health and Autoinflammatory Disease
Hanne Van Gorp, Nina Van Opdenbosch, and Mohamed Lamkanfi
Negative Regulation of Cytokine Signaling in Immunity
Akihiko Yoshimura, Mitsuhiro Kanamori, and Shunsuke Chikuma
Cytokines and Long Noncoding RNAs
Susan Carpenter and Katherine A. Fitzgerald
T Helper Cell Differentiation and Plasticity
Jinfang Zhu
Cytokine Signaling in the Development and Homeostasis of Regulatory T Cells
Kevin H. Toomer and Thomas R. Malek
Development, Diversity, and Function of Dendritic Cells in Mouse and Human
David A. Anderson III, Kenneth M. Murphy, and Carlos G. Briseño
Cytokines, Transcription Factors, and the Initiation of T Cell Development
Hiroyuki Hosokawa and Ellen V. Rothenberg
IL-6 Immunotherapy
Toshio Tanaka, Masashi Narazaki, and Tadamitsu Kishimoto
Cytokines and Viral Infection
Rafi Ahmed
Cancer Inflammation and Cytokines
Maria Rosaria Galdiero, Gianni Marone, and Alberto Mantovani
IFNs and Cancer Immunoediting and Natural Immunity to Cancer
Robert D. Schreiber
Cytokines in Cancer Immunotherapy
Thomas A. Waldmann
Cytokines and Breg Cells and Therapeutic Potential
Thomas F. Tedder
The Future of the Cytokine Discipline
Joost J. Oppenheim
Cytokines and Innate Lymphoid Cells
Hergen Spits