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Signal Transduction: Principles, Pathways, and Processes

Subject Area(s):  Developmental BiologyCell BiologyMolecular BiologyBiochemistry

Edited by Lewis Cantley, Harvard Medical School; Tony Hunter, The Salk Institute; Richard Sever, Cold Spring Harbor Laboratory; Jeremy Thorner, University of California, Berkeley

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© 2014 • 452 pp., illus. (143 color, 5 B&W), index
Paperback • $95 76.00
ISBN  978-1-621821-81-6
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Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately.

This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function.

The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.


Edmond Fischer
1 Signals and Receptors
Carl-Henrik Heldin, Benson Lu, Ron Evans, and J. Silvio Gutkind
2 Protein Regulation in Signal Transduction
Michael J. Lee and Michael B. Yaffe
3 Second Messengers
Alexandra C. Newton, Martin D. Bootman, and John D. Scott
4 Signaling Networks: Information Flow, Computation, and Decision Making
Evren U. Azeloglu and Ravi Iyengar
MAP Kinase Pathways
Deborah K. Morrison
The PI3K-PKB/Akt Pathway
Brian A. Hemmings and David F. Restuccia
mTOR Signaling
Mathieu Laplante and David M. Sabatini
Calcium Signaling
Martin D. Bootman
The Cyclic AMP Pathway
Paolo Sassone-Corsi
Wnt Signaling
Roel Nusse
Hedgehog Signaling
Philip W. Ingham
Notch Signaling
Raphael Kopan
Signaling by the TGFβ Superfamily
Jeffrey L. Wrana
The JAK/STAT Pathway
Douglas A. Harrison
Toll-Like Receptor Signaling
Kian-Huat Lim and Louis M. Staudt
Immunoreceptor Signaling
Lawrence E. Samelson
Signaling by Nuclear Receptors
Richard Sever and Christopher K. Glass
The Hippo Pathway
Kieran F. Harvey and Iswar K. Hariharan
5 Signaling Pathways that Control Cell Proliferation
Robert J. Duronio and Yue Xiong
6 Signaling Pathways that Regulate Cell Division
Nicholas Rhind and Paul Russell
7 Signaling in Control of Cell Growth and Metabolism
Patrick S. Ward and Craig B. Thompson
8 Signaling Networks that Regulate Cell Migration
Peter Devreotes and Alan Rick Horwitz
9 Signaling Pathways in Cell Polarity
Luke Martin McCaffrey and Ian G. Macara
10 Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning
Norbert Perrimon, Chrysoula Pitsouli, and Ben-Zion Shilo
11 Signaling by Sensory Receptors
David Julius and Jeremy Nathans
12 Synaptic Signaling in Learning and Memory
Mary B. Kennedy
13 Signaling in Muscle Contraction
Ivana Y. Kuo and Barbara E. Ehrlich
14 Organismal Carbohydrate and Lipid Homeostasis
D. Grahame Hardie
15 Signaling in Innate Immunity and Inflammation
Kim Newton and Vishva M. Dixit
16 Signaling in Lymphocyte Activation
Doreen Cantrell
17 Vertebrate Reproduction
Sally Kornbluth and Rafael Fissore
18 Cell Signaling and Stress Responses
Gökhan S. Hotamisligil and Roger J. Davis
19 Cell Death Signaling
Douglas R. Green and Fabien Llambi
20 Subversion of Cell Signaling by Pathogens
Neal M. Alto and Kim Orth
21 Signal Transduction in Cancer
Richard Sever and Joan S. Brugge
22 Outlook
Jeremy Thorner, Tony Hunter, Lewis C. Cantley, and Richard Sever


review:  “...a one-stop shop for signaling excels in providing information on just about any aspect of signal transduction imaginable...written by a veritable who’s who of the signaling is a magnum opus and should be a reference source...”
      —Science Signaling

review:  “The comprehensive nature of this superb textbook, as well as its careful and lucid writing, clear illustrations, and extensive references, makes it a must read for graduate students and research personnel.”

review:  “I give this book an excellent review, with regard to its clear explanations and use of diagramming to illustrate cell communication.”
      —Olive Branch United Blog

review:  “...the editors recruited the most distinguished scientists in special areas as coauthors. Through the contributions of about 60 individual authors, a book developed, which covers not only the state of the art of signal transduction, but a volume that can serve as a source of knowledge and stimulating inspiration for interested students and investigators.”
      —The Quarterly Review of Biology