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Prion Biology and Diseases, Second Edition

(Cold Spring Harbor Monograph Series 41)

Book Series:  Cold Spring Harbor Monograph Series
Subject Area(s):  Cell BiologyProteins and ProteomicsHuman Biology and DiseaseBiochemistryNeurobiology

Edited by Stanley B. Prusiner, University of California, San Francisco

© 2004 • 1,050 pp., illus., color plates, glossary, appendix, index
Hardcover • $147 29.40
ISBN  978-087969693-1
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  •     Description    
  •     Contents    
  •     Reviews    

Description

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize–winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

Contents

PRION BIOLOGY
Chapter 1: An Introduction to Prion Biology and Diseases
S.B. Prusiner
Chapter 2: Development of the Prion Concept
S.B. Prusiner
Chapter 3: Bioassays of Prions
S.B. Prusiner, J. Safar, and S.J. DeArmond
Chapter 4: Transmission and Replication of Prions
S.B. Prusiner, M.R. Scott, S.J. DeArmond, and G. Carlson
Chapter 5: Structural Studies of Prion Proteins
C. Govaerts, H. Wille, S.B. Prusiner, and F.E. Cohen
Chapter 6: Doppel, a New PrP–like Mammalian Protein
D. Westaway, L.E. Hood, and S.B. Prusiner
FUNGAL PRIONS
Chapter 7: Prions of Yeast and Filamentous Fungi: [URE3], [PSI+], [PIN+], and [Het–s]
R.B. Wickner, S.W. Liebman, and S.J. Saupe
TRANSGENETICS AND CELL BIOLOGY OF PRIONS
Chapter 8: Knockouts, Knockins, Transgenics, and Transplants in Prion Research
E. Flechsig, J.C. Manson, R. Barron, A. Aguzzi, and C. Weissmann
Chapter 9: Transgenetic Investigations of the Species Barrier and Prion Strains
M. Scott, D. Peretz, R.M. Ridley, H.F. Baker, S.J. DeArmond, and S.B. Prusiner
Chapter 10: Cell Biology of Prions
D.A. Harris, P.J. Peters, A. Taraboulos, V. Lingappa, S.J. DeArmond, and S.B. Prusiner
PRION DISEASES IN ANIMALS
Chapter 11: Scrapie, Chronic Wasting Disease, and Transmissible Mink Encephalopathy
S.B. Prusiner, E. Williams, J.–L. Laplanche, and M. Shinagawa
Chapter 12: Bovine Spongiform Encephalopathy and Related Diseases
G.A.H. Wells and J.W. Wilesmith
HUMAN PRION DISEASES
Chapter 13: Infectious and Sporadic Prion Diseases
R.G. Will, M.P. Alpers, D. Dormont, and L.B. Schonberger
Chapter 14: Inherited Prion Diseases
Q. Kong, W.K. Surewicz, R.B. Petersen, W. Zou, S.G. Chen, P. Gambetti, P. Parchi, S. Capellari, L. Goldfarb, P. Montagna, E. Lugaresi, P. Piccardo, and B. Ghetti
Chapter 15: Neuropathology of Prion Diseases
S.J. DeArmond, J.W. Ironside, E. Bouzamondo–Bernstein, D. Peretz, and J.R. Fraser
METHODOLOGY, BIOSAFETY, AND THERAPEUTICS
Chapter 16: Some Strategies and Methods for the Study of Prions
S.B. Prusiner, G. Legname, S.J. DeArmond, F.E. Cohen, J. Safar, D. Riesner, and K. Kaneko
Chapter 17: Biosafety Issues in Prion Diseases
H. Baron, J. Safar, D. Groth, S.J. DeArmond, and S.B. Prusiner
Chapter 18: Therapeutic Approaches to Prion Diseases
S.B. Prusiner, B.C.H. May, and F.E. Cohen
Glossary
Appendix
Index

Reviews

review:  “Because of the increasing importance of prions to public health, and the burgeoning rate of discovery in prion biology, this is a timely occasion for a second edition of the book Prion Biology and Diseases. As with the first edition (published in 1999), the extensively revised and updated second edition is edited and substantially written by Stanley Prusiner.

The book is comprehensive, authoritative, accessible and, for the most part, exciting to read. It will serve admirably as a standard of the new science of “prionology” for scientists, physicians and students.”
      —Nature Cell Biology

review:  “The Editor hoped this book would stimulate and tempt young investigators to prion research. It certainly informs the novice that there is more to prions than mad cows and cannibals! And for the established researcher? This book should make a useful reference text as data from an extensive number of studies are contained within the same volume.”
      —Microbiology Today