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Wound Healing: From Bench to Bedside

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Developmental BiologyCell BiologyImmunology and Vaccines

Edited by Xing Dai, University of California, Irvine; Sabine Werner, ETH Zürich; Cheng-Ming Chuong, University of Southern California; Maksim Plikus, University of California, Irvine

Wound Healing: From Bench to Bedside

Download a Free Excerpt from Wound Healing: From Bench to Bedside:

Fibroblast Heterogeneity in Healthy and Wounded Skin

© 2023 • 492 pages, illustrated (79 color), index
Hardcover •
ISBN  978-1-621824-44-2

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  •     Description    
  •     Contents    


Efficient wound healing is critical for survival and fitness of all animals. Complex signaling networks within tissues respond to injury by activating repair mechanisms that promote diverse cellular behaviors, including proliferation, migration, and new lineage choices. A better understanding of normal injury responses is essential for the development of therapies for various skin-healing disorders, including chronic wounds, and for strategies aimed at the regeneration of a fully functional skin.

Written and edited by experts in the field, this book reviews our current understanding of the cellular, molecular, and biophysical mechanisms involved in skin wound healing, as well as the function and regulation of different skin cell types, including epithelial cells, fibroblasts, immune cells, neural cells, and endothelial cells. The book includes chapters examining the regulation of wound healing by growth factors, bioelectric signals, biomechanical signals, noncoding RNAs, and the microbiome. Also covered are chronic issues associated with wound healing and potential novel therapeutic approaches to address them. The volume is therefore an essential resource not only for cell and developmental biologists, but also for clinicians interested in understanding translational approaches to development of new therapies for skin wounds.


Wound Healing Insights from Flies and Fish
Anne George and Paul Martin
Wound Healing from an Actin Cytoskeletal Perspective
Parinaz Ahangar, Xanthe L. Strudwick, and Allison J. Cowin
Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing
Min Zhao, Marco Rolandi, and R. Rivkah Isseroff
Beyond the Code: Noncoding RNAs in Skin Wound Healing
Dongqing Li, Guanglin Niu, and Ning Xu Landén
Cellular Senescence in Acute and Chronic Wound Repair
Holly N. Wilkinson and Matthew J. Hardman
Plasticity of Epithelial Cells during Skin Wound Healing
Xiaoyan Sun, Simon Joost, and Maria Kasper
Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing
Remy Vu, Morgan Dragan, Peng Sun, Sabine Werner, and Xing Dai
Fibroblast Heterogeneity in Healthy and Wounded Skin
Clarisse Ganier, Emanuel Rognoni, Georgina Goss, Magnus Lynch, and Fiona M. Watt
Diversity of Fibroblasts and Their Roles in Wound Healing
Dongsheng Jiang, Ruiji Guo, Hans-Günther Machens, and Yuval Rinkevich
The Role of Myofibroblasts in Physiological and Pathological Tissue Repair
Ronen Schuster, Fereshteh Younesi, Maya Ezzo, and Boris Hinz
Role of Macrophages in Wound Healing
Sebastian Willenborg, Louise Injarabian, and Sabine A. Eming
Angiogenesis in Wound Repair: Too Much of a Good Thing?
Chen Han, May Barakat, and Luisa A. DiPietro
The Wound Microbiome
Ellen K. White and Elizabeth A. Grice
Wound-Induced Hair Neogenesis: A Portal to the Development of New Therapies for Hair Loss and Wound Regeneration
Allen S.W. Oak and George Cotsarelis
Toward Understanding Wound Immunology for High-Fidelity Skin Regeneration
Yingchao Xue, Sashank K. Reddy, and Luis A. Garza
Bioinspired Strategies for Wound Regeneration
Hans I-Chen Harn, Jeffrey M. Davidson, and Cheng-Ming Chuong
The Contribution of Innervation to Tissue Repair and Regeneration
Adam P.W. Johnston and Freda D. Miller
Intrinsic Networks Regulating Tissue Repair: Comparative Studies of Oral and Skin Wound Healing
Andrew M. Overmiller, Andrew P. Sawaya, Emma D. Hope, and Maria I. Morasso
Molecular Pathophysiology of Chronic Wounds: Current State and Future Directions
Irena Pastar, Nathan C. Balukoff, Jelena Marjanovic, Vivien Y. Chen, Rivka C. Stone, and Marjana Tomic-Canic
Keloid Disorder: Genetic Basis, Gene Expression Profiles, and Immunological Modulation of the Fibrotic Processes in the Skin
Alexa J. Cohen, Neda Nikbakht, and Jouni Uitto
Mesenchymal Stem Cell–Derived Extracellular Vesicles as an Advanced Therapy for Chronic Wounds
Eric R. Bray, Robert S. Kirsner, and Evangelos V. Badiavas
Growth Factor and Cytokine Delivery Systems for Wound Healing
Julien M.D. Legrand and Mikaël M. Martino
Engineering Immunomodulatory Biomaterials to Drive Skin Wounds toward Regenerative Healing
Sergei Butenko, Hiromi Miwa, Yingzi Liu, Maksim V. Plikus, Phillip O. Scumpia, and Wendy F. Liu
Stairways to Advanced Therapies for Epidermolysis Bullosa
Laura De Rosa, Elena Enzo, Michele Palamenghi, Laura Sercia, and Michele De Luca