The p53 Protein: From Cell Regulation to Cancer

Click to Enlarge				The p53 Protein: From Cell Regulation to Cancer Book Series: A Cold Spring Harbor Perspectives in Medicine Collection Subject Area(s): Cell Biology; Cancer Biology Edited by Guillermina Lozano, The University of Texas M.D. Anderson Cancer Center; Arnold J. Levine, Institute for Advanced Study *Download a Free Excerpt from The p53 Protein: From Cell Regulation to Cancer:* Preface Index

				© 2016 • 504 pages, illustrated (69 color, 19 B&W), index Hardcover • ~~$135~~ 94.50 ISBN 978-1-621821-33-5 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a “guardian of the genome,” protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in—and sometimes even promotes—human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease. Contents Preface I. THE STRUCTURE AND FUNCTIONS OF THE p53 PROTEIN The Paradox of p53: What, How, and Why? Yael Aylon and Moshe Oren Structural Evolution and Dynamics of the p53 Proteins Giovanni Chillemi, Sebastian Kehrloesser, Francesca Bernassola, Alessandro Desideri, Volker Dötsch, Arnold J. Levine, and Gerry Melino p53 Isoforms: Key Regulators of the Cell Fate Decision Sebastien M. Joruiz and Jean-Christophe Bourdon The Transactivation Domains of the p53 Protein Nitin Raj and Laura D. Attardi Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53 Neil T. Pfister and Carol Prives Tumor-Suppressor Functions of the TP53 Pathway Brandon J. Aubrey, Andreas Strasser, and Gemma L. Kelly II. THE REGULATION OF CELLULAR FUNCTIONS BY THE p53 PROTEIN p53 in the DNA-Damage-Repair Process Ashley B. Williams and Björn Schumacher Genome Stability Requires p53 Christine M. Eischen The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression Jiandong Chen Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres Caitlin M. Roake and Steven E. Artandi The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence Crystal A. Tonnessen-Murray, Guillermina Lozano, and James G. Jackson Autophagy and p53 Eileen White The Evolution of the Ribosomal Protein–MDM2&ndashp53 Pathway Chad Deisenroth, Derek A. Franklin, and Yangping Zhang Regulation of Cellular Metabolism and Hypoxia by p53 Timothy J. Humpton and Karen H. Vousden The Role of the p53 Protein in Stem-Cell Biology and Epigenetic Regulation Arnold J. Levine, Anna M. Puzio-Kuter, Chang S. Chan, and Pierre Hainaut p53 and the Carcinogenicity of Chronic Inflammation Andrei V Gudkov and Elena A. Komarova III. p53 MUTATIONS IN HUMAN CANCERS Somatic TP53 Mutations in the Era of Genome Sequencing Pierre Hainaut and Gerd P. Pfeifer The Inherited p53 Mutation in the Brazilian Population Maria Isabel Achatz and Gerard P. Zambetti Oncogenic Mutant p53 Gain of Function Nourishes the Vicious Cycle of Tumor Development and Cancer Stem-Cell Formation Yoav Shetzer, Alina Molchadsky, and Varda Rotter Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End Amanda R. Wasylishen and Guillermina Lozano Inherited TP53 Mutations and the Li–Fraumeni Syndrome Tanya Guha and David Malkin IV. THE p53 PATHWAY IN HUMAN CANCERS—CLINICAL MANIFESTATIONS The Role of MDM2 Amplification and Overexpression in Tumorigenesis Jonathan D. Oliner, Anne Y. Saiki, and Sean Caenepeel MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond Jean-Christophe Marine and Aart G. Jochemsen Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges Shaomeng Wang, Yujun Zhao, Angelo Aguilar, Denzil Bernard, and Chao-Yie Yang TP53 Mutations in Breast and Ovarian Cancer Laxmi Silwal-Pandit, Anita Langerød, and Anne-lise Børresen-Dale p53 as an Effector or Inhibitor of Therapy Response Julien Ablain, Brigitte Poirot, Cécile Esnault, Jacqueline Lehmann-Che, and Hugues de Thé p53 and Medulloblastoma Vijay Ramaswamy, Carolina Nör, and Michael D. Taylor TP53 Mutations in Hypodiploid Acute Lymphoblastic Leukemia Evan Q. Comeaux and Charles G. Mullighan Clinical Outcomes of TP53 Mutations in Cancers Ana I. Robles, Jin Jen, and Curtis C. Harris Genetic Modifiers of the p53 Pathway Subhasree Basu and Maureen E. Murphy Exploiting the p53 Pathway for Therapy Chit Fang Cheok and David Philip Lane Index

The p53 Protein: From Cell Regulation to Cancer

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