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Hepatitis C Virus: The Story of a Scientific and Therapeutic Revolution

Subject Area(s):  Infectious DiseasesHuman Biology and DiseaseDiseasesViruses

Edited by Arash Grakoui, Emory University; Jean-Michel Pawlotsky, Hopital Henri Mondor / Universite Paris Est; Glenn Randall, University of Chicago

Download a Free Excerpt from Hepatitis C Virus: The Story of a Scientific and Therapeutic Revolution:

Hepatitis C Virus: 30 Years after Its Discovery

© 2020 • 298 pages, illustrated (37 color and 2 B&W), index
Hardcover •
ISBN  978-1-621823-19-3

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  •     Description    
  •     Contents    


Hepatitis C is a liver disease caused by infection with the hepatitis C virus (HCV), a bloodborne pathogen. In some people, an immune response will clear the infection; however, in most, the infection becomes chronic and treatment with antiviral medication is necessary to prevent serious liver damage and cancer. The eradication of HCV will require improved access to diagnosis and treatment, an enhanced understanding of virus–host interactions, and the development of an effective vaccine.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines all aspects of the biology of HCV, the pathological consequences of infection, the current standard of hepatitis C treatment, and ongoing efforts to control the disease. Contributors discuss the structural and biochemical properties of HCV, the molecular details of its life cycle, and how it promotes liver disease by perturbing host cell signaling pathways. They likewise examine the innate and adaptive immune responses elicited by HCV and why those responses often fail to clear the infection. Direct-acting antiviral regimens to treat infected patients, the impacts of those treatments on hepatitis C epidemiology, and obstacles to HCV elimination (e.g., vaccine development) are also covered.

This volume includes additional perspectives on the discovery of HCV, historical milestones in HCV research, and animal and cell culture models of HCV infection. It is an essential reference for virologists, immunologists, and all clinical and laboratory investigators interested in eliminating HCV as a public health threat.


Hepatitis C Virus: 30 Years after Its Discovery
Michael Houghton
Hepatitis C Virus Structure: Defined by What It Is Not
Altaira D. Dearborn and Joseph Marcotrigiano
Cell Culture Systems of HCV Using JFH-1 and Other Strains
Takaji Wakita
Animal Models of Hepatitis C Virus Infection
Alexander Ploss and Amit Kapoor
Hepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion
Gisa Gerold, Rebecca Moeller, and Thomas Pietschmann
Hepatitis C Virus Replication
Keisuke Tabata, Christopher J. Neufeldt, and Ralf Bartenschlager
HCVAssembly and Egress via Modifications in Host Lipid Metabolic Systems
Kunitada Shimotohno
Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis
Alessia Virzì, Armando Andres Roca Suarez, Thomas F. Baumert, and Joachim Lupberger
Innate Immunity in Hepatitis C Virus Infection
Johannes Schwerk, Amina Negash, Ram Savan, and Michael Gale, Jr.
Control of HCV Infection by Natural Killer Cells and Macrophages
Hugo R. Rosen and Lucy Golden-Mason
T-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy
Stephanie Smith, Jonathan R. Honegger, and Christopher Walker
Antibody Responses in Hepatitis C Infection
Mansun Law
Interferon-Free Hepatitis C Virus Therapy
Jean-Michel Pawlotsky
Hepatitis C Virus Epidemiology and the Impact of Interferon-Free Hepatitis C Virus Therapy
Jeffrey V. Lazarus, Elena Roel, and Ahmed M. Elsharkawy
Natural History of Hepatic and Extrahepatic Hepatitis C Virus Diseases and Impact of Interferon-Free HCV Therapy
Francesco Negro
The Elimination of Hepatitis C as a Public Health Threat
Margaret Hellard, Sophia E. Schroeder, Alisa Pedrana, Joseph Doyle, and Campbell Aitken
Challenges and Promise of a Hepatitis C Virus Vaccine
Andrea L. Cox