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The Endoplasmic Reticulum, Second Edition

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell BiologyMolecular BiologyBiochemistry

Edited by Susan Ferro-Novick, UC San Diego, School of Medicine; Tom Rapoport, Harvard Medical School; Randy Schekman, University of California at Berkeley

Download a Free Excerpt from The Endoplasmic Reticulum, Second Edition:

Sorting and Export of Proteins at the Endoplasmic Reticulum

© 2023 • 368 pages, illustrated (89 color and 1 B&W), index
Hardcover •
ISBN  978-1-621824-37-4

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  •     Description    
  •     Contents    


The endoplasmic reticulum (ER) is a network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis.

Written and edited by experts in the field, this new collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive update on advances in our understanding of the structure and multiple functions of the ER. The contributors examine how proteins enter the ER, the biogenesis of membrane proteins, and the role of the ER in protein sorting and quality control. In addition, they discuss how lipids are synthesized and transported to and from the ER.

The volume reviews the architecture of the ER and the ways in which it interacts with other organelles. The consequences for metabolic health and neurodegeneration are also considered. It is thus an essential reference for cell biologists, as well as physiologists and pathologists interested in understanding the role of the ER in disease.


Mechanism of Protein Translocation by the Sec61 Translocon Complex
Samuel Itskanov and Eunyong Park
The Biogenesis of Multipass Membrane Proteins
Luka Smalinskaitė and Ramanujan S. Hegde
A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum
Alina Guna, Masami Hazu, Giovani Pinton Tomaleri, and Rebecca M. Voorhees
The Endoplasmic Reticulum and the Fidelity of Nascent Protein Localization
Michael J. McKenna and Sichen Shao
Endoplasmic Reticulum—Associated Protein Degradation
Logesvaran Krshnan, Michael L. van de Weijer, and Pedro Carvalho
The Role of the Rhomboid Superfamily in ER Protein Quality Control: From Mechanisms and Functions to Diseases
Satarupa Bhaduri, Nicola A. Scott, and Sonya E. Neal
Post-Translational Regulation of HMG CoA Reductase
Youngah Jo and Russell A. DeBose-Boyd
Evolutionary Aspects of the Unfolded Protein Response
Kazutoshi Mori
AMPylation and Endoplasmic Reticulum Protein Folding Homeostasi
Luke A. Perera and David Ron
Regulation and Functions of the ER-Associated Nrf1 Transcription Facto
Gary Ruvkun and Nicolas Lehrbach
Sorting and Export of Proteins at the Endoplasmic Reticulum
Ishier Raote, Sonashree Saxena, and Vivek Malhotra
Cargo Receptor-Mediated ER Export in Lipoprotein Secretion and Lipid Homeostasis
Xiao Wang and Xiao-Wei Chen
ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophag
Haruka Chino and Noboru Mizushima
Lipid Transport from Endoplasmic Reticulum to Autophagic Membranes
Takuo Osawa, Kazuaki Matoba, and Nobuo N. Noda
Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration
Andrés Guillén-Samander and Pietro De Camilli
Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum
Robert V. Farese, Jr. and Tobias C. Walther
Cholesterol Transport to the Endoplasmic Reticulum
John P. Kennelly and Peter Tontonoz
Structural Diversity within the Endoplasmic Reticulum—From the Microscale to the Nanoscal
Christopher J. Obara, Andrew S. Moore, and Jennifer Lippincott-Schwartz
Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease
Ana Paula Arruda and Güneş Parlakgül
Structure and Function of the Nuclear Pore Complex
Stefan Petrovic, George W. Mobbs, Christopher J. Bley, Si Nie, Alina Patke, and André Hoelz