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Stem Cells: From Biological Principles to Regenerative Medicine

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyCell Biology

Edited by Cristina Lo Celso; Kristy Red-Horse; Fiona M. Watt

Download a Free Excerpt from Stem Cells: From Biological Principles to Regenerative Medicine:

Specification of the First Mammalian Cell Lineages In Vivo and In Vitro

© 2020 • 314 pages, illustrated (61 color), index
Hardcover •
ISBN  978-1-621823-39-1

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  •     Description    
  •     Contents    


Stem cells are the progenitors of specialized cell types in the body and have the ability to self-renew. They play critical roles during embryonic development and in the maintenance and repair of adult tissues. Given their plasticity and regenerative abilities, stem cells provide opportunities for treating human diseases such as diabetes.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines recent progress in our understanding of stem cell biology and how the properties of stem cells can be manipulated for therapeutic purposes, emphasizing the roles that cutting-edge technologies and interdisciplinary approaches have played in this work. The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues (e.g., epithelia and brain), and what happens when stem cell integrity is compromised (e.g., by DNA mutations). They also explore specialized niches in which stem cells reside (e.g., in the testis and lung) and how the extracellular cues in those microenvironments regulate stem cell behavior. Many chapters illustrate how single-cell profiling, stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and other modern approaches have offered important insights.

In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. This volume is therefore an indispensable reference for molecular, cell, and developmental biologists, as well as anyone wishing to explore the possibilities of stem cells in regenerative medicine and tissue engineering.


Modeling Brain Disorders Using Induced Pluripotent Stem Cells
Krishna C. Vadodaria, Jeffrey R. Jones, Sara Linker, and Fred H. Gage
Brain Organoids: Human Neurodevelopment in a Dish
Silvia Benito-Kwiecinski and Madeline A. Lancaster
Toward Combined Cell and Gene Therapy for Genodermatoses
Laura De Rosa, Maria Carmela Latella, Alessia Secone Seconetti, Cecilia Cattelani, Johann W. Bauer, Sergio Bondanza, and Michele De Luca
Development of Stem Cell Therapies for Retinal Degeneration
Emma L. West, Joana Ribeiro, and Robin R. Ali
Next-Generation Biomaterials for Culture and Manipulation of Stem Cells
Koichiro Uto, Christopher K. Arakawa, and Cole A. DeForest
A Synthesis Concerning Conservation and Divergence of Cell Types across Epithelia
Daniel T. Montoro, Adam L. Haber, Jennifer E. Rood, Aviv Regev, and Jayaraj Rajagopal
A Stem Cell Approach to Cure Type 1 Diabetes
Aharon Helman and Douglas A. Melton
Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas
Silvia Ruzittu, David Willnow, and Francesca M. Spagnoli
Stem Cell DNA Damage and Genome Mutation in the Context of Aging and Cancer Initiation
Lara Al zouabi and Allison J. Bardin
Niche Cells and Signals that Regulate Lung Alveolar Stem Cells In Vivo
Nicholas H. Juul, Courtney A. Stockman, and Tushar J. Desai
Discovering New Progenitor Cell Populations through Lineage Tracing and In Vivo Imaging
Rudra Nayan Das and Karina Yaniv
Specification of the First Mammalian Cell Lineages In Vivo and In Vitro
Melanie D. White and Nicolas Plachta
Advancing Stem Cell Research through Multimodal Single-Cell Analysis
Iwo Kucinski and Berthold Gottgens
Capturing Stem Cell Behavior Using Intravital and Live Cell Microscopy
Arianna Fumagalli, Lotte Bruens, Colinda L.G.J. Scheele, and Jacco van Rheenen
Mouse Spermatogenesis Reflects the Unity and Diversity of Tissue Stem Cell Niche Systems
Shosei Yoshida
Tracing the Dynamics of Stem Cell Fate
Lemonia Chatzeli and Benjamin D. Simons