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Metastasis: Mechanism to Therapy

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Jeffrey W. Pollard, The University of Edinburgh; Yibin Kang, Princeton University

Due December 2019 • 275 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-24-7
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  •     Contents    


Metastasis is a critical stage in cancer progression in which cells from the original tumor spread to other locations in the body and seed secondary tumors. This volume examines the molecular mechanisms underlying metastasis, describing how malignant cells change morphology, migrate out of the primary site, and establish new tumors at distant locations. It also discusses ongoing research into how this may be prevented.


Cancer Cell Dormancy in Metastasis
Matthew A. Summers, Michelle M. McDonald, and Peter I. Croucher
Pre-Metastatic Niche
Yoshiro Maru
Impact of Immunometabolism on Cancer Metastasis: A Focus on T Cells and Macrophages
Nina C. Flerin, Ria Pinioti, Alessio Menga, Alessandra Castegna, and Massimiliano Mazzone
The Immune Microenvironment and Cancer Metastasis
Asmaa El-Kenawi, Kay Hanggi, and Brian Ruffell
Normal Aging and its Role in Cancer Metastasis
Mitchell Fane and Ashani T. Weeraratna
Brain Metastasis Organotropism
Arseniy E. Yuzhalin and Dihua Yu
Bone Trophism in Cancer Metastases
Hai Wang, Weijie Zhang, Igor Bado, and Xiang H.-F. Zhang
Myeloid Cells in Metastasis
Agnieszka Swierczak and Jeffrey W. Pollard
Liver Trophism in Cancer—The Hepatic Metastatic Niche
Ainhoa Mielgo and Michael C. Schmid
Extracellular Vesicles and Metastasis
Shizhen Emily Wang
Clinical Perspectives in Brain Metastasis
Krutika Deshpande, Ian Buchanan, Vahan Martirosian, and Josh Neman
New Approaches on Cancer Immunotherapy
Jong-Ho Cha, Li-Chuan Chan, Min Sup Song, and Mien-Chie Hung
The Etiology and Impact of Muscle Wasting in Metastatic Cancer
Anup K. Biswas and Swarnali Acharyya
The Different Facets of Liquid Biopsy: A Kaleidoscopic View
Zahra Eslami-S, Luis Enrique Cortés-Hernéndez, Laure Cayrefourca, and Catherine Alix-Panabières
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
Toni Celià-Terrassa and Mohit Kumar Jolly
Zebrafish In Vivo Models of Cancer and Metastasis
Katy R. Astell and Dirk Sieger
Cellular Plasticity during Metastasis: New Insights Provided by Intravital Microscopy
Andreia S. Margarido, Laura Bornes, Claire Vennin, and Jacco van Rheenen