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Influenza: The Cutting Edge

Book Series:  A Cold Spring Harbor Perspectives in Medicine Collection
Subject Area(s):  Human Biology and DiseaseImmunology and VaccinesViruses

Edited by Gabriele Neumann, University of Wisconsin – Madison; Yoshihiro Kawaoka, University of Wisconsin – Madison

Download a Free Excerpt from Influenza: The Cutting Edge:

The Ecology and Evolution of Influenza Viruses

© 2021 • 749 pages, illustrated (111 color and 4 B&W), index
Hardcover •
ISBN  978-1-621823-07-0

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  •     Description    
  •     Contents    
  •     Reviews    


Influenza is a serious infectious disease caused by different influenza viruses that can mutate to form new strains. Some of these strains give rise to epidemics or pandemics, infecting millions worldwide each year. Because evolutionary changes in these viruses are difficult to predict and our understanding of their pathogenic effects is incomplete, the development of effective vaccines and therapeutics for influenza remains challenging.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews cutting-edge research on the viruses that cause influenza, the molecular mechanisms of infection, the epidemiology of these viruses in humans and animals, and current strategies for designing vaccines and antivirals. Contributors discuss all aspects of the molecular virology of influenza—the viral and host factors involved in the attachment and entry into host cells, the transcription and replication of viral genomes, and virus assembly and budding. The various factors and conditions that determine susceptibility to influenza infection and disease severity are also covered, as is our current understanding of the ecology and evolution of influenza viruses, the various subtypes, and their transmission and epidemiology in humans, birds, swine, bats, and other animals.

In addition, the authors examine the human immune response to influenza infection, insights gained from animal models, and technological advances in the design and delivery of vaccines and antivirals. This volume is therefore an essential reference for all virologists, clinical and laboratory investigators, and physicians interested in reducing the global public health burden of influenza.


Structure and Function of the Influenza Virus Transcription and Replication Machinery
Ervin Fodor and Aartjan J.W. te Velthuis
Structure and Function of Influenza Polymerase
Joanna M. Wandzik, Tomas Kouba, and Stephen Cusack
Hemagglutinin Structure and Activities
Steven J. Gamblin, Sébastien G. Vachieri, Xiaoli Xiong, Jie Zhang, Stephen R. Martin, and John J. Skehel
Influenza Hemagglutinin Structures and Antibody Recognition
Nicholas C. Wu and Ian A. Wilson
The Structure, Function, and Pathobiology of the Influenza A and B Virus Ion Channels
Robert A. Lamb
Accessory Gene Products of Influenza AVirus
Rute M. Pinto, Samantha Lycett, Eleanor Gaunt, and Paul Digard
Selective Genome Packaging Mechanism of Influenza A Viruses
Takeshi Noda
Host Cell Factors That Interact with Influenza Virus Ribonucleoproteins
Ecco Staller and Wendy S. Barclay
The Two Sides of the Same Coin—Influenza Virus and Intracellular Signal Transduction
Stephan Ludwig, Eike R. Hrincius, and Yvonne Boergeling
Experimental Approaches to Identify Host Factors Important for Influenza Virus
Grace A. Schaack and Andrew Mehle
Synthetic Virology: Building Viruses to Better Understand Them
Benjamin R. tenOever
Quantifying Between-Host Transmission in Influenza Virus Infections
Katherine E.E. Johnson and Elodie Ghedin
The Ecology and Evolution of Influenza Viruses
Michelle Wille and Edward C. Holmes
Influenza Reverse Genetics—Historical Perspective
Gabriele Neumann
The 1918 Influenza Pandemic and Its Legacy
Jeffery K. Taubenberger and David M. Morens
Human Susceptibility to Influenza Infection and Severe Disease
Robert C. Mettelman and Paul G. Thomas
Influenza in Children
Jennifer Nayak, Gregory Hoy, and Aubree Gordon
Influenza in High-Risk Hosts—Lessons Learned from Animal Models
Rebekah Honce, Nicholas Wohlgemuth, Victoria A. Meliopoulos, Kirsty R. Short, and Stacey Schultz-Cherry
Human Influenza Epidemiology
Sukhyun Ryu and Benjamin J. Cowling
The Epidemiology, Virology, and Pathogenicity of Human Infections with Avian Influenza Viruses
Dayan Wang, Wenfei Zhu, Lei Yang, and Yuelong Shu
Emerging HxNy Influenza AViruses
William J. Liu, Yan Wu, Yuhai Bi, Weifeng Shi, Dayan Wang, Yi Shi, and George F. Gao
H5 Influenza Viruses in Egypt
Rabeh El-Shesheny, Ahmed Kandeil, Ahmed Mostafa, Mohamed A. Ali, and Richard J. Webby
H7N9 Influenza Virus in China
Chengjun Li and Hualan Chen
H9 Influenza Viruses: An Emerging Challenge
Silvia Carnaccini and Daniel R. Perez
Pathobiological Origins and Evolutionary History of Highly Pathogenic Avian Influenza Viruses
Dong-Hun Lee, Miria Ferreira Criado, and David E. Swayne
Swine Influenza AViruses and the Tangled Relationship with Humans
Tavis K. Anderson, Jennifer Chang, Zebulun W. Arendsee, Divya Venkatesh, Carine K. Souza, J. Brian Kimble, Nicola S. Lewis, C. Todd Davis, and Amy L. Vincent
Equine Influenza
Thomas M. Chambers
Canine and Feline Influenza
Brian R. Wasik, Ian E.H. Voorhees, and Colin R. Parrish
Bat-Borne Influenza AViruses: An Awakening
Kevin Ciminski and Martin Schwemmle
Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model
Jessica A. Belser, Joanna A. Pulit-Penaloza, and Taronna R. Maines
Original Antigenic Sin: How Original? How Sinful?
Jonathan W. Yewdell and Jefferson J.S. Santos
Influenza Vaccines Delivered in Early Childhood Could Turn Antigenic Sin into Antigenic Blessings
Michael Worobey, Stanley Plotkin, and Scott E. Hensley
Immunity to Influenza Infection in Humans
David J. Topham, Marta L. DeDiego, Aitor Nogales, Mark Y. Sangster, and Andrea Sant
Influenza Immunization in the Context of Preexisting Immunity
Susanne L. Linderman, Ali H. Ellebedy, Carl Davis, Christiane S. Eberhardt, Rustom Antia, Rafi Ahmed, and Veronika I. Zarnitsyna
Induction and Evasion of Type-I Interferon Responses during Influenza A Virus Infection
Raquel Muñoz-Moreno, Carles Martínez-Romero, and Adolfo García-Sastre
Systems Biological Analysis of Immune Response to Influenza Vaccination
Mario Cortese, Amy C. Sherman, Nadine G. Rouphael, and Bali Pulendran
Next-Generation Influenza Vaccines
Masaru Kanekiyo and Barney S. Graham
Influenza Vaccine Effectiveness: New Insights and Challenges
Huong Q. McLean and Edward A. Belongia
Live Attenuated Cold-Adapted Influenza Vaccines
Kanta Subbarao
Influenza Therapeutics in Clinical Practice—Challenges and Recent Advances
John H. Beigel and Frederick G. Hayden
Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance
Emi Takashita
Antivirals Targeting the Neuraminidase
Larisa Gubareva and Teena Mohan


review:  “The figures and tables are clear, and the encycl0pedic content covered represents hot-off-the-press primary research. The authors present complex topics with clarity, depth, and appropriate nuance. Therefore, this volume is an all-encompassing A to Z of all things influenza virus: from its historical origins and evolution, molecular virology, host-range, and pathogenesis to providing perspectives on the legacy of past pandemics and implications for future pandemic preparedness, and innovative vaccine design. This is an essential book for any graduate student working on influenza virus or indeed for faculty or educators who wish to assimilate knowledge on the latest developments in influenza virus research.”
      —The Quarterly Review of BIology