Retinal Disorders: Genetic Approaches to Diagnosis and Treatment, Second Edition

Click to Enlarge				Retinal Disorders: Genetic Approaches to Diagnosis and Treatment, Second Edition Subject Area(s): Gene Therapy; Genetics; Neurobiology Edited by Eyan Banin, Hadassah-Hebrew University Medical Center, Jerusalem; Jean Bennett, University of Pennsylvania Perelman School of Medicine; Jacque L. Duncan, University of California, San Francisco; Botond Roska, IOB, Basel, Switzerland; José-Alain Sahel, University of Pittsburgh School of Medicine

				Due January 2024 • 400 pages (approx.), illustrated, index Hardcover • ~~$79~~ 55.30 ISBN 978-1-621824-62-6 You save: 30% You will receive free shipping on this item at checkout. Free shipping offer applies to direct website purchases by individual U.S. and Canada customers only.

Description Contents Description The retina is a layer of neural tissue that lines the inner eye and captures visual stimuli. This volume provides an update on retinal diseases, describing the genetic and pathophysiological basis of the diseases and advances in strategies to treat them. Contents Preliminary Introduction Genetics and pathophysiology of inherited retinal degenerations An historical perspective on gene discovery in retinal dystrophies Stephen P. Daiger Gene poll studies Kari Branham World-wide carrier rates for IRD genes Dror Sharon and Mor Hanany Syndromic ciliopathy-related retinal dystrophies models Héène Dollfus High throughput organoid models Magdalena Renner Gene therapies Overview (current status and future challenges) Jean Bennett Lessons learned from the RPE65 story Albert Maguire and Jean Bennett Bringing an innovative therapy to market Kathy High + 1 Choroideremia Robert MacLaren and Imran Yusuf RPGR Michel Michaelides, Michalis Georgiou, Saima Hasahem, and Robin Ali Achromatopsia Eyal Banin From Bench to Bedside—Delivering Gene Therapy for Leber Hereditary Optic Neuropathy Benson S. Chen and Patrick Yu-Wai-Man Retinoschisis Paul Sieving Gene Therapy for Rhodopsin Mutations Alfred S. Lewin and W. Clay Smith Gene-independent approaches: Neuroprotection Thierry Léveillard, Géraldine Puel, and Najate Ait-Ali Glucose metabolism Constance Cepko and Yunlun Xue Optogenetics 1 Botond Roska and José-Alain Sahel Optogenetics 2 John Flannery and Antonia Stefanov Developing new vectors Deniz Dalkara and Leah Byrne Immune responses Kathryn Pepple and Debarshi Mustafi Therapeutic Gene Editing in Inherited Retinal Disorders Jinjie Ling, Laura A. Jenny, Ashley Zhou, and Stephen H. Tsang New medical therapies (related to use of retinal organoids) Don Zack Visual Prosthesis Electronic Retinal Prostheses Daniel Palanker Cell-based therapies Overview Pete Coffey iPSc Cell therapy 1 Masayo Takahashi iPSc Cell therapy 2 Khapil Bharti and Fnu Ruchi Retinal dystrophies (will focus on photoreceptor cell therapy) Christelle Monville, Olivier Goureau, and Karim Ben M’Barek Strategies for regeneration Tom Reh Preparing Clinical trials, and outcome measures Rodent models Serge Picaud & Valérie Fradot Pathomechanisms and perspectives for neuroprotection Francois Paquet-Durand Large animal models: Dogs, cats, sheep, and cattle achromatopsia models Simon Petersen-Jones and Andras Komaromy Pig models Maureen McCall High resolution imaging Joe Carroll and Niamh Wynne The importance of natural history studies Allison Ayala Patient-reported outcomes Todd Durham Performance-based tests Daniel Chung Performance-based tests Colas Authié Current status of clinical trials design and outcomes Jacque Duncan and Eyal Banin Index

Retinal Disorders: Genetic Approaches to Diagnosis and Treatment, Second Edition

Description

Contents