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Innate Immunity & Inflammation

Book Series:  A Cold Spring Harbor Perspectives in Biology Collection
Subject Area(s):  Immunology and Vaccines

Edited by Ruslan Medzhitov, Yale University School of Medicine

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Preface and Contents
Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors

© 2015 • 232 pages, illustrated (41 color), index
Hardcover •
ISBN  978-1-621820-29-1

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  •     Description    
  •     Contents    


The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobilizes the adaptive immune system. Excessive or chronic inflammation may cause tissue damage, so a careful balance is required to restore homeostasis.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the cellular and molecular mechanisms involved in innate immunity and all types of inflammation. The contributors examine the cell types that make up the innate immune system, their use of pattern recognition receptors (e.g., Toll-like receptors) to identify pathogens and damaged tissues, and how they trigger signaling pathways that culminate in inflammation, pathogen destruction, and tissue repair. The numerous chemical signals and factors involved in innate immunity and inflammation are described, as are those that keep inflammation in check.

The authors also discuss the diseases that can result when these processes go awry, such as rheumatoid arthritis and cancer. This volume is therefore a valuable reference for all immunologists, cell biologists, and medical scientists wishing to understand these protective processes and their implications for human health and disease.


Microbial Sensing by Toll-Like Receptors and Intracellular Nucleic Acid Sensors
Surya Pandey, Taro Kawai, and Shizuo Akira
Emerging Principles Governing Signal Transduction by Pattern-Recognition Receptors
Jonathan C. Kagan and Gregory M. Barton
Transcriptional Control of Inflammatory Responses
Stephen T. Smale and Gioacchino Natoli
Marcel R. de Zoete, Noah W. Palm, Shu Zhu, and Richard A. Flavell
Tumor Necrosis Family Superfamily in Innate Immunity and Inflammation
John Šedý, Vasileios Bekiaris, and Carl F. Ware
IL-6 in Inflammation, Immunity, and Disease
Toshio Tanaka, Masashi Narazaki, and Tadamitsu Kishimoto
The Chemokine System in Innate Immunity
Caroline L. Sokol and Andrew D. Luster
Lipid Mediators in the Resolution of Inflammation
Charles N. Serhan, Nan Chiang, Jesmond Dalli, and Bruce D. Levy
DNA Degradation and Its Defects
Kohki Kawane, Kou Motani, and Shigekazu Nagata
Group 2 Innate Lymphoid Cells in Health and Disease
Brian S. Kim and David Artis
Allergic Inflammation—Innately Homeostatic
Laurence E. Cheng and Richard M. Locksley
Inflammation and the Blood Microvascular System
Jordan S. Pober and William C. Sessa
Sinusoidal Immunity: Macrophages at the Lymphohematopoietic Interface
Siamon Gordon, Annette Plüddemann, and Subhankar Mukhopadhyay
Approaching the Next Revolution? Evolutionary Integration of Neural and Immune Pathogen Sensing and Response
Kevin J. Tracey