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Neuronal Guidance: The Biology of Brain Wiring

Subject Area(s):  Developmental BiologyCell BiologyNeurobiology

Edited by Marc Tessier-Lavigne, The Rockefeller University; Alex L. Kolodkin, Johns Hopkins University School of Medicine

View an excerpt from the book here

© 2011 • 397 pp., illus. (87 color, 6 b/w), index
Trim size: 7" x 10"
Hardcover • $135 54.00
ISBN  978-0-879698-97-3
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During the development of the brain growing nerves send out neuronal processes (axons and dendrites) that connect them to other nerve cells, sensory organs, and muscle tissue. Correct targeting of these is the basis for wiring of the entire nervous system and depends on attractive and repulsive molecular cues that guide the developing neurons to the appropriate destination.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the mechanisms underlying neuronal guidance and branching and their roles in the development and function of the nervous system. The contributors examine the major guidance cues and their receptors, the intracellular signaling pathways they activate, and their function in the context of important phenomena such as laminar organization and dendrite spacing. Other chapters consider the roles of guidance cues in development of neuronal circuits dedicated to the processing of particular sensory stimuli, such as the visual and olfactory systems. In addition, they cover the roles played by guidance cues and their receptors in neuronal regeneration and human genetic disorders, revealing important clinical implications of work in this field.

The book also contains chapters discussing the function of guidance molecules in other processes, such as neuronal cell body migration, axon pruning, and regulation of neuronal cell death. In addition, it explores their roles outside the nervous system for example, in development of the vasculature. This volume is thus of general interest to cell and developmental biologists, as well as all neurobiologists interested in how the nervous system develops and functions.


Mechanisms and Molecules of Neuronal Wiring: A Primer
Alex L. Kolodkin and Marc Tessier-Lavigne
Cellular Strategies of Axonal Pathfinding
Jonathan Raper and Carol Mason
Navigating Intermediate Targets: The Nervous System Midline
Barry J. Dickson and Yimin Zou
Motor Axon Pathfinding
Dario Bonanomi and Samuel L. Pfaff
Molecular and Cellular Mechanisms of Lamina-specific Axon Targeting
Andrew D. Huberman, Thomas R. Clandinin, and Herwig Baier
Self-avoidance and Tiling: Mechanisms of Dendrite and Axon Spacing
Wesley B. Grueber and Alvaro Sagasti
Visual Map Development: Bidirectional Signaling, Bifunctional Guidance Molecules, and Competition
David A. Feldheim and Dennis D.M. O’Leary
Topographic Mapping—The Olfactory System
Takeshi Imai, Hitoshi Sakano, and Leslie B. Vosshall
Wiring the Brain: The Biology of Neuronal Guidance
Alain Chédotal and Linda J. Richards
Human Genetic Disorders of Axon Guidance
Elizabeth C. Engle
Initiating and Growing an Axon
Franck Polleux and William Snider
The Growth Cone Cytoskeleton in Axon Outgrowth and Guidance
Erik W. Dent, Stephanie L. Gupton, and Frank B. Gertler
Rho and Ras GTPases in Axon Growth, Guidance, and Branching
Alan Hall and Giovanna Lalli
Signaling from Axon Guidance Receptors
Greg J. Bashaw and Rüdiger Klein
Trafficking Guidance Receptors
Bettina Winckler and Ira Mellman
Guiding Neuronal Cell Migrations
Oscar Marín, Manuel Valiente, Xuecai Ge, and Li-Huei Tsai
Guidance Molecules in Synapse Formation and Plasticity
Kang Shen and Christopher W. Cowan
Guidance Molecules in Axon Pruning and Cell Death
Pierre Vanderhaeghen and Hwai-Jong Cheng
Guidance Molecules in Axon Regeneration
Roman J. Giger, Edmund R. Hollis II, and Mark H. Tuszynski
Axon Guidance Molecules in Vascular Patterning
Ralf H. Adams and Anne Eichmann


review:  “In summary, Neuronal Guidance: The Biology of Brain Wiring achieves a good balance between basic principles and leading cutting-edge research and will prove to be an excellent introductory text for students and postgraduates who are curious about this branch of developmental biology. The book is also refreshing for old hands: after reading it, I felt full of new ideas.”

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