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Immune Tolerance

Subject Area(s):  Human Biology and DiseaseImmunology and Vaccines

Edited by Diane J. Mathis, Harvard Medical School; Alexander Y. Rudensky, Howard Hughes Medical Institute and Memorial Sloan-Kettering Cancer Center

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© 2013 • 168 pp., illus. (2 B&W, 20 4C), index
Hardcover •
ISBN  978-0-879698-95-9

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Immune tolerance ensures that the immune system responds to foreign molecules and not to self-molecules. When tolerance breaks down, severe, self-destructive diseases such as rheumatoid arthritis, lupus, and multiple sclerosis may develop. Understanding the mechanisms involved in establishing and maintaining immune tolerance is essential for effectively treating these autoimmune diseases.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews how self-tolerant T- and B-cell populations are produced. The contributors discuss the elimination of autoreactive lymphocytes during their development in the thymus and bone marrow, the suppression of autoreactive cells by regulatory T cells in the periphery, and intrinsic mechanisms that produce clonal anergy. The roles of dendritic cells in antigen presentation and mechanisms that prevent autoreactivity in natural killer cells are also covered.

Including discussions of autoimmune diseases, their genetic bases, and therapeutic strategies, this book is a valuable reference for all immunologists and clinicians wishing to understand or develop treatments for autoimmune diseases.


Historical Overview of Immunological Tolerance
Ronald H. Schwartz
T-Cell Tolerance: Central and Peripheral
Yan Xing and Kristin A. Hogquist
Treg Cells, Life History, and Diversity
Christophe Benoist and Diane Mathis
Dendritic Cells: Arbiters of Immunity and Immunological Tolerance
Kanako L. Lewis and Boris Reizis
Central B-Cell Tolerance: Where Selection Begins
Roberta Pelanda and Raul M. Torres
Natural Killer Cell Tolerance: Control by Self or Self-Control?
Baptiste N. Jaeger and Eric Vivier
The Immunogenetic Architecture of Autoimmune Disease
An Goris and Adrian Liston
Microbiota and Autoimmunity
Alexander V. Chervonsky
Infectious (Non)tolerance—Frustrated Commensalism Gone Awry?
Jesse C. Nussbaum and Richard M. Locksley
Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases
Jeffrey A. Bluestone and Hélène Bour-Jordan

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