Signaling by Receptor Tyrosine Kinases

Subject Area(s): Developmental Biology; Cell Biology; Molecular Biology

Edited by Joseph Schlessinger, Yale University School of Medicine; Mark A. Lemmon, University of Pennsylvania, Perelman School of Medicine

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© 2014 • 478 pp., illus. (86 4C, 15 B&W), index
Hardcover • ~~$135~~ 94.50
ISBN 978-1-936113-33-0
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Description
Contents

Description

Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor (EGF) and fibroblast growth factor (FGF), and molecules involved in neuronal guidance. Ligand binding stimulates the tyrosine kinase activity of the receptors, leading to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation, differentiation, and numerous other biological processes.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the mechanisms underlying receptor tyrosine kinase signaling, including ligand processing, receptor dimerization, receptor trafficking, and the roles of adapters. The contributors also survey the specific functions of the different subfamilies of receptors and examine their many roles in development and normal physiology.

In addition, the authors review the important roles of these proteins in insulin resistance and cancer. This volume is thus a vital reference for cell and developmental biologists as well as those working on cancer biology, diabetes, and obesity.

Preface
SECTION I. INTRODUCTION: HISTORICAL PERSPECTIVES
Receptor Tyrosine Kinases: Legacy of the First Two Decades: Joseph Schlessinger
The Genesis of Tyrosine Phosphorylation: Tony Hunter
SECTION II. PRINCIPLES OF CELLULAR SIGNALING BY RTKs
Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling: Melany J. Wagner, Melissa M. Stacey, Bernard A. Liu, and Tony Pawson
Receptor Tyrosine Kinases in the Nucleus: Graham Carpenter and Hong-Jun Liao
Biological Function of Nuclear Receptor Tyrosine Kinase Action: Sungmin Song, Kenneth M. Rosen, and Gabriel Corfas
Endocytosis of Receptor Tyrosine Kinases: Lai Kuan Goh and Alexander Sorkin
Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases: Marta Miaczynska
Regulation of Receptor Tyrosine Kinase Ligand Processing: Colin Adrain and Matthew Freeman
Complexity of Receptor Tyrosine Kinase Signal Processing: Natalia Volinsky and Boris N. Kholodenko
SECTION III. SPECIFIC MOLECULAR FEATURES AND MECHANISMS OF KEY RTK FAMILIES
The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase: Stevan R. Hubbard
The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases: Mark A. Lemmon, Joseph Schlessinger, and Kathryn M. Ferguson
The Spatiotemporal Organization of ErbB Receptors: Insights from Microscopy: Christopher C. Valley, Keith A. Lidke, and Diane S. Lidke
Structure-Function Relationships of ErbB RTKs in the Plasma Membrane of Living Cells: Donna J. Arndt-Jovin, Michelle G. Botelho, and Thomas M. Jovin
Structural and Functional Properties of Platelet-Derived Growth Factor and Stem Cell Factor Receptors: Carl-Henrik Heldin and Johan Lennartsson
VEGFR and Type-V RTK Activation and Signaling: Masabumi Shibuya
Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology: Artur A. Belov and Moosa Mohammadi
The Role of MuSK in Synapse Formation and Neuromuscular Disease: Steven J. Burden, Norihiro Yumoto, and Wei Zhang
Structure and Physiology of the RET Receptor Tyrosine Kinase: Carlos F. Ibáñez
Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling: William A. Barton, Annamarie C. Dalton, Tom C.M. Seegar, Juha P. Himanen, and Dimitar B. Nikolov
Eph Receptor Signaling and Ephrins: Erika M. Lisabeth, Giulia Falivelli, and Elena B. Pasquale
The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction: Jennifer Green, Roel Nusse, and Renée van Amerongen
SECTION IV. RTKs IN DEVELOPMENT
Receptor Tyrosine Kinases in Drosophila Development: Richelle Sopko and Norbert Perrimon
Biology of the TAM Receptors: Greg Lemke
SECTION V. RTKs IN DISEASE AND MEDICINE
Receptor Tyrosine Kinase-Mediated Angiogenesis: Michael Jeltsch, Veli-Matti Leppänen, Pipsa Saharinen, and Kari Alitalo
Insulin Receptor Signaling in Normal and Insulin-Resistant States: Jérémie Boucher, André Kleinridders, and C. Ronald Kahn
MET: A Critical Player in Tumorigenesis and Therapeutic Target: Carrie R. Graveel, David Tolbert, and George F. Vande Woude
Central Role of RET in Thyroid Cancer: Massimo Santoro and Francesca Carlomagno
Index