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Cell-Cell Junctions, Second Edition

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Cell Biology

Edited by Carien M. Niessen, University of Cologne; Alpha S. Yap, Institute for Molecular Bioscience, University of Queensland

Download a Free Excerpt from Cell-Cell Junctions, Second Edition:

Cell–Cell Junctions Organize Structural and Signaling Networks

© 2017 • 374 pages, illustrated (60 color and 2 B&W), index
Hardcover •
ISBN  978-1-621821-51-9

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  •     Description    
  •     Contents    
  •     Reviews    


Neighboring cells are linked to each other by multimolecular complexes such as adherens junctions, desmosomes, and gap junctions. These complexes help maintain tissue integrity, act as barriers to permeability, reinforce cell polarity, and allow cells to communicate with each other.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of the organization, regulation, and dynamics of cell–cell junctions and the roles they play in morphogenesis, tissue homeostasis, and disease. The contributors examine the assembly and structure of different cell–cell adhesion systems, the plasticity of cell–cell junctions (e.g., during cell migration), and how the junctions act as hubs to sense and transduce various mechanical and chemical signals.

The authors also discuss the roles of cell–cell junctions in specific developmental and physiological processes, such as hearing, skeletal myogenesis, and neural circuit assembly, as well as in diseases such as cancer. This volume is therefore an indispensable reference for cell and developmental biologists, as well as anyone interested in understanding the roles of these complexes in human health and disease.


New concepts in the cell biology of junctions
Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions
René Marc Mège and Noboru Ishiyama
Signaling at Cell-Cell Junctions: Protein Interactions Building Control and Networks
Vania Braga
Cell Junctions in Hippo Signaling
Ruçhan Karaman and Georg Halder
Mechanosensing and Mechanotransduction at Cell-Cell Junctions
Alpha S. Yap, Kinga Duszyc, and Virgile Viasnoff
Adherens Junctions on the Move—Membrane Trafficking of E-Cadherin
Lena Brüser and Sven Bogden
Desmosomes and Intermediate Filaments: Their Consequences for Mechanics
Mechthild Hatzfeld, René Keil, and Thomas M. Magin
Guidance Receptors and Cell-Cell Junctions
Ian V. Beamish, Lindsay Hinck, and Timothy E. Kennedy
The biology of cell-cell junctions
Cell-Cell Junctions and Morphogenesis
Carl-Phillip Heisenberg
Cell-Cell Junctions Organize Structural and Signaling Networks To Regulate Epithelial Tissue Homeostasis
Miguel A. Garcia, W. James Nelson, and Natalie Chavez
Tuning Collective Cell Migration by Cell-Cell Junction Regulation
Peter Friedl and Roberto Mayor
Junctions and Polarity in Stratified Epithelia
Carien M. Niessen
Cell-Cell Contact and Receptor Tyrosine Kinase Signaling
Christine Chiasson-MacKenzie and Andrea I. McClatchey
Beyond Cell-Cell Adhesion: Sensational Cadherins for Hearing and Balance
Avinash Jaiganesh, Yoshie Narui, Raul Raya-Secchi, and Marcos Sotomayor
Keep Your Friends Close: Cell-Cell Contact and Skeletal Myogenesis
Robert S. Krauss, Giselle A. Joseph, and Aviva J. Goel
The Cadherin Superfamily in Neural Circuit Assembly
James D. Jontes
Cell-cell junctions and disease
Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease
Aaron Buckley and Jerrold R. Turner
VE-Cadherin, Adherens Junctions, and Vascular Disease
Maria Grazia Lampugnani, Elisabetta Dejana, and Costanza Giampietro
Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer
Heather C. Bruner and Patrick W.B. Derksen
Connexins and Disease
Mario Delmar, Dale W. Laird, Christian C. Naus, Morten S. Nielsen, Vytas K. Verselis, and Thomas W. White


review:  “ . . . the collection of chapters in this book highlight the remarkable diverse biological functions of intercellular junction proteins while also addressing future research directions in this vast and continuously evolving scientific field. This volume will be of great interest to cell and developmental biologists in addition to others who want to understand how intercellular junction proteins impact development, health and human disease.”
      —The Quarterly Review of Biology