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Signaling by Receptor Tyrosine Kinases


Subject Area(s):  Developmental BiologyCell BiologyMolecular Biology

Edited by Joseph Schlessinger, Yale University School of Medicine; Mark A. Lemmon, University of Pennsylvania, Perelman School of Medicine

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© 2014 • 478 pp., illus. (86 4C, 15 B&W), index
Hardcover • $135 94.50
ISBN  978-1-936113-33-0
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Description

Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF), and molecules involved in neuronal guidance. Ligand binding stimulates the tyrosine kinase activity of the receptors, leading to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation, differentiation, and numerous other biological processes.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the mechanisms underlying receptor tyrosine kinase signaling, including ligand processing, receptor dimerization, receptor trafficking, and the roles of adapters. The contributors also survey the specific functions of the different subfamilies of receptors and examine their many roles in development and normal physiology.

In addition, the authors review the important roles of these proteins in insulin resistance and cancer. This volume is thus a vital reference for cell and developmental biologists as well as those working on cancer biology, diabetes, and obesity.

Contents

Preface
SECTION I. INTRODUCTION: HISTORICAL PERSPECTIVES
Receptor Tyrosine Kinases: Legacy of the First Two Decades
Joseph Schlessinger
The Genesis of Tyrosine Phosphorylation
Tony Hunter
SECTION II. PRINCIPLES OF CELLULAR SIGNALING BY RTKs
Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling
Melany J. Wagner, Melissa M. Stacey, Bernard A. Liu, and Tony Pawson
Receptor Tyrosine Kinases in the Nucleus
Graham Carpenter and Hong-Jun Liao
Biological Function of Nuclear Receptor Tyrosine Kinase Action
Sungmin Song, Kenneth M. Rosen, and Gabriel Corfas
Endocytosis of Receptor Tyrosine Kinases
Lai Kuan Goh and Alexander Sorkin
Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases
Marta Miaczynska
Regulation of Receptor Tyrosine Kinase Ligand Processing
Colin Adrain and Matthew Freeman
Complexity of Receptor Tyrosine Kinase Signal Processing
Natalia Volinsky and Boris N. Kholodenko
SECTION III. SPECIFIC MOLECULAR FEATURES AND MECHANISMS OF KEY RTK FAMILIES
The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase
Stevan R. Hubbard
The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases
Mark A. Lemmon, Joseph Schlessinger, and Kathryn M. Ferguson
The Spatiotemporal Organization of ErbB Receptors: Insights from Microscopy
Christopher C. Valley, Keith A. Lidke, and Diane S. Lidke
Structure-Function Relationships of ErbB RTKs in the Plasma Membrane of Living Cells
Donna J. Arndt-Jovin, Michelle G. Botelho, and Thomas M. Jovin
Structural and Functional Properties of Platelet-Derived Growth Factor and Stem Cell Factor Receptors
Carl-Henrik Heldin and Johan Lennartsson
VEGFR and Type-V RTK Activation and Signaling
Masabumi Shibuya
Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology
Artur A. Belov and Moosa Mohammadi
The Role of MuSK in Synapse Formation and Neuromuscular Disease
Steven J. Burden, Norihiro Yumoto, and Wei Zhang
Structure and Physiology of the RET Receptor Tyrosine Kinase
Carlos F. Ibáñez
Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling
William A. Barton, Annamarie C. Dalton, Tom C.M. Seegar, Juha P. Himanen, and Dimitar B. Nikolov
Eph Receptor Signaling and Ephrins
Erika M. Lisabeth, Giulia Falivelli, and Elena B. Pasquale
The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction
Jennifer Green, Roel Nusse, and Renée van Amerongen
SECTION IV. RTKs IN DEVELOPMENT
Receptor Tyrosine Kinases in Drosophila Development
Richelle Sopko and Norbert Perrimon
Biology of the TAM Receptors
Greg Lemke
SECTION V. RTKs IN DISEASE AND MEDICINE
Receptor Tyrosine Kinase-Mediated Angiogenesis
Michael Jeltsch, Veli-Matti Leppänen, Pipsa Saharinen, and Kari Alitalo
Insulin Receptor Signaling in Normal and Insulin-Resistant States
Jérémie Boucher, André Kleinridders, and C. Ronald Kahn
MET: A Critical Player in Tumorigenesis and Therapeutic Target
Carrie R. Graveel, David Tolbert, and George F. Vande Woude
Central Role of RET in Thyroid Cancer
Massimo Santoro and Francesca Carlomagno
Index