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Cell Survival and Cell Death, Second Edition


Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Kim Newton, Genentech; James M. Murphy, Walter and Eliza Hall Institute of Medical Research; Edward A. Miao, University of North Carolina at Chapel Hill

Due November 2019 • 300 pages (approx.), illustrated, index
Paperback • $135 108.00
ISBN  978-1-621823-55-1
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  •     Contents    

Description

Cell death plays a critical role in development, normal physiology, and many diseases, including cancer. This new edition on the subject provides a state-of-the-art summary of our understanding of the signaling mechanisms that regulate cell survival and cell death, along with the molecular mechanisms underlying the various different death processes seen in cells.

Contents

Preliminary
BAX, BAK, and BOK; A Coming of Age for the BCL-2 Family Effector Proteins
Tudor Moldoveanu and Peter E. Czabotar
BH3 Mimetics: Targeting Pro-Survival Bcl2 Family Members for the Treatment of Cancer
David Huang and Wayne Fairbrother
Mechanisms of Caspase Activation
Marion Macfarlane
Cracking the Cell Death Code
Carla V. Rothlin and Sourav Ghosh
Phagocyte responses to cell death in flies
Andrew J. Davidson and Will Wood
Multi-tasking Kinase RIPK1 Regulates Cell Death and Inflammation
Kim Newton
The Killer Pseudokinase MLKL
James M. Murphy
Targeting Death Receptors in Cancer and Inflammation
Henning Walczak
Recent Insights on Inflammasomes, Gasderin Pores, and Pyroptosis
Xia, Louis Robert Hollingsworth IV, and Hao Wu
A20 at the Crossroads of Cell Death, Inflammation, and Autoimmunity
Arne Martens and Geert van Loo
Regulation of Cell Death and Immunity by XIAP
Philipp J. Jost and Domagoj Vucic
Cell Death and Neurodegeneration
Benjamin J. Andreone, Martin Larhammar, and Joseph W. Lewcock
Evolution of the Cell Death Machinery
Kay Hofmann
Programmed Cell Death in the Evolutionary Race Against Bacterial Virulence Factors
Carolyn A. Lacey and Edward A. Miao
How Viral Pathogens Subvert the Cell Death Machinery
Bill Kaiser
Cell Cycle Crosstalk with Caspases and Their Substrates
Patrick Connolly, Irmina García-Carpio, and Andreas Villunger
The Hypersensitive Response Cell Death in Plant Immunity
Eugenia Pitsii, Ujjal J. Phukan, and Núria S. Coll
Dysregulation of Cell Death in Chronic Human Inflammation
Yue Li, Christoph Klein, and Daniel Kotlarz
Neutrophil Extracellular Traps in Host Defense
Sabrina Sofia Burgener and Kate Schroder
Index