The Biology of the TGF-β Family

Book Series: A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s): Developmental Biology; Cell Biology; Immunology and Vaccines

Edited by Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo

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Preface
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
Index

© 2017 • 1164 pages, illustrated (149 color and 8 B&W), index
Hardcover • ~~$135~~ 108.00
ISBN 978-1-621820-36-9
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Description
Contents
Reviews

Description

The transforming growth factor β (TGF-β) family is a large group of structurally related proteins that drive developmental programs and control cell behavior. The TGF-β family members exert their effects by binding to receptors on the cell surface, activating intracellular signaling pathways that modulate gene expression programs that control normal cell physiology, immune responses, and a variety of developmental processes. TGF-β signaling is also important in conditions such as cancer, skeletal disorders, and cardiovascular diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive view of the different members of the TGF-β family, the signaling pathways they control, and how they influence development, normal physiology, and disease. The contributors describe the various TGF-β family ligands, including activins and bone morphogenetic proteins (BMPs), the structures and functions of the type I and type II receptors, and how ligand-receptor binding is regulated. Both Smad and non-Smad signaling pathways are discussed, as is cross talk between TGF-β and other signaling pathways (e.g., Wnt). Individual chapters are devoted to the roles of TGF-β signaling in specific biological processes, including cell proliferation, mesenchymal differentiation, branching morphogenesis, stem cell biology, immunity, vascular function, reproduction, and neurobiology. The roles of TGF-β signaling in cancer, fibrosis, skeletal diseases, and other conditions, as well as prospects for therapeutics, are also covered.

The authors also review TGF-β signaling in model organisms (e.g., C. elegans and Drosophila), as well as the discovery of TGF-β and early research in the field. This volume is therefore a comprehensive reference on the biology of the TGF-β family, and it will be valuable for not only cell and developmental biologists but all who wish to learn about this important field of research.

Preface
The Discovery and Early Days of TGF-β: A Historical Perspective: Harold L. Moses, Anita B. Roberts, and Rik Derynck
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology: Masato Morikawa, Rik Derynck, and Kohei Miyazono
Activins and Inhibins: Roles in Development, Physiology, and Disease: Maria Namwanje and Chester W. Brown
Bone Morphogenetic Proteins: Takenobu Katagiri and Tetsuro Watabe
Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins: Ian B. Robertson and Daniel B. Rifkin
Agonists and Antagonists of TGF-β Family Ligands: Chenbei Chang
Signaling Receptors for TGF-β Family Members: Carl-Henrik Heldin and Aristidis Moustakas
Structural Biology and Evolution of theTGF-β Family: Andrew P. Hinck, Thomas D. Mueller, and Timothy A. Springer
TGF-β Signaling from Receptors to Smads: Akiko Hata and Ye-Guang Chen
Transcriptional Control by the SMADs: Caroline S. Hill
Posttranslational Regulation of Smads: Pinglong Xu, Xia Lin, and Xin-Hua Feng
Regulation of TGF-β Family Signaling by Inhibitory Smads: Keiji Miyazawa and Kohei Miyazono
Structural Basis of Intracellular TGF-β Signaling: Receptors and Smads: Apirat Chaikuad and Alex N. Bullock
Non-Smad Signaling Pathways of the TGF-β Family: Ying E. Zhang
Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways: Kunxin Luo
TGF-β Family Signaling in the Control of Cell Proliferation and Survival: Yun Zhang, Peter B. Alexander, and Xiao-Fan Wang
TGF-β Family Signaling in Drosophila: Ambuj Upadhyay, Lindsay Moss-Taylor, Myung-Jun Kim, Arpan C. Ghosh, and Michael B. O’Connor
The TGF-β Family in Caenorhabditis elegans: Cathy Savage-Dunn and Richard W. Padgett
TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation: Alan C. Mullen and Jeffrey L. Wrana
TGF-β Family Signaling in Early Vertebrate Development: Joseph Zinski, Benjamin Tajer, and Mary C. Mullins
TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition: Kaoru Kahata, Mahsa Shahidi Dadras, and Aristidis Moustakas
TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis: Kaoru Kahata, Varun Maturi, and Aristidis Moustakas
TGF-β Family Signaling in Mesenchymal Differentiation: Ingo Grafe, Stefanie Alexander, Jonathan R. Peterson, Taylor Nicholas Snider, Benjamin Levi, Brendan Lee, and Yuji Mishina
TGF-β Family Signaling in Control of Cardiovascular Function: Marie-José Goumans and Peter ten Dijke
Bone Morphogenetic Proteins in Vascular Homeostasis and Disease: Marie-José Goumans, An Zwijsen, Peter ten Dijke, and Sabine Bailly
Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling Molecules: Kazuhito Naka and Atsushi Hirao
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection: Shomyseh Sanjabi, Soyoung A. Oh, and Ming O. Li
TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function: Emily A. Meyers and John A. Kessler
The TGF-β Family in the Reproductive Tract: Diana Monsivais, Martin M. Matzuk, and Stephanie A. Pangas
TGF-β Family Signaling in Connective Tissue and Skeletal Diseases: Elena Gallo MacFarlane, Julia Haupt, Harry C. Dietz, and Eileen M. Shore
TGF-β1 Signaling and Tissue Fibrosis: Kevin K. Kim, Dean Sheppard, and Harold A. Chapman
TGF-β Family Signaling in Tumor Suppression and Cancer Progression: Joan Seoane and Roger R. Gomis
TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment: Michael W. Pickup, Philip Owens, and Harold L. Moses
Targeting TGF-β Signaling for Therapeutic Gain: Rosemary J. Akhurst
Bone Morphogenetic Protein–Based Therapeutic Approaches: Jonathan W. Lowery and Vicki Rosen
Index

Reviews

“This volume contains 35 review articles that cover the biology of various TGF-β family ligands, including activins and bone morphogenic proteins (BMPs). This is a state-of-the-art collection with highly signiﬁcant contributions. The articles provide comprehensive information to most...of the topics addressed.”
—The Quarterly Review of Biology

The Biology of the TGF-β Family

Description

Contents

Reviews