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Addiction, Second Edition

Subject Area(s):  Cognition and BehaviorHuman Biology and DiseaseNeurobiology

Edited by R. Christopher Pierce, University of Pennsylvania School of Medicine; Ellen M. Unterwald, Lewis Katz School of Medicine, Temple University; Paul J. Kenny, Icahn School of Medicine at Mt. Sinai

Due September 2020 • 300 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-50-6
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  •     Contents    


Addiction to psychoactive drugs found in cigarettes, alcoholic drinks, and opioid analgesics is a severe problem for society. Events associated with addiction—drug abuse, dependence, withdrawal, and relapse—involve complex neurobiological changes in the brain. To develop effective long-term treatment strategies for drug addiction, a more complete understanding of these brain changes is needed.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive update on our understanding of the biological basis of and treatment strategies for addiction to psychoactive drugs, with an emphasis on opioids. Contributors examine the molecular targets of alcohol, cannabinoids, nicotine, and opioids, the resulting changes to the neurocircuitry, and various genetic, environmental, developmental, and behavioral factors that influence the progression from abuse to addiction and susceptibility to relapse. Advances in animal models of addictive behavior and single-cell strategies to dissect neural circuits are also described.

In addition, the authors review compounds currently used or under development to treat drug addiction, their pharmacological mechanisms, and challenges related to preclinical testing in animal models. This volume is an indispensable reference for all neuroscientists and those who are interested in understanding and reducing the public health burden of drug addiction.


Addiction pharmacotherapies
S.E. Swinford-Jackson, R. Christopher Pierce, Charles P. O'Brien, Paul J. Kenny, and Louk J.M.J. Vanderschuren
Animal Studies of Addictive Behavior
Louk J.M.J. Vandershuren and Serge H. Ahmed
Multi-symptomatic animal model
David Belin and Véronique Deroche-Gamonet
Neural Substrates and Circuits of Drug Addiction
Matthew W. Feltenstein, Ronald E. See, and Rita A. Fuchs
Developments from Bulk Optogenetics to Single-Cell Strategies to Dissect the Neural Circuits that Underlie Aberrant Motivational States
Jose Rodriguez-Romaguera, Vijay M.K. Namboodiri, Marcus L. Basiri, Alice M. Stamatakis, and Garret D. Stuber
Structural Plasticity
Sam A. Golden and Scott J. Russo
Aversive Responses
William A. Carlezon, Jr.
Synaptic Plasticity
Christian Lüscher
Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission
William J. Wright and Yan Dong
Ian Maze
GLP-1 and Addiction
Heath D. Schmidt and Paul J. Kenny
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area
Camilla Bellone, Michael Loureiro, and Christian Lüscher
Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons
Marie A. Doyle and Michelle S. Mazei-Robison
Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction
Jasper A. Heinsbroek, Taco J. De Vries, and Jamie Peters
Medications Development for Treatment of Opioid Use Disorder
E.A. Townsend, S.S. Negus, and Matthew L. Banks
Genetic Vulnerability of Opioid Addiction
Brian Reed and Mary Jeanne Kreek
Sabita Roy
M. Pravetoni
Consequences of Parental Opioid Exposer on Neurophysiology, Behavior, and Health in the Next Generations
Fair Vassoler and Mathiew Wimmer
Mechanisms of Nicotine Addiction
Marina R. Picciotto and Paul J. Kenny
Adolescent Exposure
Huibert D. Mansvelder
Theresa Patten, John A. Dani, and Mariella De Biasi
Translational Research in Nicotine Addiction
Miranda L. Fisher, James Pauly, Brett Froeliger, and Jill R. Turner
The Role of the Central Amygdala in Alcohol Dependence
Marisa Roberto, Dean Kirson, and Sophia Khom
Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis
Andrew E. Weller, Richard C. Crist, Benjamin C. Reiner, Glenn A. Doyle, and Wade H. Berrettini
Growth Factors and Alcohol Use Disorder
Mirit Liran, Nofar Rahamin, Dorit Ron, and Segev Barak
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and Addiction
Kate Z. Peters, Erik B. Oleson, and Joseph F. Cheer
Impairment of Synaptic Plasticity by Cannabis, δ-9THC, and Synthetic Cannabinoids
Alexander F. Hoffman, Eun-Kyung Hwang, and Carl R. Lupica