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Addiction, Second Edition


Subject Area(s):  Cognition and BehaviorHuman Biology and DiseaseNeurobiology

Edited by R. Christopher Pierce, University of Pennsylvania School of Medicine; Ellen M. Unterwald, Lewis Katz School of Medicine, Temple University; Paul J. Kenny, Icahn School of Medicine at Mt. Sinai

Due August 2020 • 300 pages (approx.), illustrated, index
Hardcover • $135
ISBN  978-1-621823-50-6

  •     Description    
  •     Contents    

Description

Addiction to cigarettes, alcohol and drugs such as opioids is a severe problem for society. The new addition of this book examines recent progress in our understanding of the biological basis of addiction and recent progress in treatment strategies.

Contents

Preliminary
INTRODUCTION
Addiction pharmacotherapies
S.E. Swinford-Jackson, R. Christopher Pierce, Charles P. O'Brien, Paul J. Kenny, and Louk J.M.J. Vanderschuren
SECTION 1: METHODS AND MODELS
Animal Studies of Addictive Behavior
Louk J.M.J. Vandershuren and Serge H. Ahmed
Multi-symptomatic animal model
David Belin and Véronique Deroche-Gamonet
Neural Substrates and Circuits of Drug Addiction
Matthew W. Feltenstein, Ronald E. See, and Rita A. Fuchs
Developments from Bulk Optogenetics to Single-Cell Strategies to Dissect the Neural Circuits that Underlie Aberrant Motivational States
Jose Rodriguez-Romaguera, Vijay M.K. Namboodiri, Marcus L. Basiri, Alice M. Stamatakis, and Garret D. Stuber
SECTION 2: PSYCHOSTIMULANTS
Structural Plasticity
Sam A. Golden and Scott J. Russo
Aversive Responses
William A. Carlezon, Jr.
Synaptic Plasticity
Christian Lüscher
Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission
William J. Wright and Yan Dong
Epigenetics
Ian Maze
GLP-1 and Addiction
Heath D. Schmidt and Paul J. Kenny
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area
Camilla Bellone, Michael Loureiro, and Christian Lüscher
SECTION 3: OPIATES
Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons
Marie A. Doyle and Michelle S. Mazei-Robison
Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction
Jasper A. Heinsbroek, Taco J. De Vries, and Jamie Peters
Medications Development for Treatment of Opioid Use Disorder
E.A. Townsend, S.S. Negus, and Matthew L. Banks
Genetic Vulnerability of Opioid Addiction
Brian Reed and Mary Jeanne Kreek
Microbiome
Sabita Roy
Vaccines
M. Pravetoni
Consequences of Parental Opioid Exposer on Neurophysiology, Behavior, and Health in the Next Generations
Fair Vassoler and Mathiew Wimmer
SECTION 4: NICOTINE
Mechanisms of Nicotine Addiction
Marina R. Picciotto and Paul J. Kenny
Adolescent Exposure
Huibert D. Mansvelder
Habenula
Theresa Patten, John A. Dani, and Mariella De Biasi
Translational Research in Nicotine Addiction
Miranda L. Fisher, James Pauly, Brett Froeliger, and Jill R. Turner
SECTION 5: ALCOHOL
The Role of the Central Amygdala in Alcohol Dependence
Marisa Roberto, Dean Kirson, and Sophia Khom
Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis
Andrew E. Weller, Richard C. Crist, Benjamin C. Reiner, Glenn A. Doyle, and Wade H. Berrettini
Growth Factors and Alcohol Use Disorder
Mirit Liran, Nofar Rahamin, Dorit Ron, and Segev Barak
SECTION 6: CANNABINOIDS
A Brain on Cannabinoids: The Role of Dopamine Release in Reward Seeking and Addiction
Kate Z. Peters, Erik B. Oleson, and Joseph F. Cheer
Impairment of Synaptic Plasticity by Cannabis, δ-9THC, and Synthetic Cannabinoids
Alexander F. Hoffman, Eun-Kyung Hwang, and Carl R. Lupica
Index