The Cytoskeleton

Subject Area(s): Microscopy and Imaging; Cell Biology

Edited by Thomas D. Pollard, Department of Molecular, Cellular, and Developmental Biology, Yale University; Robert D. Goldman, Chairman, Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University

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Preface
Chapter 1: Overview of the Cytoskeleton from an Evolutionary Perspective
Index

© 2017 • 391 pages, illustrated (100 color and 22 B&W), index
Hardcover • ~~$135~~ 108.00
ISBN 978-1-621820-16-1
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Description
Contents

Description

The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins.

This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.

Preface
Overview of the Cytoskeleton from an Evolutionary Perspective: Thomas D. Pollard and Robert D. Goldman
PART 1. CYTOSKELETAL AND MOTILITY PROTEINS
Actin and Actin-Binding Proteins: Thomas D. Pollard
Microtubules and Microtubule-Associated Proteins: Holly V. Goodson and Erin M. Jonasson
Intermediate Filaments: Structure and Assembly: Harald Herrmann and Ueli Aebi
Motor Proteins: H. Lee Sweeney and Erika L.F. Holzbaur
Cytoskeleton Integrators: The Spectrin Superfamily: Ronald K.H. Liem
PART 2. CYTOSKELETON IN CELL AND TISSUE ARCHITECTURE
Actin-Based Adhesion Modules Mediate Cell Interactions with the Extracellular Matrix and Neighboring Cells: Alexia I. Bachir, Alan Rick Horwitz, W. James Nelson, and Julie M. Bianchini
The Centrosome, a Multitalented Renaissance Organelle: Anastassiia Vertii, Heidi Hehnly, and Stephen Doxsey
Types I and II Keratin Intermediate Filaments: Justin T. Jacob, Pierre A. Coulombe, Raymond Kwan, and M. Bishr Omary
Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin: Elly M. Hol and Yassemi Capetanaki
Neurofilaments and Neurofilament Proteins in Health and Disease: Aidong Yuan, Mala V. Rao, Veeranna, and Ralph A. Nixon
Intermediate Filaments and the Plasma Membrane: Jonathan C.R. Jones, Chen Yuan Kam, Robert M. Harmon, Alexandra V. Woychek, Susan B. Hopkinson, and Kathleen J. Green
The Nucleoskeleton: Stephen A. Adam
Mechanical Properties of the Cytoskeleton and Cells: Adrian F. Pegoraro, Paul Janmey, and David A. Weitz
PART 3. INTRACELLULAR TRANSPORT
Microtubule-Based Transport and the Distribution, Tethering, and Organization of Organelles: Kari Barlan and Vladimir I. Gelfand
Intraflagellar Transport and Ciliary Dynamics: Hiroaki Ishikawa and Wallace F. Marshall
Intracellular Motility of Intermediate Filaments: Rudolf E. Leube, Marcin Moch, and Reinhard Windoffer
Myosin-Driven Intracellular Transport: Margaret A. Titus
PART 4. CELLULAR MOTILITY
The Actin Cytoskeleton and Actin-Based Motility: Tatyana Svitkina
Muscle Contraction: H. Lee Sweeney and David W. Hammers
Ciliary Motility: Regulation of Axonemal Dynein Motors: Rasagnya Viswanadha, Winfield S. Sale, and Mary E. Porter
Intermediate Filaments and the Regulation of Cell Motility during Regeneration and Wound Healing: Fang Cheng and John E. Eriksson
PART 5. CELL DIVISION
Mitosis: J. Richard Mcintosh
Cytokinesis in Metazoa and Fungi: Michael Glotzer
Index

The Cytoskeleton

Description

Contents