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Influenza: The Cutting Edge

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and Disease

Edited by Gabriele Neumann, University of Wisconsin – Madison; Yoshihiro Kawaoka, University of Wisconsin – Madison

Due December 2020 • 450 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-07-0
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  •     Description    
  •     Contents    


Influenza is a serious infectious disease caused by different influenza viruses that can mutate to form new strains. Some of these strains give rise to epidemics or pandemics, infecting millions worldwide each year. Because evolutionary changes in these viruses are difficult to predict and our understanding of their pathogenic effects is incomplete, the development of effective vaccines and therapeutics for influenza remains challenging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews cutting-edge research on the viruses that cause influenza, the molecular mechanisms of infection, the epidemiology of these viruses in humans and animals, and current strategies for designing vaccines and antivirals. Contributors discuss all aspects of the molecular virology of influenza—the viral and host factors involved in the attachment and entry into host cells, the transcription and replication of viral genomes, and virus assembly and budding. The various factors and conditions that determine susceptibility to influenza infection and disease severity are also covered, as is our current understanding of the ecology and evolution of influenza viruses, the various subtypes, and their transmission and epidemiology in humans, birds, swine, bats, and other animals.

In addition, the authors examine the human immune response to influenza infection, insights gained from animal models, and technological advances in the design and delivery of vaccines and antivirals. This volume is therefore an essential reference for all virologists, clinical and laboratory investigators, and physicians interested in reducing the global public health burden of influenza.


Structure and Function of the Influenza Virus Transcription and Replication Machinery
Ervin Fodor and Aartjan J.W. te Velthuis
Influenza Polymerase Structure
Stephen Cusack
Influenza HA structures and receptor specificity
John Skehel
Influenza Hemagglutinin Structures and Antibody Recognition
Nicholas C. Wu and Ian A. Wilson
The Structure, Function, and Pathobiology of the Influenza Virus Ion Channels
Robert A. Lamb
Accessory genes

Paul Digard
Influenza virus packaging
Yoshi Kawaoka and Takeshi Noda
Cell factors that determine influenza host range
Wendy Barclay
The Two Sides of the Same Coin—Influenza Virus and Intracellular Signal Transduction
Stephan Ludwig, Eike R. Hrincius, and Yvonne Boergeling
Experimental Approaches to Identify Host Factors Important for Influenza Virus
Grace A. Schaack and Andrew Mehle
Synthetic Virology: Building Viruses to Better Understand Them
Benjamin R. tenOever
Quantifying Between-Host Transmission in Influenza Virus Infections
Katherine E.E. Johnson and Elodie Ghedin
The Ecology and Evolution of Influenza Viruses
Michelle Wille and Edward C. Holmes
Influenza phylogeny
Gavin Smith
Reverse Genetics—Historical Perspective of Influenza Reverse Genetics
Gabriele Neumann
The 1918 Influenza Pandemic and Its Legacy
Jeffery K. Taubenberger and David M. Morens
Influenza pathogenesis in humans
Peter Openshaw
Molecular epidemiology of influenza viruses
Dave Wentworth, Jackie M. Katz, Rebecca J. Kondor, and Xiyan Xu
Human Susceptibility to Influenza Infection and Severe Disease
Robert C. Mettelman and Paul G. Thomas
Influenza in children
Jennifer Nayak, Gregory Hoy, and Aubree Gordon
Influenza in High Risk Hosts—Lessons Learned from Animal Models
Rebekah Honce, Nicholas Wohlgemuth, Victoria A. Meliopoulos, Kirsty R. Short, and Stacey Schultz-Cherry
Human influenza epidemiology in Southeast Asia
Benjamin Cowling
Avian Influenza Infection in Humans
Shu Yuelong
Human influenza surveillance
Andy Pekosz
Emerging influenza viruses
George Gao
H5 influenza viruses in Egypt
Richard Webby
H7N9 viruses
Hualan Chen
H9 Influenza Viruses: An Emerging Challenge
Silvia Carnaccini and Daniel R. Perez
Pathobiological Origins and Evolutionary History of Highly Pathogenic Avian Influenza Viruses
Dong-Hun Lee, Miria Ferreira Criado, and David E. Swayne
Swine Influenza A Viruses and the Tangled Relationship with Humans
Tavis K. Anderson, Jennifer Chang, Zebulun W. Arendsee, Divya Venkatesh, Carine K. Souza, J. Brian Kimble, Nicola S. Lewis, C. Todd Davis, and Amy L. Vincent
Equine influenza
Tom Chambers
Canine and Feline Influenza
Brian R. Wasik, Ian E.H. Voorhees, and Colin R. Parrish
Bat-Borne Influenza A Viruses: An Awakening
Kevin Ciminski and Martin Schwemmle
Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model
Jessica A. Belser, Joanna A. Pulit-Penaloza, and Taronna R. Maines
Original Antigenic Sin: How Original, How Sinful?
Jonathan W. Yewdell and Jefferson J.S. Santos
Influenza Vaccines Delivered in Early Childhood Could Turn Antigenic Sin into Antigenic Blessings
Michael Worobey, Stanley Plotkin, and Scott E. Hensley
Characterization of influenza virus-specific antibodies
James Crowe
Antibody repertoire in humans
Patrick Wilson & Linda Yu-Ling Lan
Immunity to Influenza Infection in Humans
David J. Topham, Marta Lopez-DeDiego, Aitor Nogales, Mark S. Sangster, and Andrea Sant
Immune responses to influenza virus infections
Rafi Ahmed
Innate immune responses to influenza virus infections
Adolfo Garcia-Sastre
Systems biology analysis of immune responses
Bali Pulendran
Influenza vaccines
Barney Graham & Masaru Kanekiyo
Influenza vaccine effectiveness
Edward Belongia and Huong McLean
Cold-adapted live influenza vaccines
Kanta Subbarao
Human influenza challenge
Matthew Memoli
Influenza Therapeutics in Clinical Practice—Challenges and Recent Advances
John H Beigel and Frederick G. Hayden
Polymerase inhibitors
Emi Takashita
Neuraminidase inhibitors
Larisa Gubareva