Contents

Symposium Participants

Foreword

 

Development and Antigen Receptor Gene Assembly

TET Proteins and 5-Methylcytosine Oxidation in the Immune System

Ageliki Tsagaratou and Anjana Rao

Control of Antigen Receptor Diversity through Spatial Regulation of V(D)J Recombination

Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, and Meinrad Busslinger

Establishment and Maintenance of B Cell Identity

Rudolf Grosschedl

Transcriptional Establishment of Cell-Type Identity: Dynamics and Causal Mechanisms of T-Cell Lineage Commitment

Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, and Mary A. Yui

The Epigenetics of Early Lymphocyte Development

C. Murre

 

Gene Regulation

Regnase-1, a Ribonuclease Involved in the Regulation of Immune Responses

Shizuo Akira

Toward an Understanding of the Gene-Specific and Global Logic of Inducible Gene Transcription

Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, and Ann-Jay Tong

Tolerization of Inflammatory Gene Expression

John J. Seeley and Sankar Ghosh

The ‘Histone Mimicry’ by Pathogens

Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, and Alexander Tarakhovsky

 

Development and Function of Myeloid Subsets

Myb-Independent Macrophages: A Family of Cells That Develops with Their Tissue of Residence and Is Involved in Its Homeostasis

Elisa Gomez Perdiguero and Frederic Geissmann

The Molecular Choreography of IRF4 and IRF8 with Immune System Partners

Harinder Singh, Elke Glasmacher, Abraham B. Chang, and Bryan Vander Lugt

The IRF Family Transcription Factors at the Interface of Innate and Adaptive Immune Responses

Hiroaki Ikushima, Hideo Negishi, and Tadatsugu Taniguchi

 

T-Cell Differentiation and Function

IL-1 b Strikingly Enhances Antigen-Driven CD4 and CD8 T-Cell Responses

S.Z. Ben-Sasson, K. Wang, J. Cohen, and W.E. Paul

A Modified Model of T-Cell Differentiation Based on mTOR Activity and Metabolism

Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, and Adam T. Waickman

Novel Tools to Dissect the Dynamic Regulation of TCR Signaling by the Kinase Csk and the Phosphatase CD45

Ying Xim Tan, Julie Zikherman, and Arthur Weiss

 

NK Cells and Innate Lymphoid Cells

Dissection of Signaling in Inflammation: Three Novel Inflammatory Regulators

Thorsten Berger, Mary E. Saunders, and Tak W. Mak

Tissue-Resident Natural Killer Cells

Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, and Zhigang Tian

 

Microbial Immunity

Immunology Taught by Human Genetics

Jean-Laurent Casanova, Laurent Abel, and Lluis Quintana-Murci

Systems Approach to Understand the Immune Response in Tuberculosis: An Iterative Process between Mouse Models and Human Disease

Anne O’Garra

The Zebrafish Guide to Tuberculosis Immunity and Treatment

Lalita Ramakrishnan

Microbiota: Host Interactions in Mucosal Homeostasis and Systemic Autoimmunity

Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, and Dan R. Littman

The Promised Land of Human Immunology

Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, and Mark M. Davis

 

Tolerance, TREGS and Inflammasome

Transcriptional Control of Regulatory T-Cell Differentiation

Joris van der Veeken, Aaron Arvey, and Alexander Rudensky

miR-181 and Metabolic Regulation in the Immune System

Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, and Richard A. Flavell

Encoding Immunological Memory in the Initiation of B-Cell Receptor Signaling

Susan K. Pierce and Wanli Liu

 

Tumor Immunology and Genome Stability

Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function

Koichi Araki, Ben Youngblood, and Rafi Ahmed

Immune Surveillance of Unhealthy Cells by Natural Killer Cells

Alexandre Iannello and David H. Raulet

Studying Epstein-Barr Virus Pathologies and Immune Surveillance by Reconstructing EBV Infection in Mice

Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, and Klaus Rajewsky

 

Closing Lecture

Pathogen-Sensing, Regulatory T Cells, and Responsiveness-Tuning Collectively Regulate Foreign- and Self-Antigen Mediated T-Cell Responses

William E. Paul, Joshua D. Milner, and Zvi Grossman

 

Author Index

 

Subject Index