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Lung Cancer: Disease Biology and Its Potential for Clinical Translation

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Cell BiologyCancer Biology

Edited by Christine M. Lovly; David P. Carbone; John D. Minna

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Due January 2022 • 250 pages (approx.), illustrated, index
Hardcover • $135 94.50
ISBN  978-1-621823-73-5
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  •     Description    
  •     Contents    


Lung cancer affects millions of people worldwide and is the leading cause of cancer death in both men and women in the United States. There are two main types of lung cancer: small-cell and non-small-cell. These cancers grow differently, are treated differently, and lead to different outcomes. Recent advances in the clinic and laboratory are leading to significant enhancements in patient care.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the progress that has been made in understanding the molecular pathogenesis of lung cancer and how this information is leading to improved detection and treatment strategies. The contributors review the genomic, transcriptomic, epigenomic, and proteomic changes associated with lung carcinogenesis, the histologic and metabolic features of different types of lung cancer, and the roles of the immune microenvironment and cancer stem cells in tumor maintenance and metastasis. The large databases of demographic and clinical information, high-throughput platforms that generate molecular data, advanced computational methods (e.g., radiomics and artificial intelligence), and preclinical models that facilitate advances in basic and translational research are also covered.

In addition, the authors discuss progress on risk prediction, diagnostic strategies (e.g., liquid biopsy), and therapies for both small-cell and non-small-cell lung cancer. This volume is therefore a vital reference for all cancer biologists and clinician-scientists devoted to reducing the public health burden of this disease.


David Carbone, Christine Lovly, and John Minna
Early Diagnosis and Screening for Lung Cancer
Humam Kadara, Lihn M. Tran, Anil Vachani, Bin Liu, Xianghong J. Zhou, Ansam Sinjab, Shuo Li, Steven M. Dubinett, and Kostyantyn Krysan
Molecular Pathology of Lung Cancer
James Saller and Theresa A. Boyle
Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development
Anna Arnal Estape, Giorgia Foggetti, Jacqueline Starrett, Don Nguyen, and Katerina Politi
Targeting Epigenetics in Lung Cancer
Yvonne L. Chao and Chad V. Pecot
Lung Cancer Metabolism
Gina M. DeNicola and David B. Shackelford
Tumor Immunology and Immunotherapy of Non-Small Cell Lung Cancer
Tina Cascone, Jared Fradette, Monika Pradhan, and Don L. Gibbons
Stem Cell Biology and Lineage Plasticity
David Carbone and Carla Kim
Advances in SCLC Translational Research
Benjamin J. Drapkin and Charles M. Rudin
Application of Radiomics and AI for Lung Cancer Precision Medicine
Ilke Tunali, Robert J. Gillies, and Matthew B. Schabath
Radiation Therapy in Non-Small Cell Lung Cancer
Michael Dohopolski, Sujana Gottumukkala, Daniel Gomez, and Puneeth Iyengar
Lung Cancer Computational Biology and Resources
Yang Xie
Concluding Remarks
David Carbone, Christine Lovly, and John Minna