Protein Synthesis and Translational Control

Click to Enlarge				Protein Synthesis and Translational Control Subject Area(s): Proteins and Proteomics; Molecular Biology; Genetics; Biochemistry Edited by John W.B. Hershey, University of California, Davis; Nahum Sonenberg, McGill University; Michael B. Mathews, New Jersey Medical School, University of Medicine and Dentistry of New Jersey Download Free Excerpts from Protein Synthesis and Translational Control: Download Preface and Contents Download Chapter 1 Download Index

				© 2012 • 352 pp., illustrations, index Hardcover • ~~$135~~ 67.50 ISBN 978-1-936113-46-0 You save: 50% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and a group of genetic disorders termed "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of all aspects of protein synthesis and its control. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of translational machinery where this takes place. They review the targets of translational control (e.g., initiation factors, mRNAs, and ribosomes) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as cancer biologists and all those investigating human diseases associated with translation dysfunction. Contents Preface Principles of Translational Control: An Overview John W.B. Hershey, Nahum Sonenberg, and Michael B. Mathews The Structure and Function of the Eukaryotic Ribosome Daniel N. Wilson and Jamie H. Doudna Cate The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges Alan G. Hinnebusch and Jon R. Lorsch The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes Thomas E. Dever and Rachel Green Single-Molecule Analysis of Translational Dynamics Alexey Petrov, Jin Chen, Seán O’Leary, Albert Tsai, and Joseph D. Puglisi The Current Status of Vertebrate Cellular mRNA IRESs Richard J. Jackson From Cis-Regulatory Elements to Complex RNPs and Back Fátima Gebauer, Thomas Preiss, and Matthias W. Hentze Regulation of mRNATranslation by Signaling Pathways Philippe P. Roux and Ivan Topisirovic Protein Secretion and the Endoplasmic Reticulum Adam M. Benham New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response Graham D. Pavitt and David Ron P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation Carolyn J. Decker and Roy Parker mRNA Localization and Translational Control in Drosophila Oogenesis Paul Lasko Toward a Genome-Wide Landscape of Translational Control Ola Larsson, Bin Tian, and Nahum Sonenberg Imaging Translation in Single Cells Using Fluorescent Microscopy Jeffrey A. Chao, Young J. Yoon, and Robert H. Singer A Molecular Link between miRISCs and Deadenylases Provides New Insight into the Mechanism of Gene Silencing by MicroRNAs Joerg E. Braun, Eric Huntzinger, and Elisa Izaurralde Translational Control in Cancer Etiology Davide Ruggero Cytoplasmic RNA-Binding Proteins and the Control of Complex Brain Function Jennifer C. Darnell and Joel D. Richter Tinkering with Translation: Protein Synthesis in Virus-Infected Cells Derek Walsh, Michael B. Mathews, and Ian Mohr Emerging Therapeutics Targeting mRNATranslation Abba Malina, John R. Mills, and Jerry Pelletier Index

Protein Synthesis and Translational Control

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